Importance of Intestinal Environment and Cellular Plasticity of Islets in the Development of Postpancreatectomy Diabetes

Diabetes Care ◽  
2021 ◽  
Vol 44 (4) ◽  
pp. 1002-1011
Author(s):  
Tatsuya Fukuda ◽  
Ryotaro Bouchi ◽  
Takato Takeuchi ◽  
Kikuko Amo-Shiinoki ◽  
Atsushi Kudo ◽  
...  
Keyword(s):  
Cellular Plasticity ◽  
Intestinal Environment

231-LB: Importance of Intestinal Environment and Cellular Plasticity of Beta Cells in the Development of Post-Pancreatectomy Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 231-LB
Author(s):  
RYOTARO BOUCHI ◽  
TATSUYA FUKUDA ◽  
TAKATO TAKEUCHI ◽  
KIKUKO AMO-SHIINOKI ◽  
KATSUYA TANABE ◽  
...  
Keyword(s):  
Beta Cells ◽  
Cellular Plasticity ◽  
Intestinal Environment

scholarly journals Histone Degradation by the Proteasome Regulates Chromatin and Cellular Plasticity

FEBS Journal ◽  
2021 ◽  
Author(s):  
Merav D. Shmueli ◽  
Daoud Sheban ◽  
Avital Eisenberg‐Lerner ◽  
Yifat Merbl
Keyword(s):  
Cellular Plasticity

Cellular plasticity in kidney injury and repair

2016 ◽  
Vol 13 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Monica Chang-Panesso ◽  
Benjamin D. Humphreys
Keyword(s):  
Kidney Injury ◽  
Cellular Plasticity ◽  
Injury And Repair

scholarly journals How Neural Crest Transcription Factors Contribute to Melanoma Heterogeneity, Cellular Plasticity, and Treatment Resistance

2021 ◽  
Vol 22 (11) ◽  
pp. 5761
Author(s):  
Anja Wessely ◽  
Theresa Steeb ◽  
Carola Berking ◽  
Markus Vincent Heppt
Keyword(s):  
Drug Resistance ◽  
Neural Crest ◽  
Physiological Function ◽  
Acquired Resistance ◽  
Treatment Resistance ◽  
Transcriptional Regulators ◽  
Disease Stage ◽  
Cellular Plasticity ◽  
Embryonic Origin ◽  
Promote Disease Progression

Cutaneous melanoma represents one of the deadliest types of skin cancer. The prognosis strongly depends on the disease stage, thus early detection is crucial. New therapies, including BRAF and MEK inhibitors and immunotherapies, have significantly improved the survival of patients in the last decade. However, intrinsic and acquired resistance is still a challenge. In this review, we discuss two major aspects that contribute to the aggressiveness of melanoma, namely, the embryonic origin of melanocytes and melanoma cells and cellular plasticity. First, we summarize the physiological function of epidermal melanocytes and their development from precursor cells that originate from the neural crest (NC). Next, we discuss the concepts of intratumoral heterogeneity, cellular plasticity, and phenotype switching that enable melanoma to adapt to changes in the tumor microenvironment and promote disease progression and drug resistance. Finally, we further dissect the connection of these two aspects by focusing on the transcriptional regulators MSX1, MITF, SOX10, PAX3, and FOXD3. These factors play a key role in NC initiation, NC cell migration, and melanocyte formation, and we discuss how they contribute to cellular plasticity and drug resistance in melanoma.

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