scholarly journals Common Fundamentals of Psoriasis and Depression

2021 ◽  
Author(s):  
Stefanie Hölsken ◽  
Frederik Krefting ◽  
Manfred Schedlowski ◽  
Wiebke Sondermann
Keyword(s):  
Depressive Symptoms ◽  
Clinical Manifestations ◽  
Screening Tools ◽  
C Reactive Protein ◽  
Social Burden ◽  
Reactive Protein ◽  
Proinflammatory Mediators ◽  
Immune Mediated ◽  
Psychological Comorbidities ◽  
Substantial Degree

Psoriasis is an inflammatory, immune-mediated disease that is frequently associated with psychological comorbidities such as depression. The stigma patients feel because of the appearance of their skin may contribute to the high psycho-social burden of the disease. However, there is emerging evidence that overlapping biological mechanisms are, to a substantial degree, responsible for the close interaction between psoriasis and depression. Increased proinflammatory mediators such as C-reactive protein (CRP) or interleukin (IL)-6 are present in both psoriasis and depression indicating that inflammation may represent a pathophysiologic link between the diseases. Anti-inflammatory biologic therapies treat the clinical manifestations of psoriasis, but might also play a significant role in reducing associated depressive symptoms in psoriasis patients. Comparison between single studies focusing on the change of depressive symptoms in psoriasis is limited by inconsistency of the applied depression screening tools.

Intestinal dysbiosis in maltreated children is associated with concentrations of salivary cortisol, C-reactive protein and with depressive symptoms

2019 ◽  
Vol 107 ◽  
pp. 3
Author(s):  
Gergana Dimitrova Karaboycheva ◽  
Karin de Punder ◽  
Judith Overfeld ◽  
Peggy Dörr ◽  
Katja Dittrich ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Salivary Cortisol ◽  
C Reactive Protein ◽  
Maltreated Children ◽  
Reactive Protein ◽  
Intestinal Dysbiosis

scholarly journals Serum peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 in combination with C-reactive protein and white blood cell as novel predictors for infants with community-acquired pneumonia

2020 ◽  
Vol 18 ◽  
pp. 205873922094234
Author(s):  
Heng Xue ◽  
Hui Liu ◽  
Liangpu Xu ◽  
Qiaoling Liu ◽  
Bimin Zhuo ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Roc Curve ◽  
Predictive Value ◽  
Clinical Manifestations ◽  
Community Acquired Pneumonia ◽  
Enzyme Linked Immunosorbent Assay ◽  
C Reactive Protein ◽  
Roc Curve Analysis ◽  
Reactive Protein

The aim of this study was to investigate the predictive value of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) with C-reactive protein (CRP) and white blood cell (WBC) count for community-acquired pneumonia (CAP) in infants. A total of 84 hospitalized infants with CAP and 69 healthy infants were included in this study. The clinical manifestations and laboratory assay results of infants were recorded. Serum Pin1 level was estimated by enzyme-linked immunosorbent assay. The median serum Pin1 concentration in infants with CAP was significantly higher than that in controls (1.44 vs. 0.21 ng/mL, P < 0.0001). Receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curve (AUC) of the combination Pin1, CRP and WBC (Pin1 + CRP + WBC, 0.943) was higher than Pin1, CRP, WBC alone or the combination of Pin1 and CRP ( P < 0.05). The sensitivity of Pin1 + CRP + WBC (94.0%) was higher than that of Pin1, CRP, WBC alone, or any two combined ( P < 0.05). Pin1 + CRP + WBC also had a high negative predictive value (91.4%). Moreover, serum Pin1 alone had a high specificity (97.0%) and excellent positive predictive value (96.6%) for infants with CAP, which were higher than WBC, Pin1 and WBC in combination, CRP and WBC in combination, and Pin1 + CRP + WBC ( P < 0.05). Therefore, serum Pin 1 was highly expressed in infants with CAP and can singly or in combination with CRP and WBC represent promising novel predictors for infants with CAP.

Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression

2017 ◽  
Vol 62 ◽  
pp. 344-350 ◽  
Author(s):  
Ole Köhler-Forsberg ◽  
Henriette N. Buttenschøn ◽  
Katherine E. Tansey ◽  
Wolfgang Maier ◽  
Joanna Hauser ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Major Depression ◽  
Symptom Severity ◽  
Depression Symptom ◽  
C Reactive Protein ◽  
Reactive Protein

Effects of adjunctive N -acetylcysteine on depressive symptoms: Modulation by baseline high-sensitivity C-reactive protein

2018 ◽  
Vol 263 ◽  
pp. 268-274 ◽  
Author(s):  
Mauro Porcu ◽  
Mariana Ragassi Urbano ◽  
Waldiceu A. Verri ◽  
Decio Sabbatini Barbosa ◽  
Marcela Baracat ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Investigations into the lymphocyte phenotypes and the presence of rheumatoid factor and antinuclear antibody in the peripheral blood of 515 dogs

2012 ◽  
Vol 57 (No. 10) ◽  
pp. 529-535 ◽  
Author(s):  
K. Tamura ◽  
N. Nagashima ◽  
H. Oda ◽  
M. Kunimi ◽  
T. Itoi ◽  
...  
Keyword(s):  
Rheumatoid Factor ◽  
Antinuclear Antibody ◽  
Lymphocyte Subsets ◽  
Peripheral Lymphocyte ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Immune Mediated ◽  
Healthy Dogs ◽  
Lymphocyte Phenotypes

&nbsp; The levels of rheumatoid factor (RF), antinuclear antibody (ANA), and composition of peripheral lymphocyte subsets in 515 dogs were examined. Of these sample cases, 33 cases were diagnosed as immune-mediated fever that presented with high C-reactive protein (CRP), 31 cases were diagnosed with Hansen&rsquo;s Type 1 disc herniation and the remaining 415 cases were clinically healthy dogs, and served as controls. In the cases diagnosed with immune-mediated fever, 84% of the dogs tested positive to either RF or ANA (RF positive 60.6%; ANA positive 24.2%). By contrast, 16.2% of the healthy dogs were positive for either RF or ANA (RF positive 14.9%; ANA 1.3%). The CD4/CD8 ratio for peripheral lymphocyte was high for all analysed cases diagnosed with immune-mediated fever, and was significantly higher than those of healthy controls. These results indicate that the abnormal levels of lymphocytes may be an effective indicator for immune-mediated disease coupled to immune-mediated fever. &nbsp;

scholarly journals C-reactive protein in dogs with suspected bacterial diskospondylitis: 16 cases (2010–2019)

2020 ◽  
Vol 7 (1) ◽  
pp. e000386
Author(s):  
George Nye ◽  
Francois-Xavier Liebel ◽  
Tom Harcourt-Brown
Keyword(s):  
Back Pain ◽  
Antimicrobial Treatment ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Inflammatory Conditions ◽  
Immune Mediated ◽  
A Prospective Study ◽  
Serum Crp

ObjectivesC-reactive protein (CRP) is an acute phase protein used in multiple canine inflammatory conditions including steroid responsive meningitis-arteritis, immune-mediated polyarthritis and bronchopneumonia. The aim of this study was to assess whether serum CRP is elevated in cases of diskospondylitis.MethodsMedical records from 2010 to 2019 were searched to identify dogs diagnosed with diskospondylitis based on findings consistent on CT or MRI and with CRP tested.ResultsA total of 16 dogs met the inclusion criteria. All cases had back pain. Fourteen cases had elevated CRP, with a median value of 100.7 mg/l (reference range for CRP values: 0–10 mg/l), 12 were pyrexic and six had leucocytosis. The two dogs with normal CRP were normothermic and did not have leucocytosis. CRP was measured four to six weeks into antimicrobial treatment in eight of 14 dogs and was normal in all cases. One dog developed a suspected bacterial empyema diagnosed on MRI; this occurred two weeks after antibiotic treatment was discontinued based on a normal CRP level at follow-up.ConclusionsSerum CRP is elevated in cases of diskospondylitis and may be clinically more useful to screen dogs with back pain than pyrexia or leucocytosis alone. Further long-term clinical evaluation in a prospective study is needed to assess its use as a treatment monitoring tool and in decision making.

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