scholarly journals Diagnostic Value of Optical Coherence Tomography Image Features for Diagnosis of Basal Cell Carcinoma

2021 ◽  
Author(s):  
Fieke Adan ◽  
Klara Mosterd ◽  
Nicole W.J. Kelleners-Smeets ◽  
Patty J. Nelemans
Keyword(s):  
Optical Coherence Tomography ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Diagnostic Value ◽  
Image Features ◽  
Small Subset ◽  
Optical Coherence Tomography Image ◽  
Optical Coherence ◽  
Discriminative Ability

Optical coherence tomography (OCT) is a noninvasive diagnostic method. Numerous morphological OCT features have been described for diagnosis of basal cell carcinoma (BCC). In this study, we evaluate the diagnostic value of established features and we explore whether the use of a small set of features enables accurate discrimination between BCC and non-BCC lesions and between BCC subtypes. For each lesion, presence or absence of specific features was recorded. Histopathology was used as a gold standard. Diagnostic parameters were calculated for each feature and multivariate logistic regression analyses were performed to evaluate the loss in discriminative ability when using a small subset of features instead of all features that are characteristic for BCC according to literature. Results show that the use of a limited number of features allows for good discrimination of superficial BCC from non-superficial BCC and non-BCC lesions. The prevalence of BCC was 75.3% (225/299) and the proposed diagnostic algorithm enabled detection of 97.8% of BCC lesions (220/225). Subtyping without the need for biopsy was possible in 132 of 299 patients (44%) with a predictive value for presence of superficial BCC of 84.3% versus 98.8% for presence of non-superficial BCC.

scholarly journals Optical Coherence Tomography of Peri-Ocular Skin Cancers: An Optical Biopsy

2020 ◽  
pp. 1-9
Author(s):  
Sabrina Bergeron ◽  
Bryan Arthurs ◽  
Debra-Meghan Sanft ◽  
Christina Mastromonaco ◽  
Miguel N. Burnier Jr.
Keyword(s):  
Squamous Cell Carcinoma ◽  
Optical Coherence Tomography ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Skin Lesions ◽  
Sebaceous Carcinoma ◽  
Optical Coherence ◽  
Oct Imaging

<b><i>Introduction:</i></b> Optical coherence tomography (OCT) imaging has been used as a diagnostic tool for retinal disease for several years, and OCT apparatuses are becoming increasingly powerful. However, OCT has yet to reach its full potential in ophthalmology clinics. Alike retinal layers, it has been shown that OCT is able to generate cross-sectional images of the skin and allows visualization of skin lesions in a histopathology-like manner. <b><i>Objective:</i></b> We aim to validate OCT as an imaging modality for peri-ocular skin cancer. Through a series of cases, we highlight findings for 3 common eyelid malignancies: basal cell carcinoma, squamous cell carcinoma and sebaceous carcinoma. We propose an OCT image-based signature for basal cell carcinoma. <b><i>Methods:</i></b> This is a prospective study. Fifty-eight lesions suspicious of malignancy from 57 patients were subjected to OCT imaging prior to the surgical excision of the lesion. OCT images were analysed and scored according to previously identified OCT features. Eight representative examples are presented, highlighting the OCT patterns for each malignancy side by side to its corresponding histopathological sections. <b><i>Results:</i></b> Out of the 58 lesions analysed, 53 were malignant. A loss of the dermal-epidermal junction is observed in all malignant lesions. A strong link is observed between the presence of subepithelial hyporeflective nests on OCT and the diagnosis of basal cell carcinoma (present in 83% of cases). Conversely, lesions of epithelial origin such as squamous cell carcinoma are most often represented on OCT by acanthosis. Two supplementary cases, one basal cell carcinoma and one sebaceous carcinoma, are provided to illustrate how OCT imaging is a valuable tool in cases where clinical observations may be unusual. <b><i>Conclusions:</i></b> We provide evidence supporting the use of OCT for the evaluation of peri-ocular cancers. OCT enables visualization of the skin layers in vivo, before biopsy. Our results show that certain OCT features can contribute to include or exclude a diagnosis of basal cell carcinoma. By integrating this non-invasive imaging methodology into the routine assessment of peri-ocular skin lesions, especially in health care centres where access to specialists is limited, OCT imaging can increase clinical precision, reduce delays in patient referral and enhance patient care.

Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma

2004 ◽  
Vol 9 (2) ◽  
pp. 292 ◽  
Author(s):  
John Strasswimmer ◽  
Mark C. Pierce ◽  
B. Hyle Park ◽  
Victor Neel ◽  
Johannes F. de Boer
Keyword(s):  
Optical Coherence Tomography ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Optical Coherence

scholarly journals Optical Coherence Tomography for Noninvasive Diagnosis and Subtyping of Basal Cell Carcinoma: A Prospective Cohort Study

2020 ◽  
Vol 140 (10) ◽  
pp. 1962-1967
Author(s):  
Kelly A.E. Sinx ◽  
Eva van Loo ◽  
Erwin H.J. Tonk ◽  
Nicole W.J. Kelleners-Smeets ◽  
Veronique J.L. Winnepenninckx ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Cohort Study ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Prospective Cohort Study ◽  
Basal Cell ◽  
Prospective Cohort ◽  
Noninvasive Diagnosis ◽  
Optical Coherence
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