scholarly journals Perinatal factors and the risk of type 1 diabetes in childhood and adolescence—A register‐based case‐cohort study in Finland, years 1987 to 2009

2020 ◽  
Vol 21 (4) ◽  
pp. 586-596
Author(s):  
Johanna Metsälä ◽  
Leena Hakola ◽  
Annamari Lundqvist ◽  
Lauri J. Virta ◽  
Mika Gissler ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Childhood And Adolescence ◽  
Perinatal Factors ◽  
Diabetes In Childhood

scholarly journals Diabetic ketoacidosis at manifestation of type 1 diabetes in childhood and adolescence

2021 ◽  
Author(s):  
Hugo Segerer ◽  
Michael Wurm ◽  
Julia M. Grimsmann ◽  
Beate Karges ◽  
Andreas Neu ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Ketoacidosis ◽  
Childhood And Adolescence ◽  
Diabetes In Childhood

scholarly journals Does Periodontal Inflammation Affect Type 1 Diabetes in Childhood and Adolescence? A Meta-Analysis

2020 ◽  
Vol 11 ◽  
Author(s):  
Biagio Rapone ◽  
Massimo Corsalini ◽  
Ilaria Converti ◽  
Maria Teresa Loverro ◽  
Antonio Gnoni ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Meta Analysis ◽  
Childhood And Adolescence ◽  
Diabetes In Childhood ◽  
Periodontal Inflammation

Hemoglobin A1c is a reliable criterion for diagnosing type 1 diabetes in childhood and adolescence

2010 ◽  
Vol 11 (7) ◽  
pp. 446-449 ◽  
Author(s):  
Stefan Ehehalt ◽  
Nils Gauger ◽  
Gunnar Blumenstock ◽  
Lutz Feldhahn ◽  
Thomas Scheffner ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Hemoglobin A1c ◽  
Childhood And Adolescence ◽  
Reliable Criterion ◽  
Diabetes In Childhood

scholarly journals Paediatric rotavirus vaccination, coeliac disease and type 1 diabetes in children: a population-based cohort study

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Thomas Inns ◽  
Kate M. Fleming ◽  
Miren Iturriza-Gomara ◽  
Daniel Hungerford
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Coeliac Disease ◽  
Practice Research ◽  
Clinical Practice Research Datalink ◽  
Rotavirus Vaccine ◽  
Rotavirus Vaccination ◽  
Increased Risk ◽  
The Uk

Abstract Background Rotavirus infection has been proposed as a risk factor for coeliac disease (CD) and type 1 diabetes (T1D). The UK introduced infant rotavirus vaccination in 2013. We have previously shown that rotavirus vaccination can have beneficial off-target effects on syndromes, such as hospitalised seizures. We therefore investigated whether rotavirus vaccination prevents CD and T1D in the UK. Methods A cohort study of children born between 2010 and 2015 was conducted using primary care records from the Clinical Practice Research Datalink. Children were followed up from 6 months to 7 years old, with censoring for outcome, death or leaving the practice. CD was defined as diagnosis of CD or the prescription of gluten-free goods. T1D was defined as a T1D diagnosis. The exposure was rotavirus vaccination, defined as one or more doses. Mixed-effects Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CIs). Models were adjusted for potential confounders and included random intercepts for general practices. Results There were 880,629 children in the cohort (48.8% female). A total of 343,113 (39.0%) participants received rotavirus vaccine; among those born after the introduction of rotavirus vaccination, 93.4% were vaccinated. Study participants contributed 4,388,355 person-years, with median follow-up 5.66 person-years. There were 1657 CD cases, an incidence of 38.0 cases per 100,000 person-years. Compared with unvaccinated children, the adjusted HR for a CD was 1.05 (95% CI 0.86–1.28) for vaccinated children. Females had a 40% higher hazard than males. T1D was recorded for 733 participants, an incidence of 17.1 cases per 100,000 person-years. In adjusted analysis, rotavirus vaccination was not associated with risk of T1D (HR = 0.89, 95% CI 0.68–1.19). Conclusions Rotavirus vaccination has reduced diarrhoeal disease morbidity and mortality substantial since licencing in 2006. Our finding from this large cohort study did not provide evidence that rotavirus vaccination prevents CD or T1D, nor is it associated with increased risk, delivering further evidence of rotavirus vaccine safety.

Sign in / Sign up

Export Citation Format

Share Document