scholarly journals Use of HbA1c in Predicting Progression to Diabetes in French Men and Women: Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)

Diabetes Care ◽  
2006 ◽  
Vol 29 (7) ◽  
pp. 1619-1625 ◽  
Author(s):  
C. Droumaguet ◽  
B. Balkau ◽  
D. Simon ◽  
E. Caces ◽  
J. Tichet ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Epidemiological Study ◽  
Insulin Resistance Syndrome ◽  
Men And Women

scholarly journals Predicting Diabetes: Clinical, Biological, and Genetic Approaches: Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)

Diabetes Care ◽  
2008 ◽  
Vol 31 (10) ◽  
pp. 2056-2061 ◽  
Author(s):  
B. Balkau ◽  
C. Lange ◽  
L. Fezeu ◽  
J. Tichet ◽  
B. de Lauzon-Guillain ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Epidemiological Study ◽  
Insulin Resistance Syndrome

scholarly journals Calcium consumption and insulin resistance syndrome parameters. Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)

2007 ◽  
Vol 17 (7) ◽  
pp. 486-492 ◽  
Author(s):  
Peggy Drouillet ◽  
Beverley Balkau ◽  
Marie Aline Charles ◽  
Sylviane Vol ◽  
Martine Bedouet ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Epidemiological Study ◽  
Insulin Resistance Syndrome

Lewis phenotypes and the insulin resistance syndrome in young healthy white men and women*

1995 ◽  
Vol 8 (11) ◽  
pp. 1060-1066 ◽  
Author(s):  
Jesper O. Clausen ◽  
Hans Ole Hein ◽  
Poul Suadicani ◽  
Kaj Winther ◽  
Finn Gyntelberg ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
White Men ◽  
Insulin Resistance Syndrome ◽  
Men And Women

Plasma Levels of Free and Total TFPI, Relationship with Cardiovascular Risk Factors and Endothelial Cell Markers

2001 ◽  
Vol 85 (06) ◽  
pp. 999-1003 ◽  
Author(s):  
P. E. Morange ◽  
J. F. Renucci ◽  
M. A. Charles ◽  
M. F. Aillaud ◽  
F. Giraud ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Cardiovascular Risk ◽  
Endothelial Cell ◽  
Cardiovascular Risk Factors ◽  
Plasma Levels ◽  
Anticoagulant Activity ◽  
Insulin Resistance Syndrome ◽  
Men And Women ◽  
Cell Markers

SummaryFree-TFPI (f-TFPI) presents high anticoagulant activity and its plasma level correlates with unfavorable outcomes in unstable angina. Total TFPI (t-TFPI) represents mainly the lipid-bound form which seems to have a poor anticoagulant activity. Until now, it is not known whether the variations of f-TFPI plasma levels are determined by environmental factors. The aim of our study was to evaluate the influence of cardiovascular risk factors on plasma levels of f-TFPI and relations with other endothelial derived molecules in a population of 626 patients (277 men and 349 women) attending a metabolic ward for primary prevention of coronary disease.Free and total TFPI plasma levels were poorly correlated. f-TFPI levels increased with age in both sexes, t-TFPI in women only. Ageadjusted correlations of TFPI levels with conventional cardiovascular risk factors and endothelial cell markers showed different patterns for f-TFPI and t-TFPI. f-TFPI correlated with parameters associated with insulin resistance, particularly in females. f-TFPI was also positively associated in both genders with fibrinogen and endothelial cell markers: t-PA, thrombomodulin (TM) and von Willebrand factor (vWF). t-TFPI correlated strongly with LDL-C in both sexes. It also correlated negatively with parameters of the insulin resistance syndrome. t-TFPI also correlated with TM but not with other endothelial cell markers. The results of the multivariate step by step analysis showed that cardiovascular risk factors poorly explained the f-TFPI variability (7% and 4% in men and women, respectively), whereas they explained 16 and 20% of t-TFPI variability in men and women respectively (mostly related to LDL-C).In conclusion, this study showed that free- and total-TFPI are regulated differently. f-TFPI strongly correlates with endothelial cell markers and t-TFPI is more related to conventional cardiovascular risk factors. The strong gender effect on f-TFPI levels remains to be explained.

Sign in / Sign up

Export Citation Format

Share Document