scholarly journals Insulin Resistance, Inflammation, and the Metabolic Syndrome Following Roux-en-Y Gastric Bypass Surgery in Severely Obese Subjects

Diabetes Care ◽  
2007 ◽  
Vol 30 (7) ◽  
pp. 1906-1908 ◽  
Author(s):  
R. Morinigo ◽  
R. Casamitjana ◽  
S. Delgado ◽  
A. Lacy ◽  
R. Deulofeu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
The Metabolic Syndrome ◽  
Severely Obese ◽  
Obese Subjects

A Model for Predicting the Resolution of Type 2 Diabetes in Severely Obese Subjects Following Roux-en Y Gastric Bypass Surgery

2011 ◽  
Vol 21 (7) ◽  
pp. 910-916 ◽  
Author(s):  
Mark Thomas Hayes ◽  
Lynette Anne Hunt ◽  
Jonathan Foo ◽  
Yulia Tychinskaya ◽  
Richard Strawson Stubbs
Keyword(s):  
Type 2 Diabetes ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Severely Obese ◽  
Obese Subjects

Roux-en Y Gastric Bypass Surgery Reduces Hedonic Hunger and Improves Dietary Habits in Severely Obese Subjects

2012 ◽  
Vol 23 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Jennifer Ullrich ◽  
Barbara Ernst ◽  
Britta Wilms ◽  
Martin Thurnheer ◽  
Bernd Schultes
Keyword(s):  
Gastric Bypass ◽  
Bypass Surgery ◽  
Dietary Habits ◽  
Gastric Bypass Surgery ◽  
Hedonic Hunger ◽  
Severely Obese ◽  
Obese Subjects

Loss of Insulin Resistance after Roux-en-Y Gastric Bypass Surgery: a Time Course Study

2005 ◽  
Vol 15 (4) ◽  
pp. 474-481 ◽  
Author(s):  
Kusal Wickremesekera ◽  
Geoff Miller ◽  
Tissa DeSilva Naotunne ◽  
Graham Knowles ◽  
Richard S. Stubbs
Keyword(s):  
Insulin Resistance ◽  
Gastric Bypass ◽  
Time Course ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Time Course Study

Long-Term Effects of Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Surgery on Type 2 Diabetes Mellitus in Morbidly Obese Subjects

2012 ◽  
Vol 256 (6) ◽  
pp. 1023-1029 ◽  
Author(s):  
Amanda Jiménez ◽  
Roser Casamitjana ◽  
Lílliam Flores ◽  
Judith Viaplana ◽  
Ricard Corcelles ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Long Term Effects ◽  
Obese Subjects

scholarly journals Liver markers, prevalence of the metabolic syndrome abnormalities and effect of Roux-en-Y gastric bypass in morbidly obese subjects

2011 ◽  
Vol 9 (4) ◽  
pp. 429-435
Author(s):  
Ary Serpa Neto ◽  
Felipe Martin Bianco Rossi ◽  
Rodrigo Dal Moro Amarante ◽  
Marçal Rossi
Keyword(s):  
Metabolic Syndrome ◽  
Gastric Bypass ◽  
Heavy Drinking ◽  
University Hospital ◽  
Morbidly Obese ◽  
Metabolic Abnormalities ◽  
Glucose Levels ◽  
The Metabolic Syndrome ◽  
Obese Subjects ◽  
Liver Markers

ABSTRACT Objectives: To evaluate the relations between liver markers (GGT, ALT and AST) and the metabolic syndrome (and its components) in morbidly obese subjects, and to determine the response of these metabolic factors and hepatic enzymes after weight loss induced by Roux-en-Y gastric bypass. Methods: This study was carried out at a university hospital, in Santo André (SP), Brazil. We evaluated 140 morbidly obese subjects aged from 18 to 60 years submitted to a Roux-en-Y gastric bypass, who were followed for a mean period of 8 months. Patients with a history of heavy drinking, type 1 diabetes, and/or liver disease were excluded. Results: Liver markers, most notably GGT, were strongly associated with metabolic abnormalities, mainly hyperglycemia. The prevalence of type 2 diabetes significantly increased with increasing levels of GGT (highest versus lowest quartile GGT: odds ratio 3.89 [95%CI: 1.07-14.17]). Liver markers significantly decreased 8 months after the Roux-en-Y gastric bypass and the reduction of GGT levels were associated with the reduction of glucose levels (Pearson r = 0.286; p = 0.001). Conclusions: Elevated levels of liver markers, principally GGT, in morbidly obese subjects are associated with metabolic abnormalities. In addition to the well-known benefits of bariatric surgery, Roux-en-Y gastric bypass, reduced the levels of liver markers to the normal range.

scholarly journals Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid

2018 ◽  
Vol 14 (8) ◽  
pp. 1126-1132 ◽  
Author(s):  
Prapimporn Chattranukulchai Shantavasinkul ◽  
Michael J. Muehlbauer ◽  
James R. Bain ◽  
Olga R. Ilkayeva ◽  
Damian M. Craig ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Hydroxybutyric Acid

scholarly journals Roux-en-Y-Bariatric Surgery Reduces Markers of Metabolic Syndrome in Morbidly Obese Patients

2019 ◽  
Vol 30 (2) ◽  
pp. 391-400 ◽  
Author(s):  
G. Rega-Kaun ◽  
C. Kaun ◽  
G. Jaegersberger ◽  
M. Prager ◽  
M. Hackl ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Metabolic Syndrome ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Diabetic Patients ◽  
Obese Patients ◽  
C Peptide ◽  
Hepatic Insulin Clearance

Abstract Background Obesity is closely linked to increased markers of metabolic syndrome and development of diabetes. Roux-en-Y bariatric surgery reduces hyperinsulinemia and improves insulin sensitivity and hence benefits morbidly obese patients. Aim To determine changes in markers of metabolic syndrome, pancreatic function, and hepatic insulin sensitivity in patients before and 1 year after undergoing Roux-en-Y gastric bypass surgery. Methods We enrolled 43 consecutive patients in a single center. Markers for metabolic syndrome included proinsulin, insulin, C-peptide, liver enzymes, and serum levels of selected microRNAs hsa-miR-122, hsa-miR-130, hsa-miR-132, and hsa-miR-375. Results After surgery, all patients showed a significant 37% drop of body mass index (p < 0.001). Furthermore, proinsulin (59% reduction, p < 0.001), insulin (76% reduction, p < 0.001), and C-peptide (56% reduction, p < 0.001) were all reduced 1 year after surgery. Using the hepatic insulin clearance score, we determined a significant increase in hepatic insulin clearance after surgery (76% increase, p < 0.001). Especially diabetic patients showed a marked 2.1-fold increase after surgery. Hepatic enzymes ALT (35% reduction, p = 0.002) and γGT (48% reduction, p < 0.001) were significantly reduced in all patients with similar improvement in diabetic and non-diabetic patients. miRNAs hsa-miR-122, hsa-miR-130, and hsa-miR-132 were all significantly reduced whereas hsa-miR-375 was increased after gastric bypass surgery (p < 0.001 for all miRNAs). Conclusion Both liver and pancreatic stress parameters were reduced significantly 1 year after Roux-en-Y gastric bypass surgery suggesting an overall amelioration of the metabolic syndrome in all patients regardless of previous health status.

scholarly journals Gastric Bypass Surgery in Severely Obese Type 1 Diabetic Patients

Diabetes Care ◽  
2004 ◽  
Vol 27 (10) ◽  
pp. 2561-2562 ◽  
Author(s):  
L. Czupryniak ◽  
J. Strzelczyk ◽  
K. Cypryk ◽  
M. Pawlowski ◽  
D. Szymanski ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Diabetic Patients ◽  
Severely Obese ◽  
Type 1 Diabetic Patients
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