scholarly journals From Pre-Diabetes to Type 2 Diabetes in Obese Youth: Pathophysiological characteristics along the spectrum of glucose dysregulation

Diabetes Care ◽  
2010 ◽  
Vol 33 (10) ◽  
pp. 2225-2231 ◽  
Author(s):  
F. Bacha ◽  
S. Lee ◽  
N. Gungor ◽  
S. A. Arslanian
Keyword(s):  
Type 2 Diabetes ◽  
Obese Youth ◽  
Glucose Dysregulation

1746-P: Obese Youth with Type 1 Diabetes (T1D) Have Worse Hepatic Insulin Resistance (IR) Than Youth with Type 2 Diabetes (T2D)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1746-P
Author(s):  
PATTARA WIROMRAT ◽  
MELANIE CREE-GREEN ◽  
BRYAN C. BERGMAN ◽  
KALIE L. TOMMERDAHL ◽  
AMY BAUMGARTNER ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Hepatic Insulin Resistance ◽  
Obese Youth

Brain gray matter volume differences in obese youth with type 2 diabetes: a pilot study

2018 ◽  
Vol 31 (3) ◽  
pp. 261-268 ◽  
Author(s):  
Jacob M. Redel ◽  
Mark DiFrancesco ◽  
Jennifer Vannest ◽  
Mekibib Altaye ◽  
Dean Beebe ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Pilot Study ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Brain Magnetic Resonance Imaging ◽  
Direct Result ◽  
Intracranial Volume ◽  
Matter Volume ◽  
Obese Youth

AbstractBackground:Adults with type 2 diabetes (T2D) have significantly lower gray matter volume (GMV) compared to healthy peers. Whether GMV differences exist in youth with T2D remains unclear. Thus, we compared global and regional GMV between obese youth with T2D with age, race and sex similar healthy controls.Methods:In a cross-sectional study, 20 obese youth with T2D underwent T1-weighted brain magnetic resonance imaging (MRI). Comparisons were made to 20 age, race and sex similar controls. Differences in global and regional GMV between groups were identified using voxel-based morphometry (VBM).Results:Youth with T2D had a significantly lower global GMV-to-intracranial volume ratio (0.51±0.02 in T2D vs. 0.53±0.02 in controls, p=0.02, Cohen’sd=0.85). There were 14 regions where GMV was significantly lower in the T2D group, and nine of these were found in either the temporal or occipital lobes. There were six regions with increased GMV in T2D. All regional differences were significant at p<0.05 after adjusting for multiple comparisons.Conclusions:Results from this pilot study show obese youth with T2D have significantly lower global GMV and regional GMV differences, when compared to their age, race and sex similar peers. Future work is needed to determine whether these brain findings are a direct result of adolescent-onset T2D.

scholarly journals Dietary determinants of hepatic steatosis and visceral adiposity in overweight and obese youth at risk of type 2 diabetes

2014 ◽  
Vol 99 (4) ◽  
pp. 804-812 ◽  
Author(s):  
R. C. Mollard ◽  
M. Senechal ◽  
A. C. MacIntosh ◽  
J. Hay ◽  
B. A. Wicklow ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
At Risk ◽  
Hepatic Steatosis ◽  
Visceral Adiposity ◽  
Obese Youth ◽  
Youth At Risk

scholarly journals Adipocytokine Associations with Insulin Resistance in British South Asians

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
D. R. Webb ◽  
K. Khunti ◽  
S. Chatterjee ◽  
J. Jarvis ◽  
M. J. Davies
Keyword(s):  
Metabolic Disease ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
South Asian ◽  
South Asians ◽  
Risk Groups ◽  
Serum Samples ◽  
Asian Populations ◽  
Glucose Dysregulation

Aims. Adipocytokines are implicated in the pathogenesis of type 2 diabetes and may represent identifiable precursors of metabolic disease within high-risk groups. We investigated adiponectin, leptin, and TNF-αand assessed the contribution of these molecules to insulin resistance in south Asians.Hypothesis. South Asians have adverse adipocytokine profiles which associate with an HOMA-derived insulin resistance phenotype.Methods. We measured adipocytokine concentrations in south Asians with newly diagnosed impaired glucose tolerance or Type 2 Diabetes Mellitus in a case-control study. 158 (48.5% males) volunteers aged 25–75 years with risk factors for diabetes but no known vascular or metabolic disease provided serum samples for ELISA and bioplex assays.Results. Total adiponectin concentration progressively decreased across the glucose spectrum in both sexes. A reciprocal trend in leptin concentration was observed only in south Asian men. Adiponectin but not leptin independently associated with HOMA-derived insulin resistance after logistic multivariate regression.Conclusion. Diasporic south Asian populations have an adverse adipocytokine profile which deteriorates further with glucose dysregulation. Insulin resistance is inversely associated with adiponectin independent of BMI and waist circumference in south Asians, implying that adipocytokine interplay contributes to the pathogenesis of metabolic disease in this group.

scholarly journals Beta cell function and insulin sensitivity in obese youth with maturity onset diabetes of youth mutations vs type 2 diabetes in TODAY: Longitudinal observations and glycemic failure

2020 ◽  
Vol 21 (4) ◽  
pp. 575-585
Author(s):  
Silva Arslanian ◽  
Laure El ghormli ◽  
Morey H. Haymond ◽  
Christine L. Chan ◽  
Steven D. Chernausek ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Sensitivity ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Maturity Onset Diabetes ◽  
Onset Diabetes ◽  
Obese Youth

Time to Glucose Peak during Oral Glucose Tolerance Test (OGTT) and Pathophysiological Biomarkers of Type 2 Diabetes in Obese Youth

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1335-P
Author(s):  
JOON YOUNG KIM ◽  
HALA TFAYLI ◽  
FIDA BACHA ◽  
SARA MICHALISZYN ◽  
SILVA A. ARSLANIAN
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Obese Youth

scholarly journals β-Cell Function, Incretin Effect, and Incretin Hormones in Obese Youth Along the Span of Glucose Tolerance From Normal to Prediabetes to Type 2 Diabetes

Diabetes ◽  
2014 ◽  
Vol 63 (11) ◽  
pp. 3846-3855 ◽  
Author(s):  
Sara F. Michaliszyn ◽  
Andrea Mari ◽  
SoJung Lee ◽  
Fida Bacha ◽  
Hala Tfayli ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Cell Function ◽  
Incretin Hormones ◽  
Incretin Effect ◽  
Β Cell ◽  
Obese Youth ◽  
Β Cell Function

scholarly journals The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test Heralds Biomarkers of Type 2 Diabetes Risk in Obese Youth

Diabetes Care ◽  
2016 ◽  
Vol 39 (8) ◽  
pp. 1431-1439 ◽  
Author(s):  
Joon Young Kim ◽  
Sara F. Michaliszyn ◽  
Alexis Nasr ◽  
SoJung Lee ◽  
Hala Tfayli ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Response Curve ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Glucose Response ◽  
Obese Youth
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