scholarly journals Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)

Diabetes Care ◽  
2017 ◽  
Vol 40 (11) ◽  
pp. 1514-1521 ◽  
Author(s):  
Andrea L.C. Schneider ◽  
Elizabeth Selvin ◽  
A. Richey Sharrett ◽  
Michael Griswold ◽  
Josef Coresh ◽  
...  
Keyword(s):  
Cerebrovascular Disease ◽  
Brain Volumes ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk

Abstract P123: Prospective Association Between Periodontal Disease And Brain Imaging Markers Of Cerebrovascular And Neurodegenerative Disease: The Atherosclerosis Risk In Communities Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Hamdi S Adam ◽  
Kamakshi Lakshminarayan ◽  
Wendy Wang ◽  
Faye L Norby ◽  
Thomas Mosley ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Brain Aging ◽  
Small Vessel Disease ◽  
Brain Mri ◽  
Standardized Uptake Value ◽  
Tissue Loss ◽  
Total Brain Volume ◽  
Brain Volumes ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk

Background: Periodontal disease (PD) is associated positively with neurocognitive outcomes. Few studies have investigated the relationship between PD and indicators of brain aging and vascular changes. Hypothesis: PD is associated with greater cerebral small vessel disease, lower total and regional brain volumes and elevated β-amyloid (Aβ) deposition. Methods: We included 6,793 participants who received full-mouth periodontal examinations and tooth counts at Visit 4 (1996-1998) of the Atherosclerosis Risk in Communities Study. We used a modified 3-level version of the Periodontal Profile Class to categorize PD based on severity and extent of gingival inflammation and tissue loss. Among participants who attended Visit 5 (2011-2013), n=1,306 received a brain MRI and n=248 received a PET scan. Total brain volume, Alzheimer’s disease signature volume, and presence of microhemorrhages and cerebral infarctions were ascertained via 3T MRI; Aβ deposition was assessed from PET. We regressed brain volumes on baseline PD status using weighted multivariable linear regression. Presence of cerebrovascular microhemorrhages, infarctions, or elevated Aβ (standardized uptake value ratio>1.2) were regressed on PD category using logistic models. We examined the interaction between Apolipoprotein E ε4 ( APOE ) allele possession and PD categories on the Aβ outcome. Results: Prevalence of baseline periodontal disease was 73% (959/1306) and 87% (206/248) among the MRI and PET subgroups, respectively. PD was not associated with volumetric brain measures nor microhemorrhages. PD was inversely associated with the odds of subcortical and lacunar infarctions. PD and Aβ were not associated in main effect or interaction analyses, although there was a notably stronger association among carriers of APOE . Conclusion: PD was not associated with altered brain structure, cerebral microhemorrhages or elevated Aβ deposition. Counter to the hypothesis, PD and complete tooth loss were inversely associated with cerebral infarctions.

scholarly journals Relationship of hearing impairment with MRI brain volumes and cognitive decline in the Atherosclerosis Risk in Communities study

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Jennifer A Deal ◽  
Melinda C Power ◽  
Joshua Betz ◽  
Nicholas S Reed ◽  
Marilyn S Albert ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Hearing Impairment ◽  
Brain Volumes ◽  
Atherosclerosis Risk In Communities ◽  
Mri Brain ◽  
Atherosclerosis Risk ◽  
Relationship Of

scholarly journals Association Between Endogenous Testosterone and Cerebrovascular Disease in the ARIC Study (Atherosclerosis Risk in Communities)

Stroke ◽  
2016 ◽  
Vol 47 (11) ◽  
pp. 2682-2688 ◽  
Author(s):  
Reshmi Srinath ◽  
Rebecca F. Gottesman ◽  
Sherita Hill Golden ◽  
Kathryn A. Carson ◽  
Adrian Dobs
Keyword(s):  
Cerebrovascular Disease ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Aric Study

scholarly journals Association of mid-life serum lipid levels with late-life brain volumes: The atherosclerosis risk in communities neurocognitive study (ARIC NCS)

NeuroImage ◽  
2020 ◽  
Vol 223 ◽  
pp. 117324
Author(s):  
Kasra Moazzami ◽  
Melinda C. Power ◽  
Rebecca Gottesman ◽  
Thomas Mosley ◽  
Pamela L. Lutsey ◽  
...  
Keyword(s):  
Serum Lipid ◽  
Late Life ◽  
Lipid Levels ◽  
Brain Volumes ◽  
Atherosclerosis Risk In Communities ◽  
Serum Lipid Levels ◽  
Atherosclerosis Risk

scholarly journals Associations of Serum Magnesium with Brain Morphology and Subclinical Cerebrovascular Disease: The Atherosclerosis Risk in Communities-Neurocognitive Study

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4496
Author(s):  
Aniqa B. Alam ◽  
DaNashia S. Thomas ◽  
Pamela L. Lutsey ◽  
Srishti Shrestha ◽  
Alvaro Alonso
Keyword(s):  
Cerebrovascular Disease ◽  
Serum Magnesium ◽  
Elevated Serum ◽  
Brain Morphology ◽  
White Matter Hyperintensity ◽  
Atherosclerosis Risk In Communities ◽  
Lower Odds ◽  
Lacunar Infarcts ◽  
Total Brain ◽  
Atherosclerosis Risk

Circulating magnesium has been associated with a lower risk of dementia, but the physiologic effects by which magnesium may prevent neurological insults remain unclear. We studied 1466 individuals (mean age 76.2 ± 5.3, 28.8% black, 60.1% female) free of prevalent stroke, with measured serum magnesium and with available MRI scans obtained in 2011–2013, participating in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS). Cross-sectional differences in frontal, temporal, parietal, and occipital lobe volume, along with deep grey matter, total brain, and white matter hyperintensity volume across serum magnesium (categorized into quintiles and per standard deviation increases) were assessed using multiple linear regression. We also examined associations of magnesium with the prevalence of cortical, subcortical, and lacunar infarcts using multiple logistic regression. After adjusting for demographics, biomarkers, medications, and cardiometabolic risk factors, higher circulating magnesium was associated with greater total brain volume and frontal, temporal, and parietal lobe volumes (volumes 0.14 to 0.19 standard deviations higher comparing Q5 to Q1). Elevated magnesium was also associated with lower odds of subcortical infarcts (OR (95%CI): 0.44 (0.25, 0.77) comparing Q5 to Q1) and lacunar infarcts (OR (95%CI): 0.40 (0.22, 0.71) comparing Q5 to Q1). Elevated serum magnesium was cross-sectionally associated with greater brain volumes and lower odds of subclinical cerebrovascular disease, suggesting beneficial effects on pathways related to neurodegeneration and cerebrovascular damage. Further exploration through prospective analyses is needed to assess increasing circulating magnesium as a potential neuroprotective intervention.

Sign in / Sign up

Export Citation Format

Share Document