scholarly journals Preferential Attachment of Peritoneal Tumor Metastases to Omental Immune Aggregates and Possible Role of a Unique Vascular Microenvironment in Metastatic Survival and Growth

2006 ◽  
Vol 169 (5) ◽  
pp. 1739-1752 ◽  
Author(s):  
Scott A. Gerber ◽  
Viktoriya Y. Rybalko ◽  
Chad E. Bigelow ◽  
Amit A. Lugade ◽  
Thomas H. Foster ◽  
...  
Keyword(s):  
Preferential Attachment ◽  
Peritoneal Tumor ◽  
Tumor Metastases ◽  
Survival And Growth ◽  
Immune Aggregates

scholarly journals YaeB, Expressed in Response to the Acidic pH in Macrophages, Promotes Intracellular Replication and Virulence of Salmonella Typhimurium

2019 ◽  
Vol 20 (18) ◽  
pp. 4339 ◽  
Author(s):  
Huan Zhang ◽  
Xiaorui Song ◽  
Peisheng Wang ◽  
Runxia Lv ◽  
Shuangshuang Ma ◽  
...  
Keyword(s):  
Salmonella Enterica Serovar Typhimurium ◽  
Intracellular Pathogen ◽  
Acidic Ph ◽  
Intracellular Replication ◽  
Global Regulator ◽  
Serovar Typhimurium ◽  
Survival And Growth ◽  
Bacterial Replication ◽  
Specific Transport System

Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that infects humans and animals. Survival and growth in host macrophages represents a crucial step for S. Typhimurium virulence. Many genes that are essential for S. Typhimurium proliferation in macrophages and associated with virulence are highly expressed during the intracellular lifecycle. yaeB, which encodes an RNA methyltransferase, is also upregulated during S. Typhimurium growth in macrophages. However, the involvement of YaeB in S. Typhimurium pathogenicity is still unclear. In this study, we investigated the role of YaeB in S. Typhimurium virulence. Deletion of yaeB significantly impaired S. Typhimurium growth in macrophages and virulence in mice. The effect of yaeB on pathogenicity was related to its activation of pstSCAB, a phosphate (Pi)-specific transport system that is verified here to be important for bacterial replication and virulence. Moreover, qRT-PCR data showed YaeB was induced by the acidic pH inside macrophages, and the acidic pH passed to YeaB through inhibiting global regulator histone-like nucleoid structuring (H-NS) which confirmed in this study can repress the expression of yaeB. Overall, these findings identified a new virulence regulatory network involving yaeB and provided valuable insights to the mechanisms through which acidic pH and low Pi regulate virulence.

scholarly journals The Role of Management by Exception in Achieving Entrepreneurial Leadership

2017 ◽  
Vol 1 (8) ◽  
Author(s):  
  Elderdery Ahmed Ismail Medany
Keyword(s):  
Competitive Advantage ◽  
Entrepreneurial Leadership ◽  
Business Organizations ◽  
Leadership And Management ◽  
Survival And Growth ◽  
And Performance

  The aim of this study is to highlight the role that management by exception plays in achieving pioneering leadership and the survival and growth of institutions and trying to increase their effectiveness and performance in light of the great challenges they face. The importance of management is characterized by adding value to the institution, creating a competitive advantage, making the institution more flexible, and adopting the forms of coordination, designing and structuring. The problem of the study is represented in this question: is the application of the concept of management by exception leads to entrepreneurial leadership in business organizations? The study   showed that the entrepreneurial leadership has the ability to influence workers and the performance of institutions. Based on the principles and the basis of modern leadership and management, it is possible for organizations to achieve proactive entrepreneurship among other organizations. by applying entrepreneurial leadership and sorting out the appropriate decisions  

scholarly journals High doses of immunoglobulin G attenuate immune aggregate-mediated complement activation by enhancing physiologic cleavage of C3b in C3bn- IgG complexes

Blood ◽  
1996 ◽  
Vol 88 (1) ◽  
pp. 184-193 ◽  
Author(s):  
HU Lutz ◽  
P Stammler ◽  
E Jelezarova ◽  
M Nater ◽  
PJ Spath
Keyword(s):  
Inflammatory Diseases ◽  
Factor H ◽  
Human Igg ◽  
Partial Protection ◽  
Beneficial Effects ◽  
High Concentrations ◽  
High Doses ◽  
Immune Aggregates

Abstract Intravenously applied human IgG has beneficial effects in treating inflammatory diseases, presumably because it has a complement attenuating role. This role of IgG was studied in vitro by following C3 activation and inactivation in sera that were supplemented with exogenous human IgG and incubated with immune aggregates. IgG added at 2 to 10 mg/mL stimulated the physiologic inactivation of C3b-containing complexes twofold to threefold in 20% sera. This, in turn, lowered the overall C3 activation by 28%, as new C3 convertases primarily assembled on C3b-containing complexes. Exogenous IgG (5 mg/mL) also stimulated inactivation of purified C3b2-IgG complexes, whereby their half-life dropped from 3–4 to 1.5 minutes in 20% serum. IgG appeared to act like a modulator of factor H and I because it did not stimulate inactivation of C3b-containing complexes in factor I-deficient serum. Thus, the known partial protection of C3bn-IgG complexes from inactivation by factor H and I was downregulated by high concentrations of IgG. The ability of high doses of IgG to stimulate complement inactivation is a novel regulatory role of IgG. This may be one of the molecular principles for its therapeutic efficacy in treating complement-mediated inflammations.

Abstract C57: The role of stromal cells in tumor metastases

2009 ◽  
Author(s):  
Annique Duyverman ◽  
Dan G. Duda ◽  
Ernst J.A. Steller ◽  
Dai Fukumura ◽  
Rakesh K. Jain
Keyword(s):  
Stromal Cells ◽  
Tumor Metastases

ARMING ASIAN INTELLECTUALS INTERNATIONAL CONSULTANCY

1995 ◽  
Vol 03 (04) ◽  
pp. 483-496
Author(s):  
CHIU-CHENG CHANG ◽  
GERALDINE CHEN
Keyword(s):  
Critical Factors ◽  
The West ◽  
Survival And Growth

The ability to change is vital for corporate survival and growth and knowledge is the engine of change. While consultancy is generally associated with the West, we believe that the Asian heritage, particularly the Confucian reverence for knowledge and teachers, make Asian intellectuals best suited for performing the consultancy role effectively. But what exactly is the role of consultancy? What are the objectives and functions? And in what areas will Asian consultants stand out? Prospective Asian consultants must be able to marry Western and Eastern business cultures and practices. The critical factors for success as Asian international consultants will be examined.

Steady-state level of kit ligand mRNA in goat ovaries and the role of kit ligand in preantral follicle survival and growth in vitro

2009 ◽  
Vol 77 (3) ◽  
pp. 231-240 ◽  
Author(s):  
Juliana J.H. Celestino ◽  
Jamily B. Bruno ◽  
Isabel B. Lima-Verde ◽  
Maria Helena T. Matos ◽  
Mércia Viviane A. Saraiva ◽  
...  
Keyword(s):  
Steady State ◽  
State Level ◽  
Steady State Level ◽  
Preantral Follicle ◽  
Kit Ligand ◽  
Survival And Growth

scholarly journals Evolution of Networks of Protein Domain Organization

2020 ◽  
Author(s):  
M. Fayez Aziz ◽  
Gustavo Caetano-Anollés
Keyword(s):  
Dna Binding ◽  
Protein Function ◽  
Preferential Attachment ◽  
Big Bang ◽  
Binding Activity ◽  
Protein Domain ◽  
Domain Organization ◽  
Evolving Networks ◽  
Dna Binding Activity

Abstract Domains are the structural, functional and evolutionary units of proteins. They combine to form multidomain proteins. The evolutionary history of this molecular combinatorics has been studied with phylogenomic methods. Here, we construct networks of domain organization and explore their evolution. These networks revealed two ancient waves of structural novelty arising from ancient ‘p-loop’ and ‘winged helix’ domains and a massive ‘big bang’ of domain organization. The evolutionary recruitment of domains was highly modular, hierarchical and ongoing. Domain rearrangements elicited non-random and scale-free network structure. Comparative analyses of preferential attachment, randomness and modularity of networks showed yin-and-yang complementary transition patterns along the evolutionary timeline. Remarkably, evolving networks highlighted a central evolutionary role of cofactor-supporting structures of non-ribosomal peptide synthesis (NRPS) pathways, likely crucial to the early development of the genetic code. Some highly modular domains featured dual response regulation in two-component signal transduction systems with DNA-binding activity linked to transcriptional regulation of responses to environmental change. Interestingly, hub domains across the evolving networks shared the historical role of DNA binding and editing, an ancient protein function in molecular evolution. Our investigation unfolds historical source-sink patterns of evolutionary recruitment that further our understanding of protein architectures and functions.

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