scholarly journals Nocturnal Blood Pressure Is Associated With Cerebral Small-Vessel Disease in Type 1 Diabetes

Diabetes Care ◽  
2020 ◽  
Vol 43 (8) ◽  
pp. e96-e98
Author(s):  
Marika I. Eriksson ◽  
Daniel Gordin ◽  
Sara Shams ◽  
Carol Forsblom ◽  
Paula Summanen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease ◽  
Nocturnal Blood Pressure

scholarly journals Cerebral small-vessel disease is associated with the severity of diabetic retinopathy in type 1 diabetes

2021 ◽  
Vol 9 (1) ◽  
pp. e002274
Author(s):  
Marika I Eriksson ◽  
Paula Summanen ◽  
Daniel Gordin ◽  
Carol Forsblom ◽  
Sara Shams ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Small Vessel Disease ◽  
Brain Mri ◽  
Cerebral Small Vessel Disease ◽  
Cerebral Microbleeds ◽  
Small Vessel ◽  
Vessel Disease

IntroductionCerebral small-vessel disease is common in neurologically asymptomatic individuals with type 1 diabetes. The retinal vasculature is thought to mirror the brain’s vasculature, but data on this association are limited in type 1 diabetes. Our aim was to study associations between diabetic retinopathy severity and cerebral small-vessel disease in type 1 diabetes.Research design and methodsFor this cross-sectional study, we enrolled 189 participants with type 1 diabetes (median age 40 (33–45) years; 53% female; diabetes duration 21.6 (18.2–30.7) years) and 29 healthy age-matched and sex-matched controls as part of the Finnish Diabetic Nephropathy Study. Participants underwent a clinical investigation, brain MRI, and fundus imaging. Signs of cerebral small-vessel disease in brain MRIs were analyzed in relation to diabetic retinopathy severity (Early Treatment Diabetic Retinopathy Study (ETDRS) score).ResultsIn type 1 diabetes, participants with cerebral small-vessel disease had higher ETDRS scores (35 (20–61) vs 20 (20–35), p=0.022) and a higher prevalence of proliferative diabetic retinopathy than those without cerebral small-vessel disease (25% vs 9%, p=0.002). In adjusted analysis, proliferative diabetic retinopathy was associated with cerebral small-vessel disease (OR 2.57 (95% CI 1.04 to 6.35)). Median ETDRS score (35 (20–65) vs 20 (20–35), p=0.024) and proliferative diabetic retinopathy prevalence were higher (29% vs 13%, p=0.002) in participants with versus without cerebral microbleeds. ETDRS scores increased by number of cerebral microbleeds (p=0.001), both ETDRS score (OR 1.05 (95% CI 1.02 to 1.09)) and proliferative diabetic retinopathy (8.52 (95% CI 1.91 to 37.94)) were associated with >2 cerebral microbleeds in separate multivariable analysis. We observed no association with white matter hyperintensities or lacunar infarcts.ConclusionsPresence of cerebral small-vessel disease on brain MRI, particularly cerebral microbleeds, is associated with the severity of diabetic retinopathy.

scholarly journals Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes

Diabetes Care ◽  
2018 ◽  
Vol 42 (2) ◽  
pp. 327-330 ◽  
Author(s):  
Lena M. Thorn ◽  
Sara Shams ◽  
Daniel Gordin ◽  
Ron Liebkind ◽  
Carol Forsblom ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease ◽  
Mri Features

Ambulatory Blood Pressure Levels in the Prediction of Progression of Cerebral Small Vessel Disease

2020 ◽  
Vol 68 (10) ◽  
pp. 2232-2239
Author(s):  
Joan Jiménez‐Balado ◽  
Iolanda Riba‐Llena ◽  
Olga Maisterra ◽  
Jesús Pizarro ◽  
Antoni Palasí ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Ambulatory Blood Pressure ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Blood pressure and sodium: Association with MRI markers in cerebral small vessel disease

2015 ◽  
Vol 36 (1) ◽  
pp. 264-274 ◽  
Author(s):  
Anna K Heye ◽  
Michael J Thrippleton ◽  
Francesca M Chappell ◽  
Maria del C Valdés Hernández ◽  
Paul A Armitage ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Salt Intake ◽  
Small Vessel Disease ◽  
Sodium Concentration ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Plasma Sodium ◽  
Dietary Salt ◽  
Vessel Disease ◽  
Plasma Sodium Concentration

Dietary salt intake and hypertension are associated with increased risk of cardiovascular disease including stroke. We aimed to explore the influence of these factors, together with plasma sodium concentration, in cerebral small vessel disease (SVD). In all, 264 patients with nondisabling cortical or lacunar stroke were recruited. Patients were questioned about their salt intake and plasma sodium concentration was measured; brain tissue volume and white-matter hyperintensity (WMH) load were measured using structural magnetic resonance imaging (MRI) while diffusion tensor MRI and dynamic contrast-enhanced MRI were acquired to assess underlying tissue integrity. An index of added salt intake ( P = 0.021), pulse pressure ( P = 0.036), and diagnosis of hypertension ( P = 0.0093) were positively associated with increased WMH, while plasma sodium concentration was associated with brain volume ( P = 0.019) but not with WMH volume. These results are consistent with previous findings that raised blood pressure is associated with WMH burden and raise the possibility of an independent role for dietary salt in the development of cerebral SVD.

scholarly journals Day-to-Day Home Blood Pressure Variability is Associated with Cerebral Small Vessel Disease Burden in a Memory Clinic Population

2020 ◽  
Vol 74 (2) ◽  
pp. 463-472 ◽  
Author(s):  
Rianne A.A. de Heus ◽  
Stacha F.I. Reumers ◽  
Alba van der Have ◽  
Maxime Tumelaire ◽  
Phillip J. Tully ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Disease Burden ◽  
Small Vessel Disease ◽  
Home Blood Pressure ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Memory Clinic ◽  
Vessel Disease ◽  
Clinic Population

Blood pressure variability and leukoaraiosis amount in cerebral small-vessel disease

2001 ◽  
Vol 104 (6) ◽  
pp. 358-363 ◽  
Author(s):  
J. Martí-Fàbregas ◽  
C. Valencia ◽  
J. Pujol ◽  
C. García-Sánchez ◽  
A. Roca-Cusachs ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease
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