scholarly journals Circulating 25-Hydroxyvitamin D Concentrations Are Correlated With Cardiometabolic Risk Among American Black and White Adolescents Living in a Year-Round Sunny Climate

Diabetes Care ◽  
2012 ◽  
Vol 35 (5) ◽  
pp. 1133-1138 ◽  
Author(s):  
S. Parikh ◽  
D.-h. Guo ◽  
N. K. Pollock ◽  
K. Petty ◽  
J. Bhagatwala ◽  
...  
1990 ◽  
Vol 11 (2) ◽  
pp. 128-132 ◽  
Author(s):  
Sherahe Brown Fitzpatrick ◽  
Cindy Fujii ◽  
G.Paul Shragg ◽  
Lynn Rice ◽  
Maria Morgan ◽  
...  

2018 ◽  
Vol 22 (3) ◽  
pp. 85-92 ◽  
Author(s):  
Candice L. Foster ◽  
Edward F. Harris

Tooth crown shapes differ among human groups because the sizes and shapes of the constituent crown components differ. It was of interest to us whether there is patterned variation in crown indexes between sexes or among ethnic groups. The crown index—buccolingual width as a function of mesiodistal length—was analyzed here in terms of sex and race differences in a cohort of American black and white adolescents (n = 324) from the U.S. Mid-South. The mandibular canine is distinctive in exhibiting significant sexual dimorphism in crown shape, with females being broader in terms of mesiodistal length. Prior literature reports the crown indexes of several tooth types to be dimorphic, which does not occur here, showing that the extent of sexual dimorphism differs among groups. In contrast, we found that multiple crown indexes differ significantly between the samples of blacks and whites, with the largest differences in UC, UP1, and LM2. Of note, nature of the differences are tooth-specific, suggesting that divergence among groups at this microevolutionary level has shifted crown shapes along distinctive (rather than parallel) pathways. The optimum subset of crown indexes correctly allocates 67% of the specimens as to race; this percentage is not much better than chance, suggesting that crown indexes are of little forensic usefulness in discriminating among contemporary humans.


1978 ◽  
Vol 26 (1) ◽  
pp. 86-96 ◽  
Author(s):  
Roberta G. Simmons ◽  
Leslie Brown ◽  
Diane Mitsch Bush ◽  
Dale A. Blyth

2019 ◽  
Vol 129 (01) ◽  
pp. 7-13
Author(s):  
Robert Krysiak ◽  
Witold Szkróbka ◽  
Bogusław Okopień

Abstract Background Macroprolactinemia is a condition associated with the presence of large amounts of high molecular weight complexes of prolactin. Despite high prevalence, clinical significance of macroprolactin remains poorly understood. Objective The aim of this study was to assess cardiometabolic risk in men with isolated macroprolactinemia. Methods The study population included 11 men with isolated macroprolactinemia, 14 subjects with monomeric hyperprolactinemia and 14 men with prolactin levels within the reference range. Glucose homeostasis markers, plasma lipids, as well as plasma levels of uric acid, high-sensitivity C-reactive protein (hsCRP), fibrinogen, homocysteine and 25-hydroxyvitamin D were determined in all included patients. Results Compared to healthy counterparts, men with isolated macroprolactinemia had higher levels of 2-h postchallenge glucose, hsCRP and fibrinogen, lower levels of 25-hydroxyvitamin D and reduced insulin sensitivity. Patients with monomeric hyperprolactinemia were characterized by increased plasma levels of 2-h postchallenge glucose, triglycerides, uric acid, hsCRP, fibrinogen and homocysteine, reduced insulin sensitivity and decreased plasma concentrations of HDL cholesterol and 25-hydroxyvitamin D. Subjects with isolated macroprolactinemia differed from patients with monomeric hyperprolactinemia in postchallenge plasma glucose, insulin sensitivity, uric acid, hsCRP, fibrinogen, homocysteine and 25-hydroxyvitamin D. In men with monomeric hyperprolactinemia, uric acid, hsCRP, fibrinogen, homocysteine and 25-hydroxyvitamin D, while in men with elevated levels of macroprolactin, uric acid, hsCRP, fibrinogen and 25-hydroxyvitamin D correlated with a content of monomeric prolactin or macroprolactin, respectively, as well as with a degree of insulin sensitivity. Conclusions The obtained results suggest that macroprolactinemia may increase cardiometabolic risk but to a lesser extent than monomeric hyperprolactinemia.


Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1938 ◽  
Author(s):  
Li Chen ◽  
Haidong Zhu ◽  
Gregory A. Harshfield ◽  
Frank A. Treiber ◽  
Jennifer S. Pollock ◽  
...  

We aimed to test the hypothesis that serum 25-hydroxyvitamin D3 (25(OH)D) concentration is associated with mental health and life stress measures in young adults and investigate gender and racial disparities in these associations. This study comprised 327 black and white participants. Depression, trait anxiety, perceived stress, and hostility were measured by the following validated instruments: Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), Perceived Stress Scale (PSS), and Cook–Medley Hostility Scale (CMHS). Linear regression was used to estimate correlations between serum 25(OH)D concentration and mental health measurements in the total population and in subgroups stratified by gender and race. In this sample (28.2 ± 3.1 years, 52% female, 53% black), serum 25(OH)D concentration was negatively related to BDI, STAI, PSS, total CMHS score, and the majority of CMHS subscale scores (p-values < 0.05). Stratified by gender, most of these associations remained significant only in women (p-values < 0.05). Stratified by race, higher 25(OH)D concentrations in white participants were significantly related to lower BDI, STAI, PSS, and CMHS-cynicism subscales (p-values < 0.05); 25(OH)D concentrations in the black participants were only inversely associated with CMHS and most CMHS subscales (p-values < 0.05) but not with BDI, STAI, and PSS. We present novel findings of consistent inverse relationships between serum 25(OH)D concentration and various measures of mental health and life stress. Long-term interventional studies are warranted in order to investigate the roles of vitamin D supplementation in the prevention and mitigation of depression, anxiety, and psychological stress in young adults.


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