scholarly journals HDL Cholesterol Efflux Predicts Incident New-Onset Diabetes After Transplantation (NODAT) in Renal Transplant Recipients Independent of HDL Cholesterol Levels

Diabetes ◽  
2019 ◽  
Vol 68 (10) ◽  
pp. 1915-1923 ◽  
Author(s):  
Tamas Szili-Torok ◽  
Wijtske Annema ◽  
Josephine L.C. Anderson ◽  
Stephan J.L. Bakker ◽  
Uwe J.F. Tietge
Keyword(s):  
Renal Transplant ◽  
Cholesterol Efflux ◽  
Hdl Cholesterol ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Cholesterol Levels ◽  
Onset Diabetes ◽  
New Onset

scholarly journals HDL Cholesterol Efflux Predicts Graft Failure in Renal Transplant Recipients

2015 ◽  
Vol 27 (2) ◽  
pp. 595-603 ◽  
Author(s):  
Wijtske Annema ◽  
Arne Dikkers ◽  
Jan Freark de Boer ◽  
Robin P. F. Dullaart ◽  
Jan-Stephan F. Sanders ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Graft Failure ◽  
Cholesterol Efflux ◽  
Hdl Cholesterol ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals Plasma Malondialdehyde and Risk of New-Onset Diabetes after Transplantation in Renal Transplant Recipients: A Prospective Cohort Study

2019 ◽  
Vol 8 (4) ◽  
pp. 453 ◽  
Author(s):  
Manuela Yepes-Calderón ◽  
Camilo Sotomayor ◽  
António Gomes-Neto ◽  
Rijk Gans ◽  
Stefan Berger ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Transplant ◽  
Cox Proportional Hazards ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Dietary Antioxidants ◽  
Onset Diabetes ◽  
Plasma Malondialdehyde ◽  
New Onset

New-onset diabetes after transplantation (NODAT) is a frequent complication in renal transplant recipients (RTR). Although oxidative stress has been associated with diabetes mellitus, data regarding NODAT are limited. We aimed to prospectively investigate the long-term association between the oxidative stress biomarker malondialdehyde (measured by high-performance liquid chromatography) and NODAT in an extensively phenotyped cohort of non-diabetic RTR with a functioning graft ≥1 year. We included 516 RTR (51 ± 13 years-old, 57% male). Median plasma malondialdehyde (MDA) was 2.55 (IQR, 1.92–3.66) µmol/L. During a median follow-up of 5.3 (IQR, 4.6–6.0) years, 56 (11%) RTR developed NODAT. In Cox proportional-hazards regression analyses, MDA was inversely associated with NODAT, independent of immunosuppressive therapy, transplant-specific covariates, lifestyle, inflammation, and metabolism parameters (HR, 0.55; 95% CI, 0.36–0.83 per 1-SD increase; p < 0.01). Dietary antioxidants intake (e.g., vitamin E, α-lipoic acid, and linoleic acid) were effect-modifiers of the association between MDA and NODAT, with particularly strong inverse associations within the subgroup of RTR with relatively higher dietary antioxidants intake. In conclusion, plasma MDA concentration is inversely and independently associated with long-term risk of NODAT in RTR. Our findings support a potential underrecognized role of oxidative stress in post-transplantation glucose homeostasis.

scholarly journals High Serum PCSK9 Is Associated With Increased Risk of New-Onset Diabetes After Transplantation in Renal Transplant Recipients

Diabetes Care ◽  
2017 ◽  
Vol 40 (7) ◽  
pp. 894-901 ◽  
Author(s):  
Michele F. Eisenga ◽  
Dorien M. Zelle ◽  
John H. Sloan ◽  
Carlo A.J.M. Gaillard ◽  
Stephan J.L. Bakker ◽  
...  
Keyword(s):  
Renal Transplant ◽  
High Serum ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Onset Diabetes ◽  
Increased Risk ◽  
New Onset
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