scholarly journals Secular Trends in Treatment and Control of Type 2 Diabetes in an American Indian Population: A 30-Year Longitudinal Study

Diabetes Care ◽  
2010 ◽  
Vol 33 (11) ◽  
pp. 2383-2389 ◽  
Author(s):  
H. C. Looker ◽  
J. Krakoff ◽  
V. Andre ◽  
K. Kobus ◽  
R. G. Nelson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Longitudinal Study ◽  
American Indian ◽  
Indian Population ◽  
Secular Trends ◽  
American Indian Population ◽  
And Control

Effect of severe obesity in childhood and adolescence on risk of type 2 diabetes in youth and early adulthood in an American Indian population

2017 ◽  
Vol 19 (4) ◽  
pp. 622-629 ◽  
Author(s):  
Stephanie K Tanamas ◽  
Sanil P Reddy ◽  
Melissa A Chambers ◽  
Elena J Clark ◽  
Diana L Dunnigan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
American Indian ◽  
Indian Population ◽  
Severe Obesity ◽  
Early Adulthood ◽  
Childhood And Adolescence ◽  
American Indian Population ◽  
Diabetes In Youth

scholarly journals Role of Established Type 2 Diabetes–Susceptibility Genetic Variants in a High Prevalence American Indian Population

Diabetes ◽  
2015 ◽  
Vol 64 (7) ◽  
pp. 2646-2657 ◽  
Author(s):  
Robert L. Hanson ◽  
Rong Rong ◽  
Sayuko Kobes ◽  
Yunhua Li Muller ◽  
E. Jennifer Weil ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
American Indian ◽  
Genetic Variants ◽  
Indian Population ◽  
Diabetes Susceptibility ◽  
American Indian Population ◽  
High Prevalence

scholarly journals Association of Genetic Variants of KCNJ11 and KCNQ1 Genes with Risk of Type 2 Diabetes Mellitus (T2DM) in the Indian Population: A Case-Control Study

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Vasiuddin Khan ◽  
Amit Kumar Verma ◽  
Deepti Bhatt ◽  
Shahbaz Khan ◽  
Rameez Hasan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Genetic Variants ◽  
Indian Population ◽  
Clinicopathological Characteristics ◽  
Variant Allele ◽  
Significant Difference ◽  
And Control

Type 2 diabetes mellitus (T2DM) is a polygenic metabolic disease described by hyperglycemia, which is caused by insulin resistance or reduced insulin secretion. The interaction between various genetic variants and environmental factors triggers T2DM. The aim of this study was to find risk associated with genetic variants rs5210 and rs2237895 of KCNJ11 and KCNQ1 genes, respectively, in the development of T2DM in the Indian population. A total number of 300 cases of T2DM and 100 control samples were studied to find the polymorphism in KCNJ11 and KCNQ1 through PCR-RFLP. The genotype and allele frequencies in T2DM cases were significantly different compared to the control population. KCNJ11 rs5210 and KCNQ1 rs2237895 variants were found to be significantly associated with risk of T2DM in dominant (KCNJ11: OR, 2.07; 95% CI, 1.30–3.27; p−0.001; KCNQ1: OR, 2.33; 95% CI, 1.46–3.70; p−0.0003) and codominant models (KCNJ11: OR, 1.76; 95% CI, 1.09–2.84; p−0.020; KCNQ1: OR, 1.85; 95% CI, 1.16–2.95; p−0.009). We also compared clinicopathological characteristics between cases and control and observed a significant difference in all the parameters except HDL, gender, and family history. In this study, clinicopathological data with a carrier of a variant allele of both KCNJ11 and KCNQ1 genes were also analysed, and a significant association was found between the carrier of a variant allele with gender and PPG in KCNJ11 and with triglyceride in KCNQ1. We confirm the significant association of KCNJ11 (rs5210) and KCNQ1 (rs2237895) gene polymorphism with T2DM, indicating the role of these variants in developing risk for T2DM in Indian population.

scholarly journals Serum lipids and mortality in an American Indian population: A longitudinal study

2018 ◽  
Vol 32 (1) ◽  
pp. 18-26 ◽  
Author(s):  
Stephanie K. Tanamas ◽  
Pierre-Jean Saulnier ◽  
Robert L. Hanson ◽  
Robert G. Nelson ◽  
Wen-Chi Hsueh ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
American Indian ◽  
Serum Lipids ◽  
Indian Population ◽  
American Indian Population

1701-P: Genome-Wide Association Study Identifies Novel Potential Associations with Birth Weight in a Southwestern American Indian Population

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1701-P
Author(s):  
LAUREN E. WEDEKIND ◽  
WEN-CHI HSUEH ◽  
SAYUKO KOBES ◽  
MUIDEEN T. OLAIYA ◽  
WILLIAM C. KNOWLER ◽  
...  
Keyword(s):  
Birth Weight ◽  
American Indian ◽  
Association Study ◽  
Indian Population ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
American Indian Population ◽  
Genome Wide

Relative risk of cardiovascular disease is higher in women with type 2 diabetes, but not in those with prediabetes, as compared with men

2020 ◽  
Author(s):  
Elena Succurro ◽  
Teresa Vanessa Fiorentino ◽  
Sofia Miceli ◽  
Maria Perticone ◽  
Angela Sciacqua ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Longitudinal Study ◽  
Relative Risk ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Adverse Outcomes ◽  
Cross Sectional ◽  
Normal Glucose

<b>Objective</b>: Most, but not all studies suggested that women with type 2 diabetes have higher relative risk (RR) for cardiovascular disease (CVD) than men. More uncertainty exists on whether the RR for CVD is higher in prediabetic women compared to men. <p><b>Research Design and Methods</b>: In a cross-sectional study, in 3540 normal glucose tolerant (NGT), prediabetic, and diabetic adults, we compared the RR for prevalent non-fatal CVD between men and women. In a longitudinal study including 1658 NGT, prediabetic, and diabetic adults, we compared the RR for incident major adverse outcomes, including all-cause death, coronary heart disease, and cerebrovascular disease events after 5.6 years follow-up. </p> <p><b>Results:</b> Women with prediabetes and diabetes exhibited greater relative differences in BMI, waist circumference, blood pressure, total, LDL and HDL cholesterol, triglycerides, fasting glucose, hsCRP, and white blood cell count than men with prediabetes and diabetes when compared with their NGT counterparts. We found a higher RR for prevalent CVD in diabetic women (RR 9.29; 95% CI 4.73-18.25; <i>P</i><0.0001) than in men (RR 4.56; 95% CI 3.07-6.77; <i>P</i><0.0001), but no difference in RR for CVD was observed comparing prediabetic women and men. In the longitudinal study, we found that diabetic, but not prediabetic women have higher RR (RR 5.25; 95% CI 3.22-8.56; <i>P</i><0.0001) of incident major adverse outcomes than their male counterparts (RR 2.72; 95% CI 1.81-4.08; <i>P</i><0.0001).</p> <p><b>Conclusions:</b> This study suggests that diabetic, but not prediabetic, women have higher RR for prevalent and incident major adverse outcomes than men. </p>

Epidemiology of Hypertension and Diabetes Mellitus in Latin America

2020 ◽  
Vol 16 ◽  
Author(s):  
Patricio Lopez-Jaramillo ◽  
Jose Lopez-Lopez ◽  
Daniel Cohen ◽  
Natalia Alarcon-Ariza ◽  
Margarita Mogollon-Zehr
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Latin America ◽  
Cardiovascular Diseases ◽  
Latin American ◽  
Premature Mortality ◽  
Increased Risk ◽  
And Control

: Hypertension and type 2 diabetes mellitus are two important risk factors that contribute to cardiovascular diseases worldwide. In Latin America hypertension prevalence varies from 30 to 50%. Moreover, the proportion of awareness, treatment and control of hypertension is very low. The prevalence of type 2 diabetes mellitus varies from 8 to 13% and near to 40% are unaware of their condition. In addition, the prevalence of prediabetes varies from 6 to 14% and this condition has been also associated with increased risk of cardiovascular diseases. The principal factors linked to a higher risk of hypertension in Latin America are increased adiposity, low muscle strength, unhealthy diet, low physical activity and low education. Besides being chronic conditions, leading causes of cardiovascular mortality, both hypertension and type 2 diabetes mellitus represent a substantial cost for the weak health systems of Latin American countries. Therefore, is necessary to implement and reinforce public health programs to improve awareness, treatment and control of hypertension and type 2 diabetes mellitus, in order to reach the mandate of the Unit Nations of decrease the premature mortality for CVD.

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