scholarly journals RE: “ADDITIVE AND MULTIPLICATIVE INTERACTIONS BETWEEN GENETIC RISK SCORE AND FAMILY HISTORY AND LIFESTYLE IN RELATION TO RISK OF TYPE 2 DIABETES”

2020 ◽  
Vol 189 (5) ◽  
pp. 483-483
Keyword(s):  
Type 2 Diabetes ◽  
Family History ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score

scholarly journals The efficacy of family history, genetic risk score and physical activity in distinguishing type 2 diabetes prevalence

2019 ◽  
Author(s):  
Lukasz Szczerbinski ◽  
Joanna Goscik ◽  
Witold Bauer ◽  
Natalia Wawrusiewicz-Kurylonek ◽  
Magdalena Paczkowska-Abdulsalam ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 2 Diabetes ◽  
Family History ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Diabetes Prevalence

scholarly journals Additive and Multiplicative Interactions Between Genetic Risk Score and Family History and Lifestyle in Relation to Risk of Type 2 Diabetes

2019 ◽  
Vol 189 (5) ◽  
pp. 445-460 ◽  
Author(s):  
Ming Ding ◽  
Shafqat Ahmad ◽  
Lu Qi ◽  
Yang Hu ◽  
Shilpa N Bhupathiraju ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Family History ◽  
Risk Score ◽  
Genetic Risk ◽  
Healthy Lifestyle ◽  
Genetic Risk Score ◽  
European Ancestry ◽  
Health Study ◽  
Public Health Implication

Abstract We examined interactions between lifestyle factors and genetic risk of type 2 diabetes (T2D-GR), captured by genetic risk score (GRS) and family history (FH). Our initial study cohort included 20,524 European-ancestry participants, of whom 1,897 developed incident T2D, in the Nurses’ Health Study (1984–2016), Nurses’ Health Study II (1989–2016), and Health Professionals Follow-up Study (1986–2016). The analyses were replicated in 19,183 European-ancestry controls and 2,850 incident T2D cases in the Women’s Genome Health Study (1992–2016). We defined 2 categories of T2D-GR: high GRS (upper one-third) with FH and low GRS or without FH. Compared with participants with the healthiest lifestyle and low T2D-GR, the relative risk of T2D for participants with the healthiest lifestyle and high T2D-GR was 2.24 (95% confidence interval (CI): 1.76, 2.86); for participants with the least healthy lifestyle and low T2D-GR, it was 4.05 (95% CI: 3.56, 4.62); and for participants with the least healthy lifestyle and high T2D-GR, it was 8.72 (95% CI: 7.46, 10.19). We found a significant departure from an additive risk difference model in both the initial and replication cohorts, suggesting that adherence to a healthy lifestyle could lead to greater absolute risk reduction among those with high T2D-GR. The public health implication is that a healthy lifestyle is important for diabetes prevention, especially for individuals with high GRS and FH of T2D.

Genetic Risk Score for Type 2 Diabetes and Traits Related to Glucose-Insulin Homeostasis in Youth: The Exploring Perinatal Outcomes Among Children (EPOCH) Study

Diabetes Care ◽  
2021 ◽  
pp. dc210464
Author(s):  
Maggie A. Stanislawski ◽  
Elizabeth Litkowski ◽  
Sridharan Raghavan ◽  
Kylie K. Harrall ◽  
Jessica Shaw ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Perinatal Outcomes ◽  
Insulin Homeostasis

Prediction of type 2 diabetes in women with a history of gestational diabetes using a genetic risk score

Diabetologia ◽  
2013 ◽  
Vol 56 (12) ◽  
pp. 2556-2563 ◽  
Author(s):  
Soo Heon Kwak ◽  
Sung Hee Choi ◽  
Kyunga Kim ◽  
Hye Seung Jung ◽  
Young Min Cho ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gestational Diabetes ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
History Of

scholarly journals Association of a 62 Variants Type 2 Diabetes Genetic Risk Score With Markers of Subclinical Atherosclerosis

2015 ◽  
Vol 8 (3) ◽  
pp. 507-515 ◽  
Author(s):  
Marco Dauriz ◽  
Bianca C. Porneala ◽  
Xiuqing Guo ◽  
Lawrence F. Bielak ◽  
Patricia A. Peyser ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Score ◽  
Genetic Risk ◽  
Subclinical Atherosclerosis ◽  
Genetic Risk Score

scholarly journals Genetic Risk Score of 46 Type 2 Diabetes Risk Variants Associates With Changes in Plasma Glucose and Estimates of Pancreatic  -Cell Function Over 5 Years of Follow-Up

Diabetes ◽  
2013 ◽  
Vol 62 (10) ◽  
pp. 3610-3617 ◽  
Author(s):  
E. A. Andersson ◽  
K. H. Allin ◽  
C. H. Sandholt ◽  
A. Borglykke ◽  
C. J. Lau ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Score ◽  
Plasma Glucose ◽  
Genetic Risk ◽  
Cell Function ◽  
Genetic Risk Score ◽  
Pancreatic Cell ◽  
Risk Variants

scholarly journals Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score

2016 ◽  
Vol 94 ◽  
pp. 263-271 ◽  
Author(s):  
Ikenna C. Eze ◽  
Medea Imboden ◽  
Ashish Kumar ◽  
Arnold von Eckardstein ◽  
Daiana Stolz ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Air Pollution ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score

P6188Predicting type 2 diabetes mellitus: combining a genetic risk score with traditional risk factors

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
J Ponte Monteiro ◽  
M I Mendonca ◽  
A Pereira ◽  
A C Sousa ◽  
R Rodrigues ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Traditional Risk Factors

A Comprehensive Type 1 Diabetes Genetic Risk Score Is Associated with Type 2 Diabetes in the Framingham Heart Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1715-P
Author(s):  
SHYLAJA SRINIVASAN ◽  
AARON LEONG ◽  
MIRIAM UDLER ◽  
BIANCA C. PORNEALA ◽  
JAMES B. MEIGS ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Risk Score ◽  
Genetic Risk ◽  
Framingham Heart Study ◽  
Genetic Risk Score ◽  
Heart Study
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