scholarly journals Life-long Skin Eruptions along Blaschko’s Lines in a 27-year-old Woman

2021 ◽  
Author(s):  
Takahiro Hamada ◽  
Kwesi Teye ◽  
Eri Katayama ◽  
Miyuki Kawamura ◽  
Hiroshi Koga ◽  
...  
Keyword(s):  
Blaschko’S Lines

Abstract is missing (Quiz)

scholarly journals Unilateral linear lichen planus hypertrophicus along blaschko's lines

2021 ◽  
Vol 12 (1) ◽  
pp. 185
Author(s):  
Priya Kapoor ◽  
Sumir Kumar ◽  
Meenakshi Batrani
Keyword(s):  
Lichen Planus ◽  
Blaschko’S Lines

scholarly journals Multiple aplasia cutis congenita lesions located along Blaschko's lines in a patient with tetralogy of Fallot-A

2012 ◽  
Vol 6 (2) ◽  
Author(s):  
Daiki Rokunohe ◽  
Eijiro Akasaka ◽  
Akiko Rokunohe ◽  
Takahide Kaneko ◽  
Yasushi Matsuzaki ◽  
...  
Keyword(s):  
Tetralogy Of Fallot ◽  
Aplasia Cutis Congenita ◽  
Blaschko’S Lines ◽  
Aplasia Cutis

sQuiz your knowledge: Unilateral linear hyperpigmented atrophic lesions along Blaschko's lines

2019 ◽  
Vol 29 (6) ◽  
pp. 681-682
Author(s):  
Li-wen Zhang ◽  
Juan Wu ◽  
Yong-hong Lu
Keyword(s):  
Blaschko’S Lines

scholarly journals Successful Treatment of Inflammatory Linear Verrucous Epidermal Nevus with Concomitant Psoriasis Using Etanercept

2018 ◽  
Vol 10 (1) ◽  
pp. 29-34
Author(s):  
Reda Hesham Saifaldeen ◽  
Mohammad I. Fatani ◽  
Badee Baltow ◽  
Abdulmajeed S. Khan
Keyword(s):  
Adverse Effects ◽  
Correct Diagnosis ◽  
Poor Response ◽  
Rare Form ◽  
Epidermal Nevus ◽  
Linear Distribution ◽  
Linear Path ◽  
Appropriate Therapy ◽  
Blaschko’S Lines ◽  
Linear Psoriasis

Linear psoriasis is a rare form of the disease characterized by the linear distribution of lesions involving dermatome or along Blaschko’s lines. Clinically, it may resemble inflammatory linear verrucous epidermal nevus; a combination of history, skin examination, and histopathology are required to ensure correct diagnosis and appropriate therapy. This paper describes a case of a 23-year-old male presenting with unilateral erythematous scaly plaques arranged in a linear path on the left leg. Etanercept was initiated after poor response to adalimumab. Improvement of his psoriasis was noted, with PASI 75 reduction after 24 weeks of treatment. Clinical studies have shown excellent efficacy of etanercept, and our patient well tolerated treatment with etanercept for 52 weeks without any adverse effects.

scholarly journals A Case of Familial Focal Dermal Hypoplasia: A Report of 3 Cases in Consecutive Generations

2018 ◽  
Vol 2 (5) ◽  
Author(s):  
David Ernesto Castillo ◽  
Nicole Nagrani ◽  
David Castillo ◽  
Rocio Reyes Muñoz ◽  
Mayerlis Cárdenas Guevara ◽  
...  
Keyword(s):  
Skin Lesions ◽  
Dominant Inheritance ◽  
Multisystem Disorder ◽  
Enamel Defects ◽  
Focal Dermal Hypoplasia ◽  
Uncommon Presentation ◽  
Goltz Syndrome ◽  
The Right ◽  
Blaschko’S Lines ◽  
Musculoskeletal Systems

Focal dermal hypoplasia (FDH), or Goltz syndrome, is a rare multisystem disorder affecting mesodermal and ectodermal structures, with the skin, eyes, teeth, and musculoskeletal systems most commonly affected. FDH results from mutations in the PORCN gene. Ninety-five percent of cases arise from novo mutations, whereas 5% are hereditary with an X-linked dominant inheritance pattern. Here, we describe an uncommon presentation of FDH in three consecutive generations. Patient 1 is an 8-month-old female born of non-consanguineous marriage who presented with diffuse alopecia of the scalp, linear hypopigmented, atrophic papules, and plaques with peripheral hyperpigmentation on the left hemiabdomen and right lateral leg along Blaschko's lines as well as syndactyly of the right second and third toes. Skin biopsy from the abdomen showed a thin epidermis with flattened rete ridges and massive dermal edema within collagen fibers and reactive capillaries. Family history was significant for similar skin lesions and bone deformities in her mother and similar skin lesions in her grandmother. Patient 2 (patient 1’s mother) is a 17-year-old female with similar linear hypopigmented, atrophic plaques with peripheral hyperpigmentation on the abdomen and right axilla, syndactyly of the right hand, patchy alopecia of the scalp, microdontia, teeth fusion, enamel defects, verrucous papillomas in the axillae and onycholysis. Patient 3 (patient 1’s grandmother), presented with similar hypopigmented, atrophic plaques on the abdomen and left arm.

scholarly journals Mosaic trisomy 8 detected by fibroblasts cultured of skin

2016 ◽  
pp. 100-104 ◽  
Author(s):  
Gustavo Adolfo Giraldo Ospina ◽  
Ana Milena Gómez Camacho ◽  
Lina Maria Mora Barreto ◽  
Fernando Suarez Obando ◽  
Olga María Moreno Niño
Keyword(s):  
Peripheral Blood ◽  
Phenotypic Variability ◽  
Clinical Findings ◽  
Trisomy 8 ◽  
Cutaneous Lesions ◽  
Congenital Origin ◽  
The Right ◽  
Blaschko’S Lines ◽  
Cutaneous Mosaicism ◽  
Mosaic Trisomy

Introduction: Mosaic trisomy 8 or "Warkany's Syndrome" is a chromosomopathy with an estimated prevalance of 1:25,000 to 1:50,000, whose clinical presentation has a wide phenotypic variability. Case Description: Patient aged 14 years old with antecedents of global retardation of development, moderate cognitive deficit and hypothyroidism of possible congenital origin. Clinical Findings: Physical examination revealed palpebral ptosis, small corneas and corectopia, hypoplasia of the upper maxilla and prognathism, dental crowding, high-arched palate, anomalies of the extremities such as digitalization of the thumbs, clinodactyly and bilateral shortening of the fifth finger, shortening of the right femur, columnar deviation and linear brown blotches that followed Blaschko's lines. Cerebral nuclear magnetic resonance revealed type 1 Chiari's malformation and ventriculomegaly. Although the karyotype was normal in peripheral blood (46,XY), based on the finding of cutaneous mosaicism the lesions were biopsied and cytogenetic analysis demonstrated mosaic trisomy 8: mos 47,XY,+8[7]/46,XY[93]. Clinical Relevance: Trisomy 8 is clinically presented as a mosaic, universal cases being unfailingly lethal. In this particular case, cutaneous lesions identified the mosaic in tissue, although the karyotype was normal in peripheral blood. The cutaneous mosaicism represented by brown linear blotches which follow Blaschko's lines is a clinical finding that has not previously been described in Warkany's syndrome.

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