scholarly journals Genetic Risk Score Constructed Using 14 Susceptibility Alleles for Type 2 Diabetes Is Associated With the Early Onset of Diabetes and May Predict the Future Requirement of Insulin Injections Among Japanese Individuals

Diabetes Care ◽  
2012 ◽  
Vol 35 (8) ◽  
pp. 1763-1770 ◽  
Author(s):  
M. Iwata ◽  
S. Maeda ◽  
Y. Kamura ◽  
A. Takano ◽  
H. Kato ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Score ◽  
Genetic Risk ◽  
Early Onset ◽  
Genetic Risk Score ◽  
The Future ◽  
Onset Of Diabetes ◽  
Future Requirement

Genetic variants associated with the early onset of type 2 diabetes in the Hungarian population

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
N Werissa ◽  
P Pikó ◽  
S Fiatal ◽  
J Sándor ◽  
R Ádány
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Correlation Analysis ◽  
Risk Score ◽  
Genetic Risk ◽  
Early Onset ◽  
Genetic Risk Score ◽  
Age At Onset ◽  
Hungarian Population

Abstract Background It is generally accepted that early detection of type 2 diabetes mellitus (T2DM) is important to prevent the development of complications and comorbidities, as well as premature death. In addition to the environmental risk factors, genetic factors may also contribute to the development of T2DM. The aim of our study is to identify single nucleotide polymorphisms (SNPs) which have an effect on the early onset of T2DM in the Hungarian population. Methods This study included 891 T2DM patients (438 males and 453 females). The onset of T2DM varied between 25 and 90 years of age. Pearson correlation analysis was carried out for 16 SNPs to define how they are associated with the patient's age at onset of T2DM and genetic risk score was calculated for each patient by computation of alleles identified as risk ones. Linear regression analyses were used to estimate the effect of GRS on the early onset of T2DM independently of conventional risk factors (sex, BMI and TG/HDL-C ratio). Results Six SNPs (rs111875 in HHEX gene, rs560887 in G6PC2 gene, rs11071657 in the C2CD4B gene, rs5219 in KCNJ11 gene, rs10830963 in MTNR1B gene and rs11671664 in GIPR gene) were identified as risk polymorphism in the correlation analysis and GRS was calculated by defining their number/subject. The GRS showed significant association (β=-0.486, p = 0.008) with younger age at onset of T2DM. The correlation of GRS with the risk of earlier onset of T2DM was significant in the male population (β= -0.581, p = 0.024) and close to significant in female one (β= -0.471, p = 0.068). Conclusions Our findings indicate a considerable genetic predisposition for early onset of T2DM, which is mainly attributed to the cumulative effect of 6 SNPs presently known to be susceptible alleles. This set of SNPs and the genetic risk score calculated can be used for estimating the risk of earlier onset of T2DM on individual and population levels. Key messages SNPs were identified to play a role in the early onset of T2DM in the Hungarian population. The genetic risk score calculated by computation of susceptible alleles can be used for risk estimation of early onset of T2DM.

Genetic Risk Score for Type 2 Diabetes and Traits Related to Glucose-Insulin Homeostasis in Youth: The Exploring Perinatal Outcomes Among Children (EPOCH) Study

Diabetes Care ◽  
2021 ◽  
pp. dc210464
Author(s):  
Maggie A. Stanislawski ◽  
Elizabeth Litkowski ◽  
Sridharan Raghavan ◽  
Kylie K. Harrall ◽  
Jessica Shaw ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Perinatal Outcomes ◽  
Insulin Homeostasis

Prediction of type 2 diabetes in women with a history of gestational diabetes using a genetic risk score

Diabetologia ◽  
2013 ◽  
Vol 56 (12) ◽  
pp. 2556-2563 ◽  
Author(s):  
Soo Heon Kwak ◽  
Sung Hee Choi ◽  
Kyunga Kim ◽  
Hye Seung Jung ◽  
Young Min Cho ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gestational Diabetes ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
History Of

scholarly journals Association of a 62 Variants Type 2 Diabetes Genetic Risk Score With Markers of Subclinical Atherosclerosis

2015 ◽  
Vol 8 (3) ◽  
pp. 507-515 ◽  
Author(s):  
Marco Dauriz ◽  
Bianca C. Porneala ◽  
Xiuqing Guo ◽  
Lawrence F. Bielak ◽  
Patricia A. Peyser ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Score ◽  
Genetic Risk ◽  
Subclinical Atherosclerosis ◽  
Genetic Risk Score

scholarly journals Genetic Risk Score of 46 Type 2 Diabetes Risk Variants Associates With Changes in Plasma Glucose and Estimates of Pancreatic  -Cell Function Over 5 Years of Follow-Up

Diabetes ◽  
2013 ◽  
Vol 62 (10) ◽  
pp. 3610-3617 ◽  
Author(s):  
E. A. Andersson ◽  
K. H. Allin ◽  
C. H. Sandholt ◽  
A. Borglykke ◽  
C. J. Lau ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Score ◽  
Plasma Glucose ◽  
Genetic Risk ◽  
Cell Function ◽  
Genetic Risk Score ◽  
Pancreatic Cell ◽  
Risk Variants

scholarly journals Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score

2016 ◽  
Vol 94 ◽  
pp. 263-271 ◽  
Author(s):  
Ikenna C. Eze ◽  
Medea Imboden ◽  
Ashish Kumar ◽  
Arnold von Eckardstein ◽  
Daiana Stolz ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Air Pollution ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score

scholarly journals The efficacy of family history, genetic risk score and physical activity in distinguishing type 2 diabetes prevalence

2019 ◽  
Author(s):  
Lukasz Szczerbinski ◽  
Joanna Goscik ◽  
Witold Bauer ◽  
Natalia Wawrusiewicz-Kurylonek ◽  
Magdalena Paczkowska-Abdulsalam ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 2 Diabetes ◽  
Family History ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Diabetes Prevalence

P6188Predicting type 2 diabetes mellitus: combining a genetic risk score with traditional risk factors

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
J Ponte Monteiro ◽  
M I Mendonca ◽  
A Pereira ◽  
A C Sousa ◽  
R Rodrigues ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Traditional Risk Factors

A Comprehensive Type 1 Diabetes Genetic Risk Score Is Associated with Type 2 Diabetes in the Framingham Heart Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1715-P
Author(s):  
SHYLAJA SRINIVASAN ◽  
AARON LEONG ◽  
MIRIAM UDLER ◽  
BIANCA C. PORNEALA ◽  
JAMES B. MEIGS ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Risk Score ◽  
Genetic Risk ◽  
Framingham Heart Study ◽  
Genetic Risk Score ◽  
Heart Study
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