scholarly journals Body Iron Stores and Glucose Intolerance in Premenopausal Women: Role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism

Diabetes Care ◽  
2009 ◽  
Vol 32 (8) ◽  
pp. 1525-1530 ◽  
Author(s):  
M. A. Martinez-Garcia ◽  
M. Luque-Ramirez ◽  
J. L. San-Millan ◽  
H. F. Escobar-Morreale
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Glucose Intolerance ◽  
Iron Metabolism ◽  
Premenopausal Women ◽  
Body Iron ◽  
Genomic Variants ◽  
Iron Stores

Relationship between Increased Body Iron Stores, Oxidative Stress and Insulin Resistance in Healthy Men

2009 ◽  
Vol 54 (4) ◽  
pp. 268-274 ◽  
Author(s):  
Petr Syrovatka ◽  
Pavel Kraml ◽  
Jana Potockova ◽  
Lenka Fialova ◽  
Martin Vejrazka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Healthy Men ◽  
Body Iron ◽  
Iron Stores

Insulin Resistance and In Vivo Lipolytic Rate Are Positively Associated with Body Iron Stores in Obese Women

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2048-P
Author(s):  
BENJAMIN J. RYAN ◽  
DOUGLAS W. VAN PELT ◽  
LISA M. GUTH ◽  
ALISON LUDZKI ◽  
RACHEL A. GIOSCIA-RYAN ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Obese Women ◽  
Body Iron ◽  
Iron Stores

scholarly journals Caloric Restriction Reverses Hepatic Insulin Resistance and Steatosis in Rats with Low Aerobic Capacity

Endocrinology ◽  
2010 ◽  
Vol 151 (11) ◽  
pp. 5157-5164 ◽  
Author(s):  
Thomas A. Bowman ◽  
Sadeesh K. Ramakrishnan ◽  
Meenakshi Kaw ◽  
Sang Jun Lee ◽  
Payal R. Patel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Caloric Restriction ◽  
Visceral Obesity ◽  
Insulin Clearance ◽  
Hepatic Insulin Resistance ◽  
The Metabolic Syndrome ◽  
Cell Adhesion Molecule 1 ◽  
Muscle Triglyceride

Rats selectively bred for low aerobic running capacity exhibit the metabolic syndrome, including hyperinsulinemia, insulin resistance, visceral obesity, and dyslipidemia. They also exhibit features of nonalcoholic steatohepatitis, including chicken-wire fibrosis, inflammation, and oxidative stress. Hyperinsulinemia in these rats is associated with impaired hepatic insulin clearance. The current studies aimed to determine whether these metabolic abnormalities could be reversed by caloric restriction (CR). CR by 30% over a period of 2–3 months improved insulin clearance in parallel to inducing the protein content and activation of the carcinoembryonic antigen-related cell adhesion molecule 1, a main player in hepatic insulin extraction. It also reduced glucose and insulin intolerance and serum and tissue (liver and muscle) triglyceride levels. Additionally, CR reversed inflammation, oxidative stress, and fibrosis in liver. The data support a significant role of CR in the normalization of insulin and lipid metabolism in liver.

Distinct role of adiposity and insulin resistance in glucose intolerance: Studies in ventromedial hypothalamic-lesioned obese rats

Metabolism ◽  
2002 ◽  
Vol 51 (6) ◽  
pp. 716-723 ◽  
Author(s):  
Asako Kageyama ◽  
Tsutomu Hirano ◽  
Haruaki Kageyama ◽  
Toshimasa Osaka ◽  
Yoshio Namba ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Intolerance ◽  
Obese Rats ◽  
Distinct Role

Abstract 357: Hepatic ERK2 Suppresses Endoplasmic Reticulum Stress, Leading to Protection from Oxidative Stress and Endothelial Dysfunction

2013 ◽  
Vol 33 (suppl_1) ◽  
Author(s):  
Takehiko Kujiraoka ◽  
Yasushi Satoh ◽  
Makoto Ayaori ◽  
Yasunaga Shiraishi ◽  
Yuko Arai-Nakaya ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Endoplasmic Reticulum ◽  
Fatty Acid ◽  
Endothelial Dysfunction ◽  
Er Stress ◽  
Vascular Complications ◽  
Metabolic Remodeling ◽  
And Oxidative Stress

Background Insulin signaling comprises 2 major cascades, the IRS/PI3K/Akt and Ras/Raf/MEK/ERK pathways. Many studies on the tissue-specific effects of the former pathway had been conducted, however, the role of the latter cascade in tissue-specific insulin resistance had not been investigated. High glucose/fatty acid toxicity, inflammation and oxidative stress, all of which are associated with insulin resistance, can activate ERK. Liver plays a central role of metabolism and hepatosteatosis (HST) is associated with vascular diseases. The aim of this study is to elucidate the role of hepatic ERK2 in HST, metabolic remodeling and endothelial dysfunction. Methods Serum biomarkers of vascular complications in human were compared between subjects with and without HST diagnosed by echography for regular medical checkup. Next, we created liver-specific ERK2 knockout mice (LE2KO) and fed them with a high-fat/high-sucrose diet (HFHSD) for 20 weeks. The histological analysis, the expression of hepatic sarco/endoplasmic reticulum (ER) Ca 2+ -ATPase 2 (SERCA2) and glucose-tolerance/insulin-sensitivity (GT/IS) were tested. Vascular superoxide production and endothelial function were evaluated with dihydroethidium staining and isometric tension measurement of aorta. Results The presence of HST significantly increased HOMA-IR, an indicator of insulin resistance or atherosclerotic index in human. HFHSD-fed LE2KO revealed a marked exacerbation in HST and metabolic remodeling represented by the impairment of GT/IS, elevated serum free fatty acid and hyperhomocysteinemia without changes in body weight, blood pressure and serum cholesterol/triglyceride levels. In the HFHSD-fed LE2KO, mRNA and protein expressions of hepatic SERCA2 were significantly decreased, which resulted in hepatic ER stress. Induction of vascular superoxide production and remarkable endothelial dysfunction were also observed in them. Conclusions Hepatic ERK2 revealed the suppression of hepatic ER stress and HST in vivo , which resulted in protection from vascular oxidative stress and endothelial dysfunction. HST with hepatic ER stress can be a prominent risk of vascular complications by metabolic remodeling and oxidative stress in obese-related diseases.

scholarly journals Increased Body Iron Stores of Obese Women With Polycystic Ovary Syndrome Are a Consequence of Insulin Resistance and Hyperinsulinism and Are Not a Result of Reduced Menstrual Losses

Diabetes Care ◽  
2007 ◽  
Vol 30 (9) ◽  
pp. 2309-2313 ◽  
Author(s):  
M. Luque-Ramirez ◽  
F. Alvarez-Blasco ◽  
J. I. Botella-Carretero ◽  
R. Sanchon ◽  
J. L. San Millan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Body Iron ◽  
Iron Stores

scholarly journals Role of Supplementary Selenium on the Induction of Insulin Resistance and Oxidative Stress in NSY Mice Fed a High Fat Diet

2018 ◽  
Vol 41 (1) ◽  
pp. 92-98 ◽  
Author(s):  
Koichi Murano ◽  
Hirofumi Ogino ◽  
Tomofumi Okuno ◽  
Tomohiro Arakawa ◽  
Hitoshi Ueno
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
High Fat Diet ◽  
High Fat ◽  
And Oxidative Stress

Insulin Resistance, Oxidative Stress, and Podocyte Injury: Role of Rosuvastatin Modulation of Filtration Barrier Injury

2007 ◽  
Vol 28 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Adam Whaley-Connell ◽  
Vincent G. DeMarco ◽  
Guido Lastra ◽  
Camila Manrique ◽  
Ravi Nistala ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Podocyte Injury ◽  
Filtration Barrier
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