231-LB: Importance of Intestinal Environment and Cellular Plasticity of Beta Cells in the Development of Post-Pancreatectomy Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 231-LB
Author(s):  
RYOTARO BOUCHI ◽  
TATSUYA FUKUDA ◽  
TAKATO TAKEUCHI ◽  
KIKUKO AMO-SHIINOKI ◽  
KATSUYA TANABE ◽  
...  
Keyword(s):  
Beta Cells ◽  
Cellular Plasticity ◽  
Intestinal Environment

Importance of Intestinal Environment and Cellular Plasticity of Islets in the Development of Postpancreatectomy Diabetes

Diabetes Care ◽  
2021 ◽  
Vol 44 (4) ◽  
pp. 1002-1011
Author(s):  
Tatsuya Fukuda ◽  
Ryotaro Bouchi ◽  
Takato Takeuchi ◽  
Kikuko Amo-Shiinoki ◽  
Atsushi Kudo ◽  
...  
Keyword(s):  
Cellular Plasticity ◽  
Intestinal Environment

Endodermal progenitor cells (EPCs) as an extensive source for human endocrine beta-cells

2014 ◽  
Vol 52 (08) ◽  
Author(s):  
A Illing ◽  
M Hohwieler ◽  
T Seufferlein ◽  
A Kleger
Keyword(s):  
Progenitor Cells ◽  
Beta Cells

Osteoprotegerin (OPG) protects pancreatic beta cells from Interleukin-1 induced cell death

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
J Schrader ◽  
U Niebergall ◽  
M Schoppet ◽  
D Hörsch ◽  
LC Hofbauer
Keyword(s):  
Cell Death ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Interleukin 1

Glucose-dependent expansion of pancreatic beta-cells by the protein p8 in vitro and in vivo

2007 ◽  
Vol 115 (S 1) ◽  
Author(s):  
G Päth ◽  
A Opel ◽  
M Gehlen ◽  
V Rothhammer ◽  
X Niu ◽  
...  
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells

Iron status in diabetes mellitus

2019 ◽  
pp. 7-12
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cells ◽  
Defense Mechanism ◽  
Acute Stress ◽  
Islet Cells ◽  
Iron Status ◽  
Acute Phase Reactant ◽  
Iron Deposition ◽  
Muscle Tissues ◽  
High Production

Diabetes mellitus can be defined as chronic metabolic disease which results from either relative or complete absence of insulin by the pancreatic beta islet cells. This in-turn may lead to hyperglycemia due to disturbances in the metabolism of glucose. In the human body, iron is con- sidered to be an effective pro-oxidant and participates in the generation of reactive oxygen species (ROS) such as hydroxyl radical. Because of the poor antioxidant defense mechanism of beta cells (low production of antioxidant enzymes such as catalase, glutathione peroxidase and dismutase), so they are highly prone to iron-induced oxidative stress and iron deposition in it and this will lead to apoptosis, and subsequently insulin deficiency. This iron deposition in beta cells will also lead to insulin resistance by reducing insulin extracting ability of the liver and inhibiting glucose uptake in muscle tissues and fats, this in turn will result in high production of hepatic glucose. Ferritin which is an acute phase reactant protein, that responds to acute stress like trauma, infections, tissue necrosis and surgery, it can produce diabetes mellitus either through inflammation or by increasing iron stores.

Use of 3D culture systems to generate human induced pluripotent stem cell-derived [beta]-cells in vitro

2018 ◽  
Author(s):  
Fantuzzi Federica ◽  
Toivonen Sanna ◽  
Schiavo Andrea Alex ◽  
Pachera Nathalie ◽  
Rajaei Bahareh ◽  
...  
Keyword(s):  
Stem Cell ◽  
Beta Cells ◽  
Pluripotent Stem Cell ◽  
3D Culture ◽  
Induced Pluripotent Stem Cell ◽  
Culture Systems ◽  
Induced Pluripotent
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