scholarly journals Serum 25-Hydroxyvitamin D, Calcium Intake, and Risk of Type 2 Diabetes After 5 Years: Results from a national, population-based prospective study (the Australian Diabetes, Obesity and Lifestyle study)

Diabetes Care ◽  
2011 ◽  
Vol 34 (5) ◽  
pp. 1133-1138 ◽  
Author(s):  
C. Gagnon ◽  
Z. X. Lu ◽  
D. J. Magliano ◽  
D. W. Dunstan ◽  
J. E. Shaw ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Prospective Study ◽  
Calcium Intake ◽  
Population Based ◽  
National Population ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Vitamin D Status, Calcium Intake and Risk of Developing Type 2 Diabetes: An Unresolved Issue

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 642 ◽  
Author(s):  
Araceli Muñoz-Garach ◽  
Beatriz García-Fontana ◽  
Manuel Muñoz-Torres
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Clinical Trials ◽  
Calcium Intake ◽  
Observational Studies ◽  
Randomized Clinical Trials ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

The relationship between vitamin D status, calcium intake and the risk of developing type 2 diabetes (T2D) is a topic of growing interest. One of the most interesting non-skeletal functions of vitamin D is its potential role in glucose homeostasis. This possible association is related to the secretion of insulin by pancreatic beta cells, insulin resistance in different tissues and its influence on systemic inflammation. However, despite multiple observational studies and several meta-analyses that have shown a positive association between circulating 25-hydroxyvitamin D concentrations and the risk of T2D, no randomized clinical trials supplementing with different doses of vitamin D have confirmed this hypothesis definitively. An important question is the identification of what 25-hydroxyvitamin D levels are necessary to influence glycemic homeostasis and the risk of developing T2D. These values of vitamin D can be significantly higher than vitamin D levels required for bone health, but the currently available data do not allow us to answer this question adequately. Furthermore, a large number of observational studies show that dairy consumption is linked to a lower risk of T2D, but the components responsible for this relationship are not well established. Therefore, the importance of calcium intake in the risk of developing T2D has not yet been established. Although there is a biological plausibility linking the status of vitamin D and calcium intake with the risk of T2D, well-designed randomized clinical trials are necessary to answer this important question.

scholarly journals Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jing Xiao ◽  
Jingyi Lv ◽  
Shiyu Wang ◽  
Yang Zhou ◽  
Lunwen Chen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Mendelian Randomization ◽  
Middle Aged ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Randomization Analysis

Abstract Background Vitamin D deficiency has been associated with type 2 diabetes (T2D) and metabolic syndrome (MS) and its components. However, it is unclear whether a low concentration of vitamin D is the cause or consequence of these health conditions. Thus, this study aimed to evaluate the association of vitamin D concentrations and its genetic risk scores (GRSs) with MS and its component diseases, such as T2D, in middle-aged and elderly participants from rural eastern China. Methods A subset of 2393 middle-aged and elderly individuals were selected from 70,458 participants of the Nantong Chronic Diseases Study of 2017–2018 in China. We used two 25-hydroxyvitamin D (25[OH]D) synthesis single-nucleotide polymorphisms (SNPs) (DHCR7-rs12785878 and CYP2R1-rs10741657) and two 25(OH) D metabolism SNPs (GC-rs2282679 and CYP24A1-rs6013897) for creating GRSs, which were used as instrumental variables to assess the effect of genetically lowered 25(OH) D concentrations on MS and T2D based on the Wald ratio. F statistics were used to validate that the four SNPs genetically determined 25(OH) D concentrations. Results Compared to vitamin D sufficient individuals, individuals with vitamin D insufficiency had an odds ratio (OR [95% confidence interval {CI}]) of MS of 1.30 (1.06–1.61) and of T2D of 1.32 (1.08–1.64), individuals with vitamin D deficiency had an ORs (95% CI) of MS of 1.50 (1.24–1.79) and of T2D of 1.47 (1.12–1.80), and those with vitamin D severe deficiency had an ORs (95% CI) of MS of 1.52 (1.29–1.85) and of T2D of 1.54 (1.27–1.85). Mendelian randomization analysis showed a 25-nmol/L decrease in genetically instrumented serum 25(OH) D concentrations using the two synthesis SNPs (DHCR7 and CYP2R1 genes) associated with the risk of T2D and abnormal diastolic blood pressure (DBP) with ORs of 1.10 (95%CI: 1.02–1.45) for T2D and 1.14 (95%CI: 1.03–1.43) for DBP. Conclusions This one sample Mendelian randomization analysis shows genetic evidence for a causal role of lower 25(OH) D concentrations in promoting of T2D and abnormal DBP in middle-aged and elderly participants from rural China.

Correlations between serum levels of 25-hydroxyvitamin D and carotid atherosclerosis in patients with type 2 diabetes in Shanghai

2014 ◽  
Vol 75 (4) ◽  
pp. 206-212 ◽  
Author(s):  
Rui-hua Chen ◽  
Xiao-zhen Jiang ◽  
Quan Jiang ◽  
Zhe Gu ◽  
Pei-li Gu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Carotid Atherosclerosis ◽  
Serum Levels ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals FTO-rs9939609 Polymorphism is a Predictor of Future Type 2 Diabetes: A Population-Based Prospective Study

2021 ◽  
Author(s):  
Tran Quang Binh ◽  
Duong Tuan Linh ◽  
Le Thi Kim Chung ◽  
Pham Tran Phuong ◽  
Bui Thi Thuy Nga ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Prospective Study ◽  
Population Based ◽  
Fto Rs9939609

scholarly journals The association of serum 25-hydroxyvitamin D and vertebral fractures in patients with type 2 diabetes

2013 ◽  
pp. 179-184 ◽  
Author(s):  
Yoon Ji Kim ◽  
Seok O Park ◽  
Tae Ho Kim ◽  
Jae Hyuk Lee ◽  
Se Hwa Kim
Keyword(s):  
Type 2 Diabetes ◽  
Vertebral Fractures ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study

2010 ◽  
Vol 91 (6) ◽  
pp. 1627-1633 ◽  
Author(s):  
Enju Liu ◽  
James B Meigs ◽  
Anastassios G Pittas ◽  
Christina D Economos ◽  
Nicola M McKeown ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Incident Type ◽  
Hydroxyvitamin D ◽  
Incident Type 2 Diabetes ◽  
25 Hydroxyvitamin D

scholarly journals Serum 25-Hydroxyvitamin D Concentration and Subsequent Risk of Type 2 Diabetes

Diabetes Care ◽  
2007 ◽  
Vol 30 (10) ◽  
pp. 2569-2570 ◽  
Author(s):  
C. Mattila ◽  
P. Knekt ◽  
S. Mannisto ◽  
H. Rissanen ◽  
M. A. Laaksonen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Subsequent Risk
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