Ambulatory Blood Pressure Levels in the Prediction of Progression of Cerebral Small Vessel Disease

2020 ◽  
Vol 68 (10) ◽  
pp. 2232-2239
Author(s):  
Joan Jiménez‐Balado ◽  
Iolanda Riba‐Llena ◽  
Olga Maisterra ◽  
Jesús Pizarro ◽  
Antoni Palasí ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Ambulatory Blood Pressure ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Impact of the ambulatory blood pressure monitoring profile on cognitive and imaging findings of cerebral small-vessel disease in older adults with cognitive complaints

2021 ◽  
Author(s):  
Yong S. Shim ◽  
Hae-Eun Shin
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Ambulatory Blood Pressure ◽  
Small Vessel Disease ◽  
Mmse Score ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Cognitive Complaints ◽  
Mri Findings ◽  
Vessel Disease

AbstractWe investigated ambulatory blood pressure (BP) monitoring (ABPM) profiles and magnetic resonance imaging (MRI) findings of cerebral small-vessel disease (cSVD) in older adults with cognitive complaints who were grouped as follows: subjective cognitive decline, mild cognitive impairment, and dementia of Alzheimer’s type. Group comparisons and correlation analyses among demographic characteristics, cognitive and MRI findings, and ABPM profiles were performed. Furthermore, multivariate logistic regression analyses for dependent variables of (1) dementia or not and (2) MRI criteria of subcortical vascular dementia (SVaD) or not were conducted with independent variables of dichotomized ABPM profiles. A total of 174 subjects (55 males and 119 females) were included: mean age 75.36 ± 7.13 years; Mini-Mental State Examination (MMSE) score 20.51 ± 6.23. No MRI and ABPM findings except medial temporal atrophy were different between three groups. Twenty-four-hour systolic BP (sBP) was correlated with MMSE score (r = –0.182; p = 0.022) and the severity of white matter hyperintensity (WMH) (r = 0.157; p = 0.048). A higher daytime sBP was associated with dementia (odds ratio (OR): 3.734; 95% confidence interval (CI): 1.041–13.390; p = 0.043) and MRI finding of SVaD (OR: 10.543; 95% CI: 1.161–95.740; p = 0.036). Although there were no differences in ABPM profiles between three groups, a higher BP—especially a higher sBP—correlated with cognitive dysfunction and severity of WMH in older adults. Only higher daytime sBP was an independent predictor for dementia and MRI findings of SVaD. Among various ABPM profiles in this study, a higher BP, especially a higher sBP, may be considered the most important for clinical and MRI findings of cSVD.

scholarly journals Blood pressure and sodium: Association with MRI markers in cerebral small vessel disease

2015 ◽  
Vol 36 (1) ◽  
pp. 264-274 ◽  
Author(s):  
Anna K Heye ◽  
Michael J Thrippleton ◽  
Francesca M Chappell ◽  
Maria del C Valdés Hernández ◽  
Paul A Armitage ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Salt Intake ◽  
Small Vessel Disease ◽  
Sodium Concentration ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Plasma Sodium ◽  
Dietary Salt ◽  
Vessel Disease ◽  
Plasma Sodium Concentration

Dietary salt intake and hypertension are associated with increased risk of cardiovascular disease including stroke. We aimed to explore the influence of these factors, together with plasma sodium concentration, in cerebral small vessel disease (SVD). In all, 264 patients with nondisabling cortical or lacunar stroke were recruited. Patients were questioned about their salt intake and plasma sodium concentration was measured; brain tissue volume and white-matter hyperintensity (WMH) load were measured using structural magnetic resonance imaging (MRI) while diffusion tensor MRI and dynamic contrast-enhanced MRI were acquired to assess underlying tissue integrity. An index of added salt intake ( P = 0.021), pulse pressure ( P = 0.036), and diagnosis of hypertension ( P = 0.0093) were positively associated with increased WMH, while plasma sodium concentration was associated with brain volume ( P = 0.019) but not with WMH volume. These results are consistent with previous findings that raised blood pressure is associated with WMH burden and raise the possibility of an independent role for dietary salt in the development of cerebral SVD.

scholarly journals Day-to-Day Home Blood Pressure Variability is Associated with Cerebral Small Vessel Disease Burden in a Memory Clinic Population

2020 ◽  
Vol 74 (2) ◽  
pp. 463-472 ◽  
Author(s):  
Rianne A.A. de Heus ◽  
Stacha F.I. Reumers ◽  
Alba van der Have ◽  
Maxime Tumelaire ◽  
Phillip J. Tully ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Disease Burden ◽  
Small Vessel Disease ◽  
Home Blood Pressure ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Memory Clinic ◽  
Vessel Disease ◽  
Clinic Population

Blood pressure variability and leukoaraiosis amount in cerebral small-vessel disease

2001 ◽  
Vol 104 (6) ◽  
pp. 358-363 ◽  
Author(s):  
J. Martí-Fàbregas ◽  
C. Valencia ◽  
J. Pujol ◽  
C. García-Sánchez ◽  
A. Roca-Cusachs ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease
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