scholarly journals Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Umbilical Cord Blood DNA Methylation, and Cardio-Metabolic Indicators in Newborns: The Healthy Start Study

2020 ◽  
Vol 128 (12) ◽  
pp. 127014
Author(s):  
Anne P. Starling ◽  
Cuining Liu ◽  
Guannan Shen ◽  
Ivana V. Yang ◽  
Katerina Kechris ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Prenatal Exposure ◽  
Umbilical Cord Blood ◽  
Healthy Start ◽  
Polyfluoroalkyl Substances

Associations between infant sex and DNA methylation across umbilical cord blood, artery, and placenta samples

Epigenetics ◽  
2021 ◽  
Author(s):  
Anne K. Bozack ◽  
Elena Colicino ◽  
Allan C. Just ◽  
Robert O. Wright ◽  
Andrea A. Baccarelli ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Infant Sex

Transcriptional Activity of Human Endogenous Retroviruses in Response to Prenatal Exposure of Maternal Cigarette Smoking

2018 ◽  
Vol 36 (10) ◽  
pp. 1060-1065 ◽  
Author(s):  
Massimiliano Bergallo ◽  
Ilaria Galliano ◽  
Valentina Daprà ◽  
Alice Pirra ◽  
Paola Montanari ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Tobacco Smoke ◽  
Transcriptional Activity ◽  
In Utero ◽  
Endogenous Retroviruses ◽  
Human Endogenous Retrovirus ◽  
Human Umbilical Cord

Objective Transcription of human endogenous retrovirus (HERV) elements is usually suppressed by epigenetic factors such as DNA methylation and heterochromatin silencing by histone modifications. There is an association between maternal smoking during pregnancy and DNA methylation levels in placental tissue and in DNA from cord blood. Study Design We assessed the transcriptional activity of HERV-H, HERV-K, and HERV-W in umbilical cord blood from 47 term babies unexposed to tobacco smoke in utero and 23 term babies exposed to tobacco smoke in utero. Results In our population, the HERV-H, HERV-K, and HERV-W families were always transcriptionally active, and the levels of all HERVs (H, K, W) were significantly higher in unexposed than smoke-exposed babies. Conclusion This study provides preliminary information about the transcriptional activity of HERV-H, HERV-K, and HERV-W families in human umbilical cord blood.

scholarly journals Umbilical Cord Blood DNA Methylation in Children Who Later Develop Type 1 Diabetes

2021 ◽  
Author(s):  
Essi Laajala ◽  
Ubaid Ullah ◽  
Toni Grönroos ◽  
Omid Rasool ◽  
Viivi Halla-aho ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Type 1 Diabetes ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Reduced Representation ◽  
Prediction And Prevention ◽  
Develop Type ◽  
Methylation Patterns

Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine, whether perinatal DNA methylation could be associated with later progression to type 1 diabetes. Reduced representation bisulfite sequencing (RRBS) analysis was performed on umbilical cord blood samples collected within the Type 1 Diabetes Prediction and Prevention (DIPP) study. Children later diagnosed with type 1 diabetes and/or testing positive for multiple islet autoantibodies (N=43) were compared to control individuals (N=79), who remained autoantibody-negative throughout the DIPP follow-up until 15 years of age. Potential confounding factors related to the pregnancy and the mother were included in the analysis. No differences in the cord blood methylation patterns were observed between these cases and controls.

scholarly journals Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth

Epigenetics ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. 1243-1258 ◽  
Author(s):  
Timothy P. York ◽  
Shawn J. Latendresse ◽  
Colleen Jackson-Cook ◽  
Dana M. Lapato ◽  
Sara Moyer ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Gestational Age ◽  
Gestational Age At Birth ◽  
Age At Birth

Umbilical cord blood PBDEs concentrations are associated with placental DNA methylation

2016 ◽  
Vol 97 ◽  
pp. 1-6 ◽  
Author(s):  
Yan Zhao ◽  
Pengcheng Liu ◽  
Junyong Wang ◽  
Xirong Xiao ◽  
Xiangzhou Meng ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood
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