scholarly journals Statin Use Is Prospectively Associated With New-Onset Diabetes After Transplantation in Renal Transplant Recipients

Diabetes Care ◽  
2020 ◽  
Vol 43 (8) ◽  
pp. 1945-1947
Author(s):  
Tamas Szili-Torok ◽  
Stephan J.L. Bakker ◽  
Uwe J.F. Tietge
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Onset Diabetes ◽  
Statin Use ◽  
New Onset

scholarly journals Statin use is prospectively associated with new onset diabetes after transplantation in renal transplant recipients

2020 ◽  
Author(s):  
Tamas Szili-Torok ◽  
Stephan J.L. Bakker ◽  
Uwe J.F. Tietge
Keyword(s):  
Renal Transplant ◽  
Cox Regression ◽  
Rank Test ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Prospective Longitudinal Study ◽  
Onset Diabetes ◽  
Prospective Longitudinal ◽  
Statin Use ◽  
New Onset

Objective: New onset diabetes after transplantation (NODAT) is frequent and worsens graft and patient outcomes in renal transplant recipients (RTR). In the general population statins are diabetogenic. This study investigated whether statins also increase NODAT risk in RTR. <p><br></p><p>Research design and methods: From a prospective longitudinal study of 606 RTR (functioning allograft >1 year, single academic center, follow-up: median 9.6 [6.6-10.2] years) 95 patients using statins were age- and gender-matched to RTR not on statins (all diabetes-free at inclusion) .</p> <p><br></p><p>Results: NODAT incidence was 7.2% (73.3% of these on statins). In Kaplan-Meier (log rank test, p=0.017) and COX regression analyses (HR, 3,86 [1.21-12.27], P=0.022) statins prospectively associated with incident NODAT, even independent of several relevant confounders including immunosuppressive medication and biomarkers of glucose homeostasis. </p> <p><br></p><p>Conclusions: This study demonstrates that statin use is prospectively associated with the development of NODAT in RTR independent of other recognized risk factors. </p>

scholarly journals Statin use is prospectively associated with new onset diabetes after transplantation in renal transplant recipients

2020 ◽  
Author(s):  
Tamas Szili-Torok ◽  
Stephan J.L. Bakker ◽  
Uwe J.F. Tietge
Keyword(s):  
Renal Transplant ◽  
Cox Regression ◽  
Rank Test ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Prospective Longitudinal Study ◽  
Onset Diabetes ◽  
Prospective Longitudinal ◽  
Statin Use ◽  
New Onset

Objective: New onset diabetes after transplantation (NODAT) is frequent and worsens graft and patient outcomes in renal transplant recipients (RTR). In the general population statins are diabetogenic. This study investigated whether statins also increase NODAT risk in RTR. <p><br></p><p>Research design and methods: From a prospective longitudinal study of 606 RTR (functioning allograft >1 year, single academic center, follow-up: median 9.6 [6.6-10.2] years) 95 patients using statins were age- and gender-matched to RTR not on statins (all diabetes-free at inclusion) .</p> <p><br></p><p>Results: NODAT incidence was 7.2% (73.3% of these on statins). In Kaplan-Meier (log rank test, p=0.017) and COX regression analyses (HR, 3,86 [1.21-12.27], P=0.022) statins prospectively associated with incident NODAT, even independent of several relevant confounders including immunosuppressive medication and biomarkers of glucose homeostasis. </p> <p><br></p><p>Conclusions: This study demonstrates that statin use is prospectively associated with the development of NODAT in RTR independent of other recognized risk factors. </p>

scholarly journals Plasma Malondialdehyde and Risk of New-Onset Diabetes after Transplantation in Renal Transplant Recipients: A Prospective Cohort Study

2019 ◽  
Vol 8 (4) ◽  
pp. 453 ◽  
Author(s):  
Manuela Yepes-Calderón ◽  
Camilo Sotomayor ◽  
António Gomes-Neto ◽  
Rijk Gans ◽  
Stefan Berger ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Transplant ◽  
Cox Proportional Hazards ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Dietary Antioxidants ◽  
Onset Diabetes ◽  
Plasma Malondialdehyde ◽  
New Onset

New-onset diabetes after transplantation (NODAT) is a frequent complication in renal transplant recipients (RTR). Although oxidative stress has been associated with diabetes mellitus, data regarding NODAT are limited. We aimed to prospectively investigate the long-term association between the oxidative stress biomarker malondialdehyde (measured by high-performance liquid chromatography) and NODAT in an extensively phenotyped cohort of non-diabetic RTR with a functioning graft ≥1 year. We included 516 RTR (51 ± 13 years-old, 57% male). Median plasma malondialdehyde (MDA) was 2.55 (IQR, 1.92–3.66) µmol/L. During a median follow-up of 5.3 (IQR, 4.6–6.0) years, 56 (11%) RTR developed NODAT. In Cox proportional-hazards regression analyses, MDA was inversely associated with NODAT, independent of immunosuppressive therapy, transplant-specific covariates, lifestyle, inflammation, and metabolism parameters (HR, 0.55; 95% CI, 0.36–0.83 per 1-SD increase; p < 0.01). Dietary antioxidants intake (e.g., vitamin E, α-lipoic acid, and linoleic acid) were effect-modifiers of the association between MDA and NODAT, with particularly strong inverse associations within the subgroup of RTR with relatively higher dietary antioxidants intake. In conclusion, plasma MDA concentration is inversely and independently associated with long-term risk of NODAT in RTR. Our findings support a potential underrecognized role of oxidative stress in post-transplantation glucose homeostasis.

scholarly journals HDL Cholesterol Efflux Predicts Incident New-Onset Diabetes After Transplantation (NODAT) in Renal Transplant Recipients Independent of HDL Cholesterol Levels

Diabetes ◽  
2019 ◽  
Vol 68 (10) ◽  
pp. 1915-1923 ◽  
Author(s):  
Tamas Szili-Torok ◽  
Wijtske Annema ◽  
Josephine L.C. Anderson ◽  
Stephan J.L. Bakker ◽  
Uwe J.F. Tietge
Keyword(s):  
Renal Transplant ◽  
Cholesterol Efflux ◽  
Hdl Cholesterol ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Cholesterol Levels ◽  
Onset Diabetes ◽  
New Onset

scholarly journals High Serum PCSK9 Is Associated With Increased Risk of New-Onset Diabetes After Transplantation in Renal Transplant Recipients

Diabetes Care ◽  
2017 ◽  
Vol 40 (7) ◽  
pp. 894-901 ◽  
Author(s):  
Michele F. Eisenga ◽  
Dorien M. Zelle ◽  
John H. Sloan ◽  
Carlo A.J.M. Gaillard ◽  
Stephan J.L. Bakker ◽  
...  
Keyword(s):  
Renal Transplant ◽  
High Serum ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Onset Diabetes ◽  
Increased Risk ◽  
New Onset
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