scholarly journals Effect of 8 Weeks of Overfeeding on Ectopic Fat Deposition and Insulin Sensitivity: Testing the “Adipose Tissue Expandability” Hypothesis

Diabetes Care ◽  
2014 ◽  
Vol 37 (10) ◽  
pp. 2789-2797 ◽  
Author(s):  
Darcy L. Johannsen ◽  
Yourka Tchoukalova ◽  
Charmaine S. Tam ◽  
Jeffrey D. Covington ◽  
Wenting Xie ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Fat Deposition ◽  
Ectopic Fat ◽  
Sensitivity Testing ◽  
Ectopic Fat Deposition ◽  
Adipose Tissue Expandability

scholarly journals Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance

Cell Reports ◽  
2020 ◽  
Vol 33 (2) ◽  
pp. 108265 ◽  
Author(s):  
Tomoaki Inazumi ◽  
Kiyotaka Yamada ◽  
Naritoshi Shirata ◽  
Hiroyasu Sato ◽  
Yoshitaka Taketomi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Prostaglandin E2 ◽  
Fat Deposition ◽  
Ectopic Fat ◽  
Ectopic Fat Deposition

scholarly journals Unsupervised Exercise Training Was Not Found to Improve the Metabolic Health or Phenotype over a 6-Month Dietary Intervention: A Randomised Controlled Trial with an Embedded Economic Analysis

2021 ◽  
Vol 18 (15) ◽  
pp. 8004
Author(s):  
Wendy Hens ◽  
Dirk Vissers ◽  
Nick Verhaeghe ◽  
Jan Gielen ◽  
Luc Van Gaal ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Exercise Training ◽  
Economic Analysis ◽  
Controlled Trial ◽  
Metabolic Health ◽  
Overweight And Obesity ◽  
Fat Deposition ◽  
Hypocaloric Diet ◽  
Ectopic Fat ◽  
Ectopic Fat Deposition

Ectopic fat leads to metabolic health problems. This research aimed to assess the effectiveness of a hypocaloric diet intervention together with an unsupervised exercise training program in comparison with a hypocaloric diet alone to reduce ectopic fat deposition. Sixty-one premenopausal women with overweight or obesity participated in this controlled trial and were each randomised into either a usual care group (hypocaloric diet) or intervention group (hypocaloric diet + unsupervised exercise training). Ectopic fat deposition, metabolic parameters, incremental costs from a societal perspective and incremental quality-adjusted life years (QALYs) were assessed before, during and after the six-month intervention period. In the total sample, there was a significant decrease in visceral adipose tissue (VAT: −18.88 cm², 95% CI −11.82 to −25.95), subcutaneous abdominal adipose tissue (SAT: −46.74 cm², 95% CI −29.76 to −63.18), epicardial fat (ECF: −14.50 cm³, 95% CI −10.9 to −18.98) and intrahepatic lipid content (IHL: −3.53%, 95% CI −1.72 to −5.32). Consequently, an “adapted” economic analysis revealed a non-significant decrease in costs and an increase in QALYs after the intervention. No significant differences were found between groups. A multidisciplinary lifestyle approach seems successful in reducing ectopic fat deposition and improving the metabolic risk profile in women with overweight and obesity. The addition of unsupervised exercise training did not further improve the metabolic health or phenotype over the six months.

scholarly journals Duodenal adipose tissue is associated with obesity in baboons (Papio sp): a novel site of ectopic fat deposition in non-human primates

2019 ◽  
Vol 56 (2) ◽  
pp. 227-236 ◽  
Author(s):  
Paul B. Higgins ◽  
Franco Folli ◽  
Marcia C. R. Andrade ◽  
Jaydee Foster ◽  
Vicki Mattern ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fat Deposition ◽  
Ectopic Fat ◽  
Ectopic Fat Deposition

scholarly journals Differences in the link between insulin sensitivity and ectopic fat in men of Black African and White European ethnicity

2020 ◽  
Vol 182 (1) ◽  
pp. 91-101 ◽  
Author(s):  
Oluwatoyosi Bello ◽  
Meera Ladwa ◽  
Olah Hakim ◽  
Chinmay Marathe ◽  
Fariba Shojaee-Moradie ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Normal Glucose Tolerance ◽  
Whole Body ◽  
Ectopic Fat ◽  
Black African ◽  
Hepatic Insulin Sensitivity ◽  
Normal Glucose ◽  
Skeletal Muscle Insulin Sensitivity ◽  
Ectopic Fat Deposition

Objectives In men of black west African (BAM) and white European (WEM) ethnicity, we aimed to (1) compare adipose tissue, peripheral and hepatic insulin sensitivity and (2) investigate associations between ectopic fat and insulin sensitivity by ethnicity. Design and methods In overweight BAM (n = 21) and WEM (n = 23) with normal glucose tolerance, we performed a two-step hyperinsulinaemic–euglycaemic clamp with infusion of [6,6 2H2]-glucose and [2H5]-glycerol to measure whole body, peripheral, hepatic and adipose tissue insulin sensitivity (lipolysis). Visceral adipose tissue (VAT), intrahepatic lipids (IHL) and intramyocellular (IMCL) lipids were measured using MRI and spectroscopy. Associations between insulin sensitivity and ectopic fat were assessed using Pearson’s correlation coefficient by ethnicity and regression analysis. Results There were no ethnic differences in whole body or tissue-specific insulin sensitivity (all P  > 0.05). Suppression of lipolysis was inversely associated with VAT and IHL in WEM but not BAM (VAT: WEM r = −0.68, P < 0.01; BAM r = 0.07, P = 0.79. IHL: WEM r = −0.52, P = 0.01; BAM r = −0.12, P = 0.63). IMCL was inversely associated with skeletal muscle insulin sensitivity in WEM but not BAM (WEM r = −0.56, P < 0.01; BAM r = −0.09, P = 0.75) and IHL was inversely associated with hepatic insulin sensitivity in WEM but not BAM (WEM r = −0.53, P = 0.02; BAM r = −0.13, P = 0.62). Conclusions Ectopic fat deposition may play a lesser role in reducing insulin sensitivity in men of black African ethnicity and may not be driven by lipolysis. Resistance to storing VAT, IHL and IMCL may enable men of black African ethnicity to maintain comparable insulin sensitivity to white Europeans.

scholarly journals Roles of Chronic Low-Grade Inflammation in the Development of Ectopic Fat Deposition

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Lulu Liu ◽  
Mei Mei ◽  
Shumin Yang ◽  
Qifu Li
Keyword(s):  
Adipose Tissue ◽  
Fat Distribution ◽  
Underlying Mechanism ◽  
Fat Deposition ◽  
Low Grade ◽  
Ectopic Fat ◽  
Metabolic Complications ◽  
Novel Therapeutic Strategies ◽  
Ectopic Fat Deposition ◽  
Low Grade Inflammation

Pattern of fat distribution is a major determinant for metabolic homeostasis. As a depot of energy, the storage of triglycerides in adipose tissue contributes to the normal fat distribution. Decreased capacity of fat storage in adipose tissue may result in ectopic fat deposition in nonadipose tissues such as liver, pancreas, and kidney. As a critical biomarker of metabolic complications, chronic low-grade inflammation may have the ability to affect the process of lipid accumulation and further lead to the disorder of fat distribution. In this review, we have collected the evidence linking inflammation with ectopic fat deposition to get a better understanding of the underlying mechanism, which may provide us with novel therapeutic strategies for metabolic disorders.

Imaging ectopic fat deposition incaenorhabditis elegansmuscles using nonlinear microscopy

2015 ◽  
Vol 78 (6) ◽  
pp. 523-528 ◽  
Author(s):  
Meropi Mari ◽  
George Filippidis ◽  
Konstantinos Palikaras ◽  
Barbara Petanidou ◽  
Costas Fotakis ◽  
...  
Keyword(s):  
Fat Deposition ◽  
Ectopic Fat ◽  
Nonlinear Microscopy ◽  
Ectopic Fat Deposition
Sign in / Sign up

Export Citation Format

Share Document