scholarly journals Role of Hypothalamic MAPK/ERK Signaling in Diabetes Remission Induced by the Central Action of Fibroblast Growth Factor 1

2021 ◽  
Author(s):  
Jenny M. Brown ◽  
Marie A. Bentsen ◽  
Dylan M. Rausch ◽  
Bao Anh Phan ◽  
Danielle Wieck ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Diabetes Remission ◽  
Erk Signaling ◽  
Central Action ◽  
Fibroblast Growth

214-OR: Role of Hypothalamic MAPK/ERK Signaling in Diabetes Remission Induced by the Central Action of Fibroblast Growth Factor 1 (FGF1)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 214-OR
Author(s):  
JENNY M. BROWN ◽  
BAO ANH N. PHAN ◽  
HUZAIFA WASANWALA ◽  
MILES E. MATSEN ◽  
ANNA SECHER ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Diabetes Remission ◽  
Erk Signaling ◽  
Central Action ◽  
Fibroblast Growth

scholarly journals Role of hypothalamic MAPK/ERK signaling in diabetes remission induced by the central action of fibroblast growth factor 1

2020 ◽  
Author(s):  
Jenny M. Brown ◽  
Marie A. Bentsen ◽  
Dylan M. Rausch ◽  
Bao Anh Phan ◽  
Danielle Wieck ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Diabetes Remission ◽  
Mitogen Activated Protein Kinase ◽  
Erk Signaling ◽  
Sustained Remission ◽  
Fibroblast Growth ◽  
Extracellular Signal ◽  
Mitogen Activated Protein

SummaryThe capacity of the brain to elicit sustained remission of hyperglycemia in rodent models of type 2 diabetes following intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) is well established. Here, we show that following icv FGF1 injection, hypothalamic signaling by extracellular signal-regulated kinases 1 and 2 (ERK1/2), members of the mitogen-activated protein kinase (MAPK) family is induced for at least 24h. Further, we show that in diabetic Lepob/ob mice, this prolonged response is required for the sustained antidiabetic action of FGF1, since it is abolished by sustained (but not acute) pharmacologic blockade of hypothalamic MAPK/ERK signaling. We also demonstrate that FGF1 R50E, a FGF1 mutant that activates FGF receptors but induces only transient hypothalamic MAPK/ERK signaling, fails to mimic the sustained glucose lowering induced by FGF1. These data identify sustained activation of hypothalamic MAPK/ERK signaling as playing an essential role in the mechanism underlying diabetes remission induced by icv FGF1 administration.

A Single-Cell Transcriptomics Roadmap to Investigate Diabetes Remission Induced by the Central Action of Fibroblast Growth Factor-1 (FGF-1)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 375-OR
Author(s):  
MARIE A. BENTSEN ◽  
DYLAN RAUSCH ◽  
JARRAD SCARLETT ◽  
KIMBERLY M. ALONGE ◽  
PASCAL N. TIMSHEL ◽  
...  
Keyword(s):  
Growth Factor ◽  
Single Cell ◽  
Fibroblast Growth Factor ◽  
Diabetes Remission ◽  
Central Action ◽  
Fibroblast Growth

1800-P: Transcriptomic Evidence of a Role for Neuron-Glia Interactions in Diabetes Remission Induced by the Central Action of Fibroblast Growth Factor 1 (FGF-1)

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1800-P
Author(s):  
MARIE A. BENTSEN ◽  
DYLAN RAUSCH ◽  
ZAMAN MIRZADEH ◽  
JARRAD SCARLETT ◽  
JENNY M. BROWN ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Diabetes Remission ◽  
Central Action ◽  
Fibroblast Growth

Sustained Diabetes Remission Induced by the Central Action of Fibroblast Growth Factor-1 (FGF-1) Requires Activation of Integrin Receptor aνß3

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 373-OR
Author(s):  
JARRAD SCARLETT ◽  
JENNY M. BROWN ◽  
BAO ANH N. PHAN ◽  
EDDIE L. KHAV ◽  
MILES E. MATSEN ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Diabetes Remission ◽  
Central Action ◽  
Fibroblast Growth ◽  
Integrin Receptor

The role of fibroblast growth factor-23 in left atrial volume

2013 ◽  
Vol 165 (5) ◽  
pp. e21 ◽  
Author(s):  
Supawat Ratanapo ◽  
Wonngarm Kittanamongkolchai ◽  
Narat Srivali ◽  
Saeed Ahmed ◽  
Wisit Cheungpasitporn ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Left Atrial ◽  
Fibroblast Growth Factor 23 ◽  
Left Atrial Volume ◽  
Fibroblast Growth ◽  
Atrial Volume
Sign in / Sign up

Export Citation Format

Share Document