scholarly journals Moderate-Intensity Physical Activity Ameliorates the Breast Cancer Risk in Diabetic Women

Diabetes Care ◽  
2012 ◽  
Vol 35 (12) ◽  
pp. 2500-2502 ◽  
Author(s):  
G. Torres-Mejia ◽  
A. Angeles-Llerenas ◽  
C. Ortega-Olvera ◽  
E. Lazcano-Ponce ◽  
E. Ziv ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Moderate Intensity ◽  
Moderate Intensity Physical Activity ◽  
Intensity Physical Activity

A case–control study of lifetime light intensity physical activity and breast cancer risk

2013 ◽  
Vol 25 (1) ◽  
pp. 133-140 ◽  
Author(s):  
Lindsay C. Kobayashi ◽  
Ian Janssen ◽  
Harriet Richardson ◽  
Agnes S. Lai ◽  
John J. Spinelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Breast Cancer Risk ◽  
Light Intensity ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Intensity Physical Activity ◽  
Control Study

scholarly journals Influence of Pre- and Postdiagnosis Physical Activity on Mortality in Breast Cancer Survivors: The Health, Eating, Activity, and Lifestyle Study

2008 ◽  
Vol 26 (24) ◽  
pp. 3958-3964 ◽  
Author(s):  
Melinda L. Irwin ◽  
Ashley Wilder Smith ◽  
Anne McTiernan ◽  
Rachel Ballard-Barbash ◽  
Kathy Cronin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Breast Cancer Survivors ◽  
Moderate Intensity ◽  
Moderate Intensity Physical Activity ◽  
Risk Of Death ◽  
Hazard Ratios ◽  
Before And After ◽  
Intensity Physical Activity ◽  
Health Eating

Purpose To investigate the association between pre- and postdiagnosis physical activity (as well as change in prediagnosis to postdiagnosis physical activity) and mortality among women with breast cancer. Patients and Methods This was a prospective observational study of 933 women enrolled onto the Health, Eating, Activity, and Lifestyle Study who were diagnosed with local or regional breast cancer between 1995 and 1998 and observed until death or September 2004, whichever came first. The primary outcomes measured were total deaths and breast cancer deaths. The primary exposures were physical activity in the year before and 2 years after diagnosis and the pre- to postdiagnosis change in physical activity. Results Compared with inactive women, the multivariable hazard ratios (HRs) for total deaths for women expending at least 9 metabolic equivalent hours per week (approximately 2 to 3 h/wk of brisk walking) were 0.69 (95% CI, 0.45 to 1.06; P = .045) for those active in the year before diagnosis and 0.33 (95% CI, 0.15 to 0.73; P = .046) for those active 2 years after diagnosis. Compared with women who were inactive both before and after diagnosis, women who increased physical activity after diagnosis had a 45% lower risk of death (HR = 0.55; 95% CI, 0.22 to 1.38), and women who decreased physical activity after diagnosis had a four-fold greater risk of death (HR = 3.95; 95% CI, 1.45 to 10.50). Conclusion Moderate-intensity physical activity after a diagnosis of breast cancer may improve prognosis.

Randomized Trial of a Telephone-Based Weight Loss Intervention in Postmenopausal Women With Breast Cancer Receiving Letrozole: The LISA Trial

2014 ◽  
Vol 32 (21) ◽  
pp. 2231-2239 ◽  
Author(s):  
Pamela J. Goodwin ◽  
Roanne J. Segal ◽  
Michael Vallis ◽  
Jennifer A. Ligibel ◽  
Gregory R. Pond ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Weight Loss ◽  
Randomized Trial ◽  
Disease Free Survival ◽  
Self Report ◽  
Moderate Intensity ◽  
Moderate Intensity Physical Activity ◽  
Intensity Physical Activity ◽  
Poor Outcomes

Purpose Obesity is associated with poor outcomes in women with operable breast cancer. Lifestyle interventions (LIs) that help women reduce their weight may improve outcomes. Patients and Methods We conducted a multicenter randomized trial comparing mail-based delivery of general health information alone or combined with a 24-month standardized, telephone-based LI that included diet (500 to 1,000 kcal per day deficit) and physical activity (150 to 200 minutes of moderate-intensity physical activity per week) goals to achieve weight loss (up to 10%). Women receiving adjuvant letrozole for T1-3N0-3M0 breast cancer with a body mass index (BMI) ≥ 24 kg/m2 were eligible. Weight was measured in the clinic, and self-report physical activity, quality-of-life (QOL), and diet questionnaires were completed. The primary outcome was disease-free survival. Accrual was terminated at 338 of 2,150 planned patients because of loss of funding. Results Mean weight loss was significantly (P < .001) greater in the LI arm versus the comparison arm (4.3 v 0.6 kg or 5.3% v 0.7% at 6 months and 3.1 v 0.3 kg or 3.6% v 0.4% at 24 months) and occurred consistently across strata (BMI 24 to < 30 v ≥ 30 kg/m2; prior v no prior adjuvant chemotherapy). Weight loss was greatest in those with higher baseline levels of moderate-intensity physical activity or improvement in QOL. Hospitalization rates and medical events were similar. Conclusion A telephone-based LI led to significant weight loss that was still evident at 24 months, without adverse effects on QOL, hospitalizations, or medical events. Adequately powered randomized trials with cancer end points are needed.

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