Inhibition of Matrix Metalloproteinase-1 Induced by Oxidative Stress in Human Keratinocytes by Mangiferin Isolated fromAnemarrhena asphodeloides

2011 ◽  
Vol 75 (12) ◽  
pp. 2321-2325 ◽  
Author(s):  
Sungwook CHAE ◽  
Mei Jing PIAO ◽  
Kyoung Ah KANG ◽  
Rui ZHANG ◽  
Ki Cheon KIM ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Matrix Metalloproteinase ◽  
Human Keratinocytes ◽  
Matrix Metalloproteinase 1

scholarly journals Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin

2009 ◽  
Vol 174 (1) ◽  
pp. 101-114 ◽  
Author(s):  
Gary J. Fisher ◽  
Taihao Quan ◽  
Trupta Purohit ◽  
Yuan Shao ◽  
Moon Kyun Cho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Matrix Metalloproteinase ◽  
Human Skin ◽  
Matrix Metalloproteinase 1

scholarly journals Tectorigenin, a Flavonoid-Based Compound of Leopard Lily Rhizome, Attenuates UV-B-Induced Apoptosis and Collagen Degradation by Inhibiting Oxidative Stress in Human Keratinocytes

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1998 ◽  
Author(s):  
Dongjin Noh ◽  
Jin Choi ◽  
Eugene Huh ◽  
Myung Oh
Keyword(s):  
Oxidative Stress ◽  
Uv Light ◽  
Human Keratinocytes ◽  
Collagen Degradation ◽  
Oxidative Enzymes ◽  
Skin Damage ◽  
Protein Levels ◽  
Matrix Metalloproteinase 1 ◽  
Skin Photoaging ◽  
Induced Apoptosis

Ultraviolet (UV) light, a major risk factor for external skin photoaging, induces oxidative stress in skin. UV causes a breakdown of skin homeostasis by impairing the extracellular matrix and inducing cell death. Tectorigenin, a constituent of leopard lily (Belamcanda chinensis L.) rhizome, has been reported to possess antioxidant, hair-darkening, and anti-inflammatory activities; however, the effect of tectorigenin on UV-B-induced skin damage is unknown. Here, we investigated the anti-skin-damage effects of tectorigenin against UV-B-stimulated oxidative stress in human keratinocytes. We irradiated HaCaT cells with UV-B (25 mJ/cm2), followed by treatment with tectorigenin for 24 h. We found that tectorigenin decreased the levels of intracellular reactive oxygen species by increasing the expression of anti-oxidative enzymes, such as glutathione and catalase. Furthermore, tectorigenin inhibited apoptosis by reducing caspase-3- and Bcl-2-associated protein-X levels, and increasing Bcl-2 protein levels. Tectorigenin also decreased matrix metalloproteinase-1 levels and increased type 1 collagen levels, thus preventing collagen degradation. These data demonstrate that tectorigenin exerts anti-skin-damage effects in human keratinocytes by attenuating UV-B-induced hyper-oxidation, apoptosis, and collagen degradation.

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