scholarly journals Serum 25-Hydroxyvitamin D Concentration and Subsequent Risk of Type 2 Diabetes

Diabetes Care ◽  
2007 ◽  
Vol 30 (10) ◽  
pp. 2569-2570 ◽  
Author(s):  
C. Mattila ◽  
P. Knekt ◽  
S. Mannisto ◽  
H. Rissanen ◽  
M. A. Laaksonen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Subsequent Risk

scholarly journals Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jing Xiao ◽  
Jingyi Lv ◽  
Shiyu Wang ◽  
Yang Zhou ◽  
Lunwen Chen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Mendelian Randomization ◽  
Middle Aged ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Randomization Analysis

Abstract Background Vitamin D deficiency has been associated with type 2 diabetes (T2D) and metabolic syndrome (MS) and its components. However, it is unclear whether a low concentration of vitamin D is the cause or consequence of these health conditions. Thus, this study aimed to evaluate the association of vitamin D concentrations and its genetic risk scores (GRSs) with MS and its component diseases, such as T2D, in middle-aged and elderly participants from rural eastern China. Methods A subset of 2393 middle-aged and elderly individuals were selected from 70,458 participants of the Nantong Chronic Diseases Study of 2017–2018 in China. We used two 25-hydroxyvitamin D (25[OH]D) synthesis single-nucleotide polymorphisms (SNPs) (DHCR7-rs12785878 and CYP2R1-rs10741657) and two 25(OH) D metabolism SNPs (GC-rs2282679 and CYP24A1-rs6013897) for creating GRSs, which were used as instrumental variables to assess the effect of genetically lowered 25(OH) D concentrations on MS and T2D based on the Wald ratio. F statistics were used to validate that the four SNPs genetically determined 25(OH) D concentrations. Results Compared to vitamin D sufficient individuals, individuals with vitamin D insufficiency had an odds ratio (OR [95% confidence interval {CI}]) of MS of 1.30 (1.06–1.61) and of T2D of 1.32 (1.08–1.64), individuals with vitamin D deficiency had an ORs (95% CI) of MS of 1.50 (1.24–1.79) and of T2D of 1.47 (1.12–1.80), and those with vitamin D severe deficiency had an ORs (95% CI) of MS of 1.52 (1.29–1.85) and of T2D of 1.54 (1.27–1.85). Mendelian randomization analysis showed a 25-nmol/L decrease in genetically instrumented serum 25(OH) D concentrations using the two synthesis SNPs (DHCR7 and CYP2R1 genes) associated with the risk of T2D and abnormal diastolic blood pressure (DBP) with ORs of 1.10 (95%CI: 1.02–1.45) for T2D and 1.14 (95%CI: 1.03–1.43) for DBP. Conclusions This one sample Mendelian randomization analysis shows genetic evidence for a causal role of lower 25(OH) D concentrations in promoting of T2D and abnormal DBP in middle-aged and elderly participants from rural China.

Correlations between serum levels of 25-hydroxyvitamin D and carotid atherosclerosis in patients with type 2 diabetes in Shanghai

2014 ◽  
Vol 75 (4) ◽  
pp. 206-212 ◽  
Author(s):  
Rui-hua Chen ◽  
Xiao-zhen Jiang ◽  
Quan Jiang ◽  
Zhe Gu ◽  
Pei-li Gu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Carotid Atherosclerosis ◽  
Serum Levels ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals The association of serum 25-hydroxyvitamin D and vertebral fractures in patients with type 2 diabetes

2013 ◽  
pp. 179-184 ◽  
Author(s):  
Yoon Ji Kim ◽  
Seok O Park ◽  
Tae Ho Kim ◽  
Jae Hyuk Lee ◽  
Se Hwa Kim
Keyword(s):  
Type 2 Diabetes ◽  
Vertebral Fractures ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study

2010 ◽  
Vol 91 (6) ◽  
pp. 1627-1633 ◽  
Author(s):  
Enju Liu ◽  
James B Meigs ◽  
Anastassios G Pittas ◽  
Christina D Economos ◽  
Nicola M McKeown ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Incident Type ◽  
Hydroxyvitamin D ◽  
Incident Type 2 Diabetes ◽  
25 Hydroxyvitamin D

scholarly journals Plasma 25-Hydroxyvitamin D Concentration and Risk of Incident Type 2 Diabetes in Women

Diabetes Care ◽  
2010 ◽  
Vol 33 (9) ◽  
pp. 2021-2023 ◽  
Author(s):  
A. G. Pittas ◽  
Q. Sun ◽  
J. E. Manson ◽  
B. Dawson-Hughes ◽  
F. B. Hu
Keyword(s):  
Type 2 Diabetes ◽  
Incident Type ◽  
Hydroxyvitamin D ◽  
Incident Type 2 Diabetes ◽  
25 Hydroxyvitamin D
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