scholarly journals Dietary Patterns and Incident Type 2 Diabetes in Chinese Men and Women: The Singapore Chinese Health Study

Diabetes Care ◽  
2011 ◽  
Vol 34 (4) ◽  
pp. 880-885 ◽  
Author(s):  
A. O. Odegaard ◽  
W.-P. Koh ◽  
L. M. Butler ◽  
S. Duval ◽  
M. D. Gross ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Patterns ◽  
Health Study ◽  
Men And Women ◽  
Chinese Men ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Singapore Chinese

scholarly journals Omega-3 fatty acids and incident type 2 diabetes: the Singapore Chinese Health Study

2011 ◽  
Vol 94 (2) ◽  
pp. 520-526 ◽  
Author(s):  
Diana P Brostow ◽  
Andrew O Odegaard ◽  
Woon-Puay Koh ◽  
Sue Duval ◽  
Myron D Gross ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Health Study ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Singapore Chinese

scholarly journals Glycated Hemoglobin and Incident Type 2 Diabetes in Singaporean Chinese Adults: The Singapore Chinese Health Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119884 ◽  
Author(s):  
Michael P. Bancks ◽  
Andrew O. Odegaard ◽  
Woon-Puay Koh ◽  
Jian-Min Yuan ◽  
Myron D. Gross ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycated Hemoglobin ◽  
Health Study ◽  
Chinese Adults ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Singapore Chinese

scholarly journals Coffee, tea, and incident type 2 diabetes: the Singapore Chinese Health Study

2008 ◽  
Vol 88 (4) ◽  
pp. 979-985 ◽  
Author(s):  
Andrew O Odegaard ◽  
Mark A Pereira ◽  
Woon-Puay Koh ◽  
Kazuko Arakawa ◽  
Hin-Peng Lee ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Health Study ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Singapore Chinese

scholarly journals Deciphering the Plasma Proteome of Type 2 Diabetes

2020 ◽  
Author(s):  
Ada Admin ◽  
Mohamed A. Elhadad ◽  
Christian Jonasson ◽  
Cornelia Huth ◽  
Rory Wilson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Growth Hormone Receptor ◽  
Smoking Status ◽  
Underlying Disease ◽  
Sex Hormone Binding Globulin ◽  
Health Study ◽  
Study Cohort ◽  
Incident Type ◽  
Incident Type 2 Diabetes

With an estimated prevalence of 463 million affected, type 2 diabetes represents a major challenge to health care systems worldwide. Analyzing the plasma proteomes of individuals with type 2 diabetes may illuminate hitherto unknown functional mechanisms underlying disease pathology. We assessed the associations between type 2 diabetes and >1000 plasma proteins in the KORA (Cooperative health research in the Region of Augsburg) F4 cohort (n=993, 110 cases), with subsequent replication in the HUNT3 (Third wave of the Nord-Trøndelag Health Study) cohort (n=940, 149 cases). We computed logistic regression models adjusted for age, sex, BMI, smoking status and hypertension. Additionally, we investigated associations with incident type 2 diabetes and performed two-sample bi-directional Mendelian randomization (MR) analysis to prioritize our results. Association analysis of prevalent type 2 diabetes revealed 24 replicated proteins, of which eight are novel. Proteins showing association with incident type 2 diabetes were aminoacylase-1, growth hormone receptor, and insulin-like growth factor binding protein-2. Aminoacylase-1 was associated with both prevalent and incident type 2 diabetes. MR analysis yielded nominally significant causal effects of type 2 diabetes on cathepsin Z and rennin, both known to have roles in the pathophysiological pathways of cardiovascular disease, and of sex hormone-binding globulin on type 2 diabetes. In conclusion, our high-throughput proteomics study replicated previously reported type 2 diabetes-protein associations, and identified new candidate proteins possibly involved in the pathogenesis of type 2 diabetes.

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