Relationship between Increased Body Iron Stores, Oxidative Stress and Insulin Resistance in Healthy Men

2009 ◽  
Vol 54 (4) ◽  
pp. 268-274 ◽  
Author(s):  
Petr Syrovatka ◽  
Pavel Kraml ◽  
Jana Potockova ◽  
Lenka Fialova ◽  
Martin Vejrazka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Healthy Men ◽  
Body Iron ◽  
Iron Stores

Insulin Resistance and In Vivo Lipolytic Rate Are Positively Associated with Body Iron Stores in Obese Women

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2048-P
Author(s):  
BENJAMIN J. RYAN ◽  
DOUGLAS W. VAN PELT ◽  
LISA M. GUTH ◽  
ALISON LUDZKI ◽  
RACHEL A. GIOSCIA-RYAN ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Obese Women ◽  
Body Iron ◽  
Iron Stores

scholarly journals Increased Body Iron Stores of Obese Women With Polycystic Ovary Syndrome Are a Consequence of Insulin Resistance and Hyperinsulinism and Are Not a Result of Reduced Menstrual Losses

Diabetes Care ◽  
2007 ◽  
Vol 30 (9) ◽  
pp. 2309-2313 ◽  
Author(s):  
M. Luque-Ramirez ◽  
F. Alvarez-Blasco ◽  
J. I. Botella-Carretero ◽  
R. Sanchon ◽  
J. L. San Millan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Body Iron ◽  
Iron Stores

scholarly journals Insulin resistance and adipose tissue inflammation induced by a high-fat diet are attenuated in the absence of hepcidin

2021 ◽  
Author(s):  
Jithu Varghese James ◽  
Joe Varghese ◽  
Nikhitha Mariya John ◽  
Jean Christophe Deschemin ◽  
Sophie Vaulont ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
High Fat Diet ◽  
Iron Homeostasis ◽  
Wild Type ◽  
High Fat ◽  
Knock Out ◽  
Body Iron ◽  
Iron Stores ◽  
Underlying Basis

Increased body iron stores and inflammation in adipose tissue have been implicated in the pathogenesis of insulin resistance (IR) and type 2 diabetes mellitus. However, the underlying basis of these associations are unclear. In order to assess this, we studied how IR and associated inflammation in adipose tissue developed in the presence of increased body iron stores. Male hepcidin knock-out (Hamp1-/-) mice, which have increased body iron stores, and wild-type (WT) mice were fed a high-fat diet (HFD) for 12 and 24 weeks. Development of IR and metabolic parameters linked to this, insulin signaling in tissue, and inflammation and iron-related parameters in visceral adipose tissue were studied in these animals. HFD-feeding resulted in impaired glucose tolerance in both genotypes of mice. In response to the HFD for 24 weeks, Hamp1-/- mice gained less body weight and developed less IR than corresponding WT mice. This was associated with less lipid accumulation in the liver and decreased inflammation and lipolysis in the adipose tissue in the knock-out mice, than in the WT animals. Fewer macrophages infiltrated the adipose tissue in the knockout mice than in wild-type mice, with these macrophages exhibiting a predominantly anti-inflammatory (M2-like) phenotype. These observations suggest a novel role of hepcidin (central regulator of systemic iron homeostasis) in the development of inflammation in adipose tissue and insulin resistance, in response to a high-fat diet.

scholarly journals Nordic walking training attenuation of oxidative stress in association with a drop in body iron stores in elderly women

2017 ◽  
Vol 18 (4) ◽  
pp. 517-524 ◽  
Author(s):  
Jakub Kortas ◽  
Agnieszka Kuchta ◽  
Krzysztof Prusik ◽  
Katarzyna Prusik ◽  
Ewa Ziemann ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Elderly Women ◽  
Nordic Walking ◽  
Body Iron ◽  
Iron Stores

scholarly journals Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men

2015 ◽  
Vol 7 (304) ◽  
pp. 304re7-304re7 ◽  
Author(s):  
Guenther Boden ◽  
Carol Homko ◽  
Carlos A. Barrero ◽  
T. Peter Stein ◽  
Xinhua Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Caloric Intake ◽  
Healthy Men

Body Iron Stores as Predictors of Insulin Resistance in Apparently Healthy Urban Colombian Men

2011 ◽  
Vol 145 (3) ◽  
pp. 283-285 ◽  
Author(s):  
Milton Fabian Suárez-Ortegón ◽  
Alejandra Arbeláez ◽  
Mildrey Mosquera ◽  
Fabián Méndez ◽  
Cecilia Aguilar-de Plata
Keyword(s):  
Insulin Resistance ◽  
Body Iron ◽  
Iron Stores ◽  
Apparently Healthy

Oxidative stress markers in women with polycystic ovary syndrome without insulin resistance

2018 ◽  
Author(s):  
Reveka Gyftaki ◽  
Sofia Gougoura ◽  
Nikolaos Kalogeris ◽  
Vasiliki Loi ◽  
George Koukoulis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Oxidative Stress Markers ◽  
Ovary Syndrome ◽  
Stress Markers
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