TCF7L2 Variation Predicts Hyperglycemia Incidence in a French General Population: The Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study

Diabetes ◽  
2006 ◽  
Vol 55 (11) ◽  
pp. 3189-3192 ◽  
Author(s):  
S. Cauchi ◽  
D. Meyre ◽  
H. Choquet ◽  
C. Dina ◽  
C. Born ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
General Population ◽  
Epidemiological Study ◽  
Insulin Resistance Syndrome

scholarly journals Predicting Diabetes: Clinical, Biological, and Genetic Approaches: Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)

Diabetes Care ◽  
2008 ◽  
Vol 31 (10) ◽  
pp. 2056-2061 ◽  
Author(s):  
B. Balkau ◽  
C. Lange ◽  
L. Fezeu ◽  
J. Tichet ◽  
B. de Lauzon-Guillain ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Epidemiological Study ◽  
Insulin Resistance Syndrome

scholarly journals Calcium consumption and insulin resistance syndrome parameters. Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)

2007 ◽  
Vol 17 (7) ◽  
pp. 486-492 ◽  
Author(s):  
Peggy Drouillet ◽  
Beverley Balkau ◽  
Marie Aline Charles ◽  
Sylviane Vol ◽  
Martine Bedouet ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Epidemiological Study ◽  
Insulin Resistance Syndrome

Plasma total adiponectin and changes in renal function in a cohort from the community: the prospective Data from an Epidemiological Study on the Insulin Resistance Syndrome study

2020 ◽  
Author(s):  
Frédéric Fumeron ◽  
Ray El Boustany ◽  
Jean-Philippe Bastard ◽  
Soraya Fellahi ◽  
Beverley Balkau ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Renal Function ◽  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
General Population ◽  
Kidney Function ◽  
Insulin Resistance Syndrome ◽  
Plasma Adiponectin ◽  
Kidney Function Decline

Abstract Background High adiponectin levels are associated with diabetic nephropathy. Nevertheless, it is not known whether plasma adiponectin is associated with renal function decline in the general population. We evaluated whether adiponectin concentrations were associated with changes in renal function in a community cohort, the Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study. Methods Plasma adiponectin concentrations were measured in a random sample of 3284 people from the DESIR study, a 9-year prospective cohort from the general population. Data were analysed for three endpoints during follow-up: incidence of Stage 3 chronic kidney disease (CKD); the Kidney Disease: Improving Global Outcomes (KDIGO) criterion ‘certain drop in eGFR’ and rapid kidney function decline [estimated glomerular filtration rate (eGFR) slope steeper than −3 mL/min/1.73 m2/year]. Results After exclusion of participants with an eGFR <60 mL/min/1.73 m2 at baseline and those with type 2 diabetes or impaired fasting glycaemia at any time during follow-up (remaining n = 2174), there was a 113% higher risk for a rapid decline in kidney function in participants with adiponectin above the third tertile (T3) versus below the first tertile (T1) (Ptrend = 0.004) and a 53% higher risk for kidney function decline as defined by the KDIGO criterion (Ptrend = 0.04). In a cross-sectional analysis, adiponectin was positively associated with urinary albumin:creatinine ratio at baseline (P = 0.009). Conclusions In a healthy cohort from the general population, higher levels of plasma adiponectin were associated with decreased renal function at baseline and at follow-up. This result is similar to what is observed in people with diabetic nephropathy, in contrast with animal models of nephropathy.

Sign in / Sign up

Export Citation Format

Share Document