scholarly journals Epidemiological Perspectives on Type 1 Diabetes in Childhood and Adolescence in Germany: 20 years of the Baden-Wurttemberg Diabetes Incidence Registry (DIARY)

Diabetes Care ◽  
2009 ◽  
Vol 33 (2) ◽  
pp. 338-340 ◽  
Author(s):  
S. Ehehalt ◽  
K. Dietz ◽  
A. M. Willasch ◽  
A. Neu ◽  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetes Incidence ◽  
Childhood And Adolescence ◽  
Diabetes In Childhood

scholarly journals Perinatal factors and the risk of type 1 diabetes in childhood and adolescence—A register‐based case‐cohort study in Finland, years 1987 to 2009

2020 ◽  
Vol 21 (4) ◽  
pp. 586-596
Author(s):  
Johanna Metsälä ◽  
Leena Hakola ◽  
Annamari Lundqvist ◽  
Lauri J. Virta ◽  
Mika Gissler ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Childhood And Adolescence ◽  
Perinatal Factors ◽  
Diabetes In Childhood

scholarly journals Diabetic ketoacidosis at manifestation of type 1 diabetes in childhood and adolescence

2021 ◽  
Author(s):  
Hugo Segerer ◽  
Michael Wurm ◽  
Julia M. Grimsmann ◽  
Beate Karges ◽  
Andreas Neu ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Ketoacidosis ◽  
Childhood And Adolescence ◽  
Diabetes In Childhood

scholarly journals Does Periodontal Inflammation Affect Type 1 Diabetes in Childhood and Adolescence? A Meta-Analysis

2020 ◽  
Vol 11 ◽  
Author(s):  
Biagio Rapone ◽  
Massimo Corsalini ◽  
Ilaria Converti ◽  
Maria Teresa Loverro ◽  
Antonio Gnoni ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Meta Analysis ◽  
Childhood And Adolescence ◽  
Diabetes In Childhood ◽  
Periodontal Inflammation

Hemoglobin A1c is a reliable criterion for diagnosing type 1 diabetes in childhood and adolescence

2010 ◽  
Vol 11 (7) ◽  
pp. 446-449 ◽  
Author(s):  
Stefan Ehehalt ◽  
Nils Gauger ◽  
Gunnar Blumenstock ◽  
Lutz Feldhahn ◽  
Thomas Scheffner ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Hemoglobin A1c ◽  
Childhood And Adolescence ◽  
Reliable Criterion ◽  
Diabetes In Childhood

scholarly journals DR15-DQ6 remains dominantly protective against type 1 diabetes throughout the first five decades of life

Diabetologia ◽  
2021 ◽  
Author(s):  
Nicholas J. Thomas ◽  
John M. Dennis ◽  
Seth A. Sharp ◽  
Akaal Kaur ◽  
Shivani Misra ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Major Type ◽  
Diabetes Incidence ◽  
Diabetes Diagnosis ◽  
Risk Haplotype ◽  
Adult Onset ◽  
Uk Biobank ◽  
Onset Type ◽  
Increased Risk

Abstract Aims/hypothesis Among white European children developing type 1 diabetes, the otherwise common HLA haplotype DR15-DQ6 is rare, and highly protective. Adult-onset type 1 diabetes is now known to represent more overall cases than childhood onset, but it is not known whether DR15-DQ6 is protective in older-adult-onset type 1 diabetes. We sought to quantify DR15-DQ6 protection against type 1 diabetes as age of onset increased. Methods In two independent cohorts we assessed the proportion of type 1 diabetes cases presenting through the first 50 years of life with DR15-DQ6, compared with population controls. In the After Diabetes Diagnosis Research Support System-2 (ADDRESS-2) cohort (n = 1458) clinician-diagnosed type 1 diabetes was confirmed by positivity for one or more islet-specific autoantibodies. In UK Biobank (n = 2502), we estimated type 1 diabetes incidence rates relative to baseline HLA risk for each HLA group using Poisson regression. Analyses were restricted to white Europeans and were performed in three groups according to age at type 1 diabetes onset: 0–18 years, 19–30 years and 31–50 years. Results DR15-DQ6 was protective against type 1 diabetes through to age 50 years (OR < 1 for each age group, all p < 0.001). The following ORs for type 1 diabetes, relative to a neutral HLA genotype, were observed in ADDRESS-2: age 5–18 years OR 0.16 (95% CI 0.08, 0.31); age 19–30 years OR 0.10 (0.04, 0.23); and age 31–50 years OR 0.37 (0.21, 0.68). DR15-DQ6 also remained highly protective at all ages in UK Biobank. Without DR15-DQ6, the presence of major type 1 diabetes high-risk haplotype (either DR3-DQ2 or DR4-DQ8) was associated with increased risk of type 1 diabetes. Conclusions/interpretation HLA DR15-DQ6 confers dominant protection from type 1 diabetes across the first five decades of life. Graphical abstract

Excess mortality in Type 1 diabetes diagnosed in childhood and adolescence: a systematic review of population-based cohorts

2015 ◽  
Vol 52 (4) ◽  
pp. 801-807 ◽  
Author(s):  
Eileen Morgan ◽  
Christopher R. Cardwell ◽  
Catherine J. Black ◽  
David R. McCance ◽  
Christopher C. Patterson
Keyword(s):  
Systematic Review ◽  
Type 1 Diabetes ◽  
Excess Mortality ◽  
Population Based ◽  
Childhood And Adolescence

scholarly journals pH of Drinking Water Influences the Composition of Gut Microbiome and Type 1 Diabetes Incidence

Diabetes ◽  
2013 ◽  
Vol 63 (2) ◽  
pp. 632-644 ◽  
Author(s):  
M. H. Sofi ◽  
R. Gudi ◽  
S. Karumuthil-Melethil ◽  
N. Perez ◽  
B. M. Johnson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Drinking Water ◽  
Gut Microbiome ◽  
Diabetes Incidence
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