scholarly journals Soft Drink and Juice Consumption and Risk of Physician-diagnosed Incident Type 2 Diabetes: The Singapore Chinese Health Study

2010 ◽  
Vol 171 (6) ◽  
pp. 701-708 ◽  
Author(s):  
A. O. Odegaard ◽  
W.-P. Koh ◽  
K. Arakawa ◽  
M. C. Yu ◽  
M. A. Pereira
Keyword(s):  
Type 2 Diabetes ◽  
Soft Drink ◽  
Health Study ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Singapore Chinese

scholarly journals Dietary Patterns and Incident Type 2 Diabetes in Chinese Men and Women: The Singapore Chinese Health Study

Diabetes Care ◽  
2011 ◽  
Vol 34 (4) ◽  
pp. 880-885 ◽  
Author(s):  
A. O. Odegaard ◽  
W.-P. Koh ◽  
L. M. Butler ◽  
S. Duval ◽  
M. D. Gross ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Patterns ◽  
Health Study ◽  
Men And Women ◽  
Chinese Men ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Singapore Chinese

scholarly journals Omega-3 fatty acids and incident type 2 diabetes: the Singapore Chinese Health Study

2011 ◽  
Vol 94 (2) ◽  
pp. 520-526 ◽  
Author(s):  
Diana P Brostow ◽  
Andrew O Odegaard ◽  
Woon-Puay Koh ◽  
Sue Duval ◽  
Myron D Gross ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Health Study ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Singapore Chinese

scholarly journals Glycated Hemoglobin and Incident Type 2 Diabetes in Singaporean Chinese Adults: The Singapore Chinese Health Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119884 ◽  
Author(s):  
Michael P. Bancks ◽  
Andrew O. Odegaard ◽  
Woon-Puay Koh ◽  
Jian-Min Yuan ◽  
Myron D. Gross ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycated Hemoglobin ◽  
Health Study ◽  
Chinese Adults ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Singapore Chinese

scholarly journals Coffee, tea, and incident type 2 diabetes: the Singapore Chinese Health Study

2008 ◽  
Vol 88 (4) ◽  
pp. 979-985 ◽  
Author(s):  
Andrew O Odegaard ◽  
Mark A Pereira ◽  
Woon-Puay Koh ◽  
Kazuko Arakawa ◽  
Hin-Peng Lee ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Health Study ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Singapore Chinese

scholarly journals Deciphering the Plasma Proteome of Type 2 Diabetes

2020 ◽  
Author(s):  
Ada Admin ◽  
Mohamed A. Elhadad ◽  
Christian Jonasson ◽  
Cornelia Huth ◽  
Rory Wilson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Growth Hormone Receptor ◽  
Smoking Status ◽  
Underlying Disease ◽  
Sex Hormone Binding Globulin ◽  
Health Study ◽  
Study Cohort ◽  
Incident Type ◽  
Incident Type 2 Diabetes

With an estimated prevalence of 463 million affected, type 2 diabetes represents a major challenge to health care systems worldwide. Analyzing the plasma proteomes of individuals with type 2 diabetes may illuminate hitherto unknown functional mechanisms underlying disease pathology. We assessed the associations between type 2 diabetes and >1000 plasma proteins in the KORA (Cooperative health research in the Region of Augsburg) F4 cohort (n=993, 110 cases), with subsequent replication in the HUNT3 (Third wave of the Nord-Trøndelag Health Study) cohort (n=940, 149 cases). We computed logistic regression models adjusted for age, sex, BMI, smoking status and hypertension. Additionally, we investigated associations with incident type 2 diabetes and performed two-sample bi-directional Mendelian randomization (MR) analysis to prioritize our results. Association analysis of prevalent type 2 diabetes revealed 24 replicated proteins, of which eight are novel. Proteins showing association with incident type 2 diabetes were aminoacylase-1, growth hormone receptor, and insulin-like growth factor binding protein-2. Aminoacylase-1 was associated with both prevalent and incident type 2 diabetes. MR analysis yielded nominally significant causal effects of type 2 diabetes on cathepsin Z and rennin, both known to have roles in the pathophysiological pathways of cardiovascular disease, and of sex hormone-binding globulin on type 2 diabetes. In conclusion, our high-throughput proteomics study replicated previously reported type 2 diabetes-protein associations, and identified new candidate proteins possibly involved in the pathogenesis of type 2 diabetes.

scholarly journals Deciphering the Plasma Proteome of Type 2 Diabetes

2020 ◽  
Author(s):  
Ada Admin ◽  
Mohamed A. Elhadad ◽  
Christian Jonasson ◽  
Cornelia Huth ◽  
Rory Wilson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Growth Hormone Receptor ◽  
Smoking Status ◽  
Underlying Disease ◽  
Sex Hormone Binding Globulin ◽  
Health Study ◽  
Study Cohort ◽  
Incident Type ◽  
Incident Type 2 Diabetes

With an estimated prevalence of 463 million affected, type 2 diabetes represents a major challenge to health care systems worldwide. Analyzing the plasma proteomes of individuals with type 2 diabetes may illuminate hitherto unknown functional mechanisms underlying disease pathology. We assessed the associations between type 2 diabetes and >1000 plasma proteins in the KORA (Cooperative health research in the Region of Augsburg) F4 cohort (n=993, 110 cases), with subsequent replication in the HUNT3 (Third wave of the Nord-Trøndelag Health Study) cohort (n=940, 149 cases). We computed logistic regression models adjusted for age, sex, BMI, smoking status and hypertension. Additionally, we investigated associations with incident type 2 diabetes and performed two-sample bi-directional Mendelian randomization (MR) analysis to prioritize our results. Association analysis of prevalent type 2 diabetes revealed 24 replicated proteins, of which eight are novel. Proteins showing association with incident type 2 diabetes were aminoacylase-1, growth hormone receptor, and insulin-like growth factor binding protein-2. Aminoacylase-1 was associated with both prevalent and incident type 2 diabetes. MR analysis yielded nominally significant causal effects of type 2 diabetes on cathepsin Z and rennin, both known to have roles in the pathophysiological pathways of cardiovascular disease, and of sex hormone-binding globulin on type 2 diabetes. In conclusion, our high-throughput proteomics study replicated previously reported type 2 diabetes-protein associations, and identified new candidate proteins possibly involved in the pathogenesis of type 2 diabetes.

Abstract MP037: Plasma Organochlorine Concentration and Risk of Diabetes: the Nurses' Health Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Hongyu Wu ◽  
Kimberly A Bertrand ◽  
Anna L Choi ◽  
Frank B Hu ◽  
Francine Laden ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Polychlorinated Biphenyl ◽  
Plasma Concentrations ◽  
Diabetes Risk ◽  
Health Study ◽  
Blood Draw ◽  
Incident Type ◽  
Increased Risk ◽  
Incident Type 2 Diabetes

Background: Animal experiments have suggested that exposure to persistent organic pollutants (POPs) may lead to increased risk of type 2 diabetes. Although recent human studies supported this hypothesis, evidence from prospective investigations is sparse. Objective: To examine the associations of plasma POP concentrations with risk of incident type 2 diabetes in a prospective setting among US women. Methods: Study population was comprised of participants from two independent nested case-control studies in the Nurses’ Health Study, in which major polychlorinated biphenyl (PCB 118, 138, 153, and 180), p-p'- dichlorodiphenyldichloroethylene (DDE), dichlorodiphenyltrichloroethane (DDT), and hexachlorobenzene (HCB) were measured. A non-parametric approach was used to derive standardized scores for plasma concentrations of lipid-adjusted POPs within each study to minimize between-study variation of the POP measurements. Risk of incident type 2 diabetes during the follow-up period (1990-2008) across the tertiles of the scores was examined. Results: Of 1,120 participants, we identified 48 incident type 2 diabetes cases. After adjusting for covariates assessed at blood draw in 1990, including smoking status, body mass index, and total fish intake, plasma HCB concentration was positively associated with type 2 diabetes risk: odds ratio (OR) (95% confidence interval [CI]) was 2.77 (1.17, 6.55, P for trend =0.022) comparing the highest vs. lowest tertile. Other POPs were not significantly associated with diabetes: the ORs (95% CI) were 1.10 (0.51, 2.34, P for trend =0.81) for p-p'-DDE, 0.93 (0.44, 1.95, P for trend =0.86) for DDT, and 0.88 (0.39, 1.97, P for trend =0.76) for sum of the 4 major PCBs, comparing the extreme tertiles. Conclusion: The significant association of plasma HCB concentration with diabetes risk supports a role of POP exposure in the etiology of type 2 diabetes. More prospective data are warranted to confirm these findings.

scholarly journals Islet amyloid polypeptide gene variation (IAPP) and the risk of incident type 2 diabetes mellitus: The women's genome health study

2011 ◽  
Vol 412 (9-10) ◽  
pp. 785-787 ◽  
Author(s):  
Robert Y.L. Zee ◽  
Patricia Pulido-Perez ◽  
Ricardo Perez-Fuentes ◽  
Paul M Ridker ◽  
Daniel I. Chasman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Islet Amyloid Polypeptide ◽  
Health Study ◽  
Islet Amyloid ◽  
Incident Type ◽  
Gene Variation ◽  
Incident Type 2 Diabetes
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