scholarly journals Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to Diabetes Incidence Among American Young Adults: A 30-Year Follow-up Study

Diabetes Care ◽  
2020 ◽  
Vol 43 (10) ◽  
pp. 2426-2434
Author(s):  
Jie Zhu ◽  
Cheng Chen ◽  
Liping Lu ◽  
Kefeng Yang ◽  
Jared Reis ◽  
...  
Keyword(s):  
Young Adults ◽  
Vitamin B12 ◽  
Vitamin B6 ◽  
Diabetes Incidence ◽  
Follow Up Study ◽  
American Young Adults

scholarly journals Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to Diabetes Incidence among American Young Adults: A 30-year Follow-up Study

2020 ◽  
Author(s):  
Jie Zhu ◽  
Cheng Chen ◽  
Liping Lu ◽  
Kefeng Yang ◽  
Jared Reis ◽  
...  
Keyword(s):  
Young Adults ◽  
Vitamin B12 ◽  
Vitamin B6 ◽  
Dietary Assessment ◽  
Folate Intake ◽  
Oral Glucose ◽  
Diabetes Incidence ◽  
Dietary History ◽  
Incident Cases

<b>OBJECTIVE </b> <p>To prospectively examine intakes of folate, vitamin B6, and vitamin B12 in relation to diabetes incidence in a large U.S. cohort.</p> <p><b>RESEARCH DESIGN AND METHODS </b></p> <p>A total of 4,704 American adults aged 18-30 years and without diabetes were enrolled in 1985-86 and followed until 2015-16 in the Coronary Artery Risk Development in Young Adults study. Dietary assessment was conducted by a validated dietary-history questionnaire at baseline, in 1992-93 and 2005-06. The cumulative average intakes of folate, vitamin B6, and vitamin B12 were used in the analyses. Incident diabetes was ascertained by plasma glucose levels, oral glucose tolerance tests, hemoglobin A1<sub>C</sub> concentrations, and/or anti-diabetic medications.</p> <p><b>RESULTS </b></p> <p>During 30 years (mean = 20.5±8.9 years) follow-up, 655 incident cases of diabetes occurred. Intake of folate, but not vitamin B6 or vitamin B12, was inversely associated with diabetes incidence after adjustment for potential confounders. Compared to the lowest quintile of total folate intake, the multivariable-adjusted hazard ratios (95% confidence interval) in quintile 2 to 5 were 0.85 (0.67-1.08), 0.78 (0.60-1.02), 0.82 (0.62-1.09), and 0.70 (0.51-0.97); <i>P</i><sub>trend</sub> = 0.02. Higher folate intake was also associated with lower plasma homocysteine (<i>P</i><sub>trend</sub> <0.01) and insulin (<i>P</i><sub>trend </sub><0.01). Among supplement users, folate intake was inversely associated with serum C-reactive protein levels (<i>P</i><sub>trend </sub><0.01). </p> <p><b>CONCLUSIONS </b></p> <p>Intake of folate in young adulthood was inversely associated with diabetes incidence in midlife among Americans. The observed association may be partially explained by mechanisms related to homocysteine level, insulin sensitivity, and systemic inflammation.</p>

scholarly journals Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to Diabetes Incidence among American Young Adults: A 30-year Follow-up Study

2020 ◽  
Author(s):  
Jie Zhu ◽  
Cheng Chen ◽  
Liping Lu ◽  
Kefeng Yang ◽  
Jared Reis ◽  
...  
Keyword(s):  
Young Adults ◽  
Vitamin B12 ◽  
Vitamin B6 ◽  
Dietary Assessment ◽  
Folate Intake ◽  
Oral Glucose ◽  
Diabetes Incidence ◽  
Dietary History ◽  
Incident Cases

<b>OBJECTIVE </b> <p>To prospectively examine intakes of folate, vitamin B6, and vitamin B12 in relation to diabetes incidence in a large U.S. cohort.</p> <p><b>RESEARCH DESIGN AND METHODS </b></p> <p>A total of 4,704 American adults aged 18-30 years and without diabetes were enrolled in 1985-86 and followed until 2015-16 in the Coronary Artery Risk Development in Young Adults study. Dietary assessment was conducted by a validated dietary-history questionnaire at baseline, in 1992-93 and 2005-06. The cumulative average intakes of folate, vitamin B6, and vitamin B12 were used in the analyses. Incident diabetes was ascertained by plasma glucose levels, oral glucose tolerance tests, hemoglobin A1<sub>C</sub> concentrations, and/or anti-diabetic medications.</p> <p><b>RESULTS </b></p> <p>During 30 years (mean = 20.5±8.9 years) follow-up, 655 incident cases of diabetes occurred. Intake of folate, but not vitamin B6 or vitamin B12, was inversely associated with diabetes incidence after adjustment for potential confounders. Compared to the lowest quintile of total folate intake, the multivariable-adjusted hazard ratios (95% confidence interval) in quintile 2 to 5 were 0.85 (0.67-1.08), 0.78 (0.60-1.02), 0.82 (0.62-1.09), and 0.70 (0.51-0.97); <i>P</i><sub>trend</sub> = 0.02. Higher folate intake was also associated with lower plasma homocysteine (<i>P</i><sub>trend</sub> <0.01) and insulin (<i>P</i><sub>trend </sub><0.01). Among supplement users, folate intake was inversely associated with serum C-reactive protein levels (<i>P</i><sub>trend </sub><0.01). </p> <p><b>CONCLUSIONS </b></p> <p>Intake of folate in young adulthood was inversely associated with diabetes incidence in midlife among Americans. The observed association may be partially explained by mechanisms related to homocysteine level, insulin sensitivity, and systemic inflammation.</p>

scholarly journals Fasting Insulin Level Is Positively Associated With Incidence of Hypertension Among American Young Adults: A 20-year follow-up study

Diabetes Care ◽  
2012 ◽  
Vol 35 (7) ◽  
pp. 1532-1537 ◽  
Author(s):  
P. Xun ◽  
K. Liu ◽  
W. Cao ◽  
S. Sidney ◽  
O. D. Williams ◽  
...  
Keyword(s):  
Young Adults ◽  
Insulin Level ◽  
Fasting Insulin ◽  
Follow Up Study ◽  
Fasting Insulin Level ◽  
American Young Adults

scholarly journals Folate intake and incidence of hypertension among American young adults: a 20-y follow-up study

2012 ◽  
Vol 95 (5) ◽  
pp. 1023-1030 ◽  
Author(s):  
Pengcheng Xun ◽  
Kiang Liu ◽  
Catherine M Loria ◽  
Deborah Bujnowski ◽  
James M Shikany ◽  
...  
Keyword(s):  
Young Adults ◽  
Folate Intake ◽  
Follow Up Study ◽  
American Young Adults

scholarly journals Magnesium intake is inversely associated with risk of obesity in a 30-year prospective follow-up study among American young adults

2020 ◽  
Vol 59 (8) ◽  
pp. 3745-3753 ◽  
Author(s):  
Liping Lu ◽  
Cheng Chen ◽  
Kefeng Yang ◽  
Jie Zhu ◽  
Pengcheng Xun ◽  
...  
Keyword(s):  
Young Adults ◽  
Magnesium Intake ◽  
Follow Up Study ◽  
American Young Adults

Psychotropic medication use among personality disordered young adults. A follow-up study among former adolescent psychiatric inpatients

2020 ◽  
Vol 293 ◽  
pp. 113449
Author(s):  
Liisa Kantojärvi ◽  
Helinä Hakko ◽  
Milla Mukka ◽  
Anniina Käyhkö ◽  
Pirkko Riipinen ◽  
...  
Keyword(s):  
Young Adults ◽  
Psychotropic Medication ◽  
Medication Use ◽  
Psychiatric Inpatients ◽  
Follow Up Study ◽  
Personality Disordered

Triple Innominate Osteotomy in Young Adults for the Treatment of Acetabular Dysplasia: A 9-Year Follow-Up Study

Orthopedics ◽  
2001 ◽  
Vol 24 (6) ◽  
pp. 565-569
Author(s):  
Christopher L Peters ◽  
Brian W Fukushima ◽  
Tammy K Park ◽  
Sherman S Coleman ◽  
Harold K Dunn
Keyword(s):  
Young Adults ◽  
Acetabular Dysplasia ◽  
Follow Up Study ◽  
Innominate Osteotomy
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