scholarly journals Diabetes Prevention in the Real World: Effectiveness of Pragmatic Lifestyle Interventions for the Prevention of Type 2 Diabetes and of the Impact of Adherence to Guideline Recommendations: A Systematic Review and Meta-analysis. Diabetes Care 2014;37:922–933

Diabetes Care ◽  
2014 ◽  
Vol 37 (6) ◽  
pp. 1775-1776 ◽  
Author(s):  
Alison J. Dunkley ◽  
Danielle H. Bodicoat ◽  
Colin J. Greaves ◽  
Claire Russell ◽  
Thomas Yates ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Real World ◽  
Diabetes Care ◽  
Diabetes Prevention ◽  
Meta Analysis ◽  
Lifestyle Interventions ◽  
The Real ◽  
The Impact

scholarly journals Diabetes Prevention in the Real World: Effectiveness of Pragmatic Lifestyle Interventions for the Prevention of Type 2 Diabetes and of the Impact of Adherence to Guideline Recommendations

Diabetes Care ◽  
2014 ◽  
Vol 37 (4) ◽  
pp. 922-933 ◽  
Author(s):  
Alison J. Dunkley ◽  
Danielle H. Bodicoat ◽  
Colin J. Greaves ◽  
Claire Russell ◽  
Thomas Yates ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Real World ◽  
Diabetes Prevention ◽  
Lifestyle Interventions ◽  
The Real ◽  
The Impact

scholarly journals Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis

BMJ ◽  
2007 ◽  
Vol 334 (7588) ◽  
pp. 299 ◽  
Author(s):  
Clare L Gillies ◽  
Keith R Abrams ◽  
Paul C Lambert ◽  
Nicola J Cooper ◽  
Alex J Sutton ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Meta Analysis ◽  
Lifestyle Interventions

scholarly journals Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a Diabetes Care Editors’ Expert Forum

Diabetes Care ◽  
2016 ◽  
Vol 39 (7) ◽  
pp. 1186-1201 ◽  
Author(s):  
William T. Cefalu ◽  
John B. Buse ◽  
Jaakko Tuomilehto ◽  
G. Alexander Fleming ◽  
Ele Ferrannini ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Real World ◽  
Diabetes Care ◽  
Diabetes Prevention ◽  
Type 2 Diabetes Prevention

scholarly journals 1386Ethnic differences in lifestyle interventions for diabetes prevention: a systematic review and meta-analysis

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Mingling Chen ◽  
Gebresilasea Ukke ◽  
Surbhi Sood ◽  
Christie Bennett ◽  
Mahnaz Khomami ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Ethnic Groups ◽  
Diabetes Prevention ◽  
Fasting Glucose ◽  
Meta Analysis ◽  
Diabetes Incidence ◽  
Lifestyle Interventions ◽  
Anthropometric Measures ◽  
Glycemic Outcomes

Abstract Background The risk of type 2 diabetes varies by ethnicity, but ethnic differences in response to lifestyle interventions for diabetes prevention remain unclear. This systematic review and meta-analysis aimed to assess differences in the effects of lifestyle interventions on diabetes incidence, glycemic outcomes and anthropometric measures between ethnic groups. Methods MEDLINE, EMBASE, Pubmed, CINAHL, PsycInfo and EBM Reviews were searched (to June 2020) with no language restriction for randomized and non-randomized controlled trials on lifestyle interventions involving diet and/or physical activity in adults at risk of type 2 diabetes. Ethnicity was categorized into European, South Asian, Other Asian, Middle Eastern, Latin American and African groups based on the World Bank regions. Risk ratios for diabetes incidence and mean differences for glycemic outcomes (fasting glucose, 2-h glucose, HbA1c) and anthropometric measures (weight, BMI, waist circumference) were pooled using random-effects meta-analysis. Results Sixty articles representing 43 studies (18,691 participants) were included in meta-analyses. Overall, lifestyle interventions resulted in significant improvement in diabetes incidence, glycemic outcomes and anthropometric measures compared with controls (all P<0.01). Significant subgroup differences by ethnicity were found for 2-h glucose, weight, BMI and waist circumference (all P<0.05) but not for diabetes incidence, fasting glucose and HbA1c (all P>0.05). Conclusions Lifestyle interventions are similarly effective in reducing diabetes incidence, fasting glucose and HbA1c for all ethnic groups, however, 2-h glucose and anthropometric outcomes should be optimized in certain ethnic groups. Key messages Lifestyle intervention is likely effective in preventing the progression to type 2 diabetes equally across all ethnic groups.

scholarly journals Anti-diabetic agents for prevention of type 2 diabetes mellitus in people with pre-diabetes: a systematic review and network meta-analysis protocol

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e029073 ◽  
Author(s):  
Xianzhe Wang ◽  
Jiabin Liu ◽  
Lijin Huang ◽  
Hai Zeng ◽  
Guoxin He ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetes Prevention ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Glucose Lowering ◽  
Increased Risk

IntroductionType 2 diabetes mellitus (T2DM) is a substantial health problem worldwide. Pre-diabetic state is associated with increased risk for the development of diabetes. There are various pharmacological therapies with glucose-lowering activity for diabetes prevention. Of those, most are being compared with placebo instead of active agents. The relative effects and safety of different glucose-lowering drugs still remain uncertain. To address this gap, we will conduct a systematic review and network meta-analysis (NMA) to evaluate comparative efficacy and safety of glucose-lowering agents for T2DM prevention in patients with pre-diabetes.Methods and analysisPubMed, the Cochrane library and Embase will be searched from inception to December 2019 for relevant randomised controlled trials (RCTs) that examined anti-diabetic drugs for diabetes prevention in patients with pre-diabetes. Two reviewers working independently will screen titles, abstracts and full papers. Data extraction will also be completed by two independent authors. The primary outcome will be the incidence of T2DM in patients with pre-diabetes at baseline. Secondary outcomes will include the achievement of normoglycaemia, all-cause mortality, cardiovascular mortality and hypoglycaemic event. Pairwise meta-analysis and NMA will be conducted for each outcome using a frequentist random-effects model. Additionally, subgroup analyses will also be performed. The comparison-adjusted funnel plot will be used to assess publication bias. The overall quality of evidence will be rated with the Grading of Recommendations Assessment, Development and Evaluation framework. Data analysis will be conducted using Stata V.14.0.Ethics and disseminationEthics approval is not required. We plan to submit the results of this study to a peer-review journal.PROSPERO registration numberCRD42019119157.

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