A Single-Cell Transcriptomics Roadmap to Investigate Diabetes Remission Induced by the Central Action of Fibroblast Growth Factor-1 (FGF-1)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 375-OR
Author(s):  
MARIE A. BENTSEN ◽  
DYLAN RAUSCH ◽  
JARRAD SCARLETT ◽  
KIMBERLY M. ALONGE ◽  
PASCAL N. TIMSHEL ◽  
...  
Keyword(s):  
Growth Factor ◽  
Single Cell ◽  
Fibroblast Growth Factor ◽  
Diabetes Remission ◽  
Central Action ◽  
Fibroblast Growth

1800-P: Transcriptomic Evidence of a Role for Neuron-Glia Interactions in Diabetes Remission Induced by the Central Action of Fibroblast Growth Factor 1 (FGF-1)

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1800-P
Author(s):  
MARIE A. BENTSEN ◽  
DYLAN RAUSCH ◽  
ZAMAN MIRZADEH ◽  
JARRAD SCARLETT ◽  
JENNY M. BROWN ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Diabetes Remission ◽  
Central Action ◽  
Fibroblast Growth

scholarly journals Role of Hypothalamic MAPK/ERK Signaling in Diabetes Remission Induced by the Central Action of Fibroblast Growth Factor 1

2021 ◽  
Author(s):  
Jenny M. Brown ◽  
Marie A. Bentsen ◽  
Dylan M. Rausch ◽  
Bao Anh Phan ◽  
Danielle Wieck ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Diabetes Remission ◽  
Erk Signaling ◽  
Central Action ◽  
Fibroblast Growth

Sustained Diabetes Remission Induced by the Central Action of Fibroblast Growth Factor-1 (FGF-1) Requires Activation of Integrin Receptor aνß3

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 373-OR
Author(s):  
JARRAD SCARLETT ◽  
JENNY M. BROWN ◽  
BAO ANH N. PHAN ◽  
EDDIE L. KHAV ◽  
MILES E. MATSEN ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Diabetes Remission ◽  
Central Action ◽  
Fibroblast Growth ◽  
Integrin Receptor

214-OR: Role of Hypothalamic MAPK/ERK Signaling in Diabetes Remission Induced by the Central Action of Fibroblast Growth Factor 1 (FGF1)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 214-OR
Author(s):  
JENNY M. BROWN ◽  
BAO ANH N. PHAN ◽  
HUZAIFA WASANWALA ◽  
MILES E. MATSEN ◽  
ANNA SECHER ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Diabetes Remission ◽  
Erk Signaling ◽  
Central Action ◽  
Fibroblast Growth

Central action of basic fibroblast growth factor on ingestive behaviour in mice

1995 ◽  
Vol 57 (4) ◽  
pp. 747-752 ◽  
Author(s):  
D.A. Denton ◽  
J.R. Blair-West ◽  
M. McBurnie ◽  
R.S. Weisinger ◽  
A. Logan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Central Action ◽  
Fibroblast Growth ◽  
Ingestive Behaviour

scholarly journals Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats

2020 ◽  
Vol 2 (10) ◽  
pp. 1025-1033 ◽  
Author(s):  
Kimberly M. Alonge ◽  
Zaman Mirzadeh ◽  
Jarrad M. Scarlett ◽  
Aric F. Logsdon ◽  
Jenny M. Brown ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Diabetes Remission ◽  
Fibroblast Growth ◽  
Perineuronal Net

scholarly journals A Role for Fibroblast Growth Factor 19 and Bile Acids in Diabetes Remission After Roux-en-Y Gastric Bypass

Diabetes Care ◽  
2013 ◽  
Vol 36 (7) ◽  
pp. 1859-1864 ◽  
Author(s):  
G. S. Gerhard ◽  
A. M. Styer ◽  
G. C. Wood ◽  
S. L. Roesch ◽  
A. T. Petrick ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Growth Factor ◽  
Bile Acids ◽  
Fibroblast Growth Factor ◽  
Diabetes Remission ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor 19

scholarly journals The Hypothalamic Arcuate Nucleus–Median Eminence Is a Target for Sustained Diabetes Remission Induced by Fibroblast Growth Factor 1

Diabetes ◽  
2019 ◽  
Vol 68 (5) ◽  
pp. 1054-1061 ◽  
Author(s):  
Jenny M. Brown ◽  
Jarrad M. Scarlett ◽  
Miles E. Matsen ◽  
Hong T. Nguyen ◽  
Anna L. Secher ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Median Eminence ◽  
Arcuate Nucleus ◽  
Diabetes Remission ◽  
Fibroblast Growth ◽  
Hypothalamic Arcuate Nucleus

scholarly journals Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Marie A. Bentsen ◽  
Dylan M. Rausch ◽  
Zaman Mirzadeh ◽  
Kenjiro Muta ◽  
Jarrad M. Scarlett ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Cell Types ◽  
Diabetes Remission ◽  
Ependymal Cells ◽  
Sustained Remission ◽  
Fibroblast Growth ◽  
Transcriptional Responses ◽  
Wide Range ◽  
Melanocortin Signaling

Abstract In rodent models of type 2 diabetes (T2D), sustained remission of hyperglycemia can be induced by a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1), and the mediobasal hypothalamus (MBH) was recently implicated as the brain area responsible for this effect. To better understand the cellular response to FGF1 in the MBH, we sequenced >79,000 single-cell transcriptomes from the hypothalamus of diabetic Lepob/ob mice obtained on Days 1 and 5 after icv injection of either FGF1 or vehicle. A wide range of transcriptional responses to FGF1 was observed across diverse hypothalamic cell types, with glial cell types responding much more robustly than neurons at both time points. Tanycytes and ependymal cells were the most FGF1-responsive cell type at Day 1, but astrocytes and oligodendrocyte lineage cells subsequently became more responsive. Based on histochemical and ultrastructural evidence of enhanced cell-cell interactions between astrocytes and Agrp neurons (key components of the melanocortin system), we performed a series of studies showing that intact melanocortin signaling is required for the sustained antidiabetic action of FGF1. These data collectively suggest that hypothalamic glial cells are leading targets for the effects of FGF1 and that sustained diabetes remission is dependent on intact melanocortin signaling.

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