scholarly journals Bariatric Surgery in Patients With Obesity and Latent Autoimmune Diabetes in Adults (LADA)

Diabetes Care ◽  
2020 ◽  
Vol 43 (5) ◽  
pp. e56-e57 ◽  
Author(s):  
Ali Aminian ◽  
Gautam Sharma ◽  
Rickesha L. Wilson ◽  
Sangeeta R. Kashyap ◽  
Emanuele Lo Menzo ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Autoimmune Diabetes ◽  
Latent Autoimmune Diabetes

scholarly journals Latent Autoimmune Diabetes in Adults Presenting as Diabetes "Recurrence" After Bariatric Surgery: A Case Report

Diabetes Care ◽  
2013 ◽  
Vol 36 (8) ◽  
pp. e120-e120 ◽  
Author(s):  
S. B. Manning ◽  
A. Pucci ◽  
R. L. Batterham ◽  
N. Finer
Keyword(s):  
Bariatric Surgery ◽  
Case Report ◽  
Autoimmune Diabetes ◽  
Latent Autoimmune Diabetes ◽  
Diabetes Recurrence

scholarly journals Bariatric Surgery Outcomes in Patients with Latent Autoimmune Diabetes of the Adult

Obesity Facts ◽  
2021 ◽  
pp. 1-6
Author(s):  
Marta Guimarães ◽  
Sofia S. Pereira ◽  
Mário Nora ◽  
Mariana P. Monteiro
Keyword(s):  
Bariatric Surgery ◽  
Autoimmune Diabetes ◽  
Insulin Dose ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Preoperative Body Mass Index ◽  
Insulin Requirements ◽  
Daily Insulin Dose ◽  
Latent Autoimmune Diabetes ◽  
Sustained Weight Loss

Bariatric surgery is a very effective treatment for obesity-associated type 2 diabetes. However, the benefits of bariatric surgery in patients with obesity and autoimmune diabetes, such as type 1 diabetes and latent autoimmune diabetes in adults (LADA), are controversial. We report 3 female patients with obesity and LADA who underwent laparoscopic Roux-en-Y gastric bypass &#x3e;10 years ago. The patients were diagnosed with LADA both 1 and 9 years before (<i>n</i> = 2) or 11 years after the surgery (<i>n</i> = 1). Patients preoperative body mass index ranged from 36 to 47 kg/m<sup>2</sup> and improved to 23–37 kg/m<sup>2</sup> in the last follow-up visit, 10–15 years after surgery. Daily insulin dose also decreased from an average of 0.68 to 0.45 IU/kg in those patients treated with insulin before bariatric surgery. Only one patient developed diabetes-related target organ damage. This study shows that patients with LADA depict remarkable reduction of body weight and insulin requirements over long-term after bariatric surgery. So, LADA should not be considered a contraindication for bariatric surgery yet should only be recommended for patients with concomitant obesity with the primary aim of achieving sustained weight loss.

Abstract #265 Clinical Characteristic of 31 Patients Diagnosed with Latent Autoimmune Diabetes in Adults (Lada) in a Multicentric Study in Mexico

2019 ◽  
Vol 25 ◽  
pp. 103
Author(s):  
Raquel Faradji ◽  
Carmen Castillo-Galindo ◽  
Natalia De la Garza-Hernandez ◽  
Sigfrido Miracle-Lopez ◽  
Claudia Ramirez-Renteria ◽  
...  
Keyword(s):  
Autoimmune Diabetes ◽  
Multicentric Study ◽  
Latent Autoimmune Diabetes ◽  
Clinical Characteristic

Type 1 Diabetes-related Autoantibodies in Different Forms of Diabetes

2019 ◽  
Vol 15 (3) ◽  
pp. 199-204 ◽  
Author(s):  
Elin Pettersen Sørgjerd
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Autoimmune Diabetes ◽  
Acid Decarboxylase ◽  
Adult Onset ◽  
Latent Autoimmune Diabetes ◽  
Childhood Type 1 Diabetes ◽  
Childhood Type

Autoantibodies against Glutamic Acid Decarboxylase (GADA), insulinoma antigen-2 (IA- 2A), insulin (IAA) and the most recently Zinc Transporter 8 (ZnT8A) are one of the most reliable biomarkers for autoimmune diabetes in both children and adults. They are today the only biomarkers that can distinguish Latent Autoimmune Diabetes in Adults (LADA) from phenotypically type 2 diabetes. As the frequency of autoantibodies at diagnosis in childhood type 1 diabetes depends on age, GADA is by far the most common in adult onset autoimmune diabetes, especially LADA. Being multiple autoantibody positive have also shown to be more common in childhood diabetes compared to adult onset diabetes, and multiple autoantibody positivity have a high predictive value of childhood type 1 diabetes. Autoantibodies have shown inconsistent results to predict diabetes in adults. Levels of autoantibodies are reported to cause heterogeneity in LADA. Reports indicate that individuals with high levels of autoantibodies have a more type 1 diabetes like phenotype and individuals with low levels of autoantibody positivity have a more type 2 diabetes like phenotype. It is also well known that autoantibody levels can fluctuate and transient autoantibody positivity in adult onset autoimmune diabetes have been reported to affect the phenotype.

A form of Autoimmune Diabetes in Adults Named LADA – An Update on Essential Features and Controversies

2019 ◽  
Vol 15 (3) ◽  
pp. 172-173 ◽  
Author(s):  
Valdemar Grill ◽  
Bjørn O. Åsvold
Keyword(s):  
Genetic Background ◽  
Clinical Utility ◽  
Autoimmune Diabetes ◽  
Classical Type ◽  
Phenotypic Characteristics ◽  
Latent Autoimmune Diabetes ◽  
The Impact

Latent Autoimmune Diabetes in the Adult, LADA has been investigated less than “classical” type 1 and type 2 diabetes and the criteria for and the relevance of a LADA diagnosis has been challenged. Despite the absence of a genetic background that is exclusive to LADA, this form of diabetes displays phenotypic characteristics that distinguish it from other forms of diabetes. LADA is heterogeneous in terms of the impact of autoimmunity and lifestyle factors, something that poses problems as to therapy and follow-up perhaps particularly in those with marginal positivity. Yet, there appears to be clear clinical utility in classifying individuals as LADA.

scholarly journals ELISA based on peptide antigens reproducing cross-reactive viral epitopes to detect antibodies in Latent Autoimmune Diabetes in Adults vs. Type 1 Diabetes

MethodsX ◽  
2021 ◽  
pp. 101452
Author(s):  
Feliciana Real-Fernández ◽  
Alessandra Gallo ◽  
Francesca Nuti ◽  
Lorenzo Altamore ◽  
Gloria Giovanna Del Vescovo ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Autoimmune Diabetes ◽  
Peptide Antigens ◽  
Latent Autoimmune Diabetes
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