scholarly journals Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin

2009 ◽  
Vol 174 (1) ◽  
pp. 101-114 ◽  
Author(s):  
Gary J. Fisher ◽  
Taihao Quan ◽  
Trupta Purohit ◽  
Yuan Shao ◽  
Moon Kyun Cho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Matrix Metalloproteinase ◽  
Human Skin ◽  
Matrix Metalloproteinase 1

Tight Control of Matrix Metalloproteinase-1 Activity in Human Skin¶

2003 ◽  
Vol 78 (4) ◽  
pp. 355 ◽  
Author(s):  
Kirstin M. Südel ◽  
Kirsten Venzke ◽  
Elke Knußmann-Hartig ◽  
Ingrid Moll ◽  
Franz Stäb ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Human Skin ◽  
Tight Control ◽  
Matrix Metalloproteinase 1

scholarly journals Human skin gene expression: Natural (trans) resveratrol versus five resveratrol analogs for dermal applications

2017 ◽  
Vol 242 (15) ◽  
pp. 1482-1489 ◽  
Author(s):  
Edwin D Lephart ◽  
Merritt B Andrus
Keyword(s):  
Gene Expression ◽  
Biological Activity ◽  
Matrix Metalloproteinase ◽  
Human Skin ◽  
Biological Activities ◽  
Gene Array ◽  
Biologically Active ◽  
Nuclear Antigen ◽  
Matrix Metalloproteinase 1 ◽  
Resveratrol Analogs

Resveratrol (RV) is a polyphenolic compound naturally produced by plants. Polyphenolic compounds incorporated into medicinal products are beneficial but, RV is rapidly metabolized with an associated decline in biological activity. This study tested RV as the standard and compared five structurally modified RV analogs: butyrate, isobutyrate, palmitoate, acetate, and diacetate (to improve functionality) at 1% concentration(s) for 24 h in epiderm full thickness cultures by gene array/qPCR mRNA analysis. When silent mating type information regulation 2 homolog 1, extracellular elements (collagen1A1, 3A1, 4A1; elastin, tissue inhibitor of matrix metalloproteinase 1, fibrillin 1 laminin beta1 and matrix metalloproteinase 9), anti-aging and aging genes, inflammatory biomarkers (interleukin-1A [IL1A], IL1R2, IL-6 and IL-8), nerve growth factor, and the antioxidants (proliferating cell nuclear antigen, catalase, superoxide dismutase and metallothionein 1H/2H) were evaluated, ranking each from highest-to-lowest for gene expression: butyrate > isobutyrate > diacetate > acetate > palmitoate. This study showed that the butyrate and isobutyrate analogs are more biologically active compared to resveratrol and have potential use in topical applications to improve dermal and other health applications. Impact statement Resveratrol has been reported to have a wide variety of health benefits but its rapid metabolism especially after oral ingestion results in very low bioavailability. Notably, the first human skin gene expression study of resveratrol was not published until 2014. The purpose of this study was to determine if increased stability and biological activity could be obtained by modifying the chemical structure of natural (trans) resveratrol and quantifying human gene expression by qPCR of skin biomarkers that enhance dermal health. Five resveratrol analogs were synthesized that increased their lipophilic index to enhance tissue penetration and augment biological activities on the measured parameters that expand the current knowledge of structure/function relationships. The butyrate and isobutyrate modifications displayed gene expression values significantly above resveratrol and suggest that oral application of these and potentially other resveratrol analogs may yield similar results to improve stability and biological activity to benefit/address various disorders/diseases.

The effect of curculigoside on the expression of matrix metalloproteinase-1 in cultured human skin fibroblasts

2009 ◽  
Vol 32 (10) ◽  
pp. 1433-1439 ◽  
Author(s):  
Song-Yi Lee ◽  
Mi-Ran Kim ◽  
Hong Seok Choi ◽  
Hyung-In Moon ◽  
Jin Ho Chung ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Matrix Metalloproteinase 1
Sign in / Sign up

Export Citation Format

Share Document