Postmenopausal Women with Endometrial Cancer Have Greater Metabolic Dysfunction and Higher BMI than Women with Benign Endometrium

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 302-LB
Author(s):  
KATHERINE M. COOKE ◽  
ERICA DUN ◽  
ANIKA K. ANAM ◽  
CLARE FLANNERY
Keyword(s):  
Endometrial Cancer ◽  
Postmenopausal Women ◽  
Metabolic Dysfunction

Serum androgens and estrogens in postmenopausal women with and without endometrial cancer

1980 ◽  
Vol 136 (7) ◽  
pp. 859-866 ◽  
Author(s):  
Howard L. Judd ◽  
Bert J. Davidson ◽  
Anthony M. Frumar ◽  
Issa M. Shamonki ◽  
Leo D. Lagasse ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Postmenopausal Women ◽  
Serum Androgens

scholarly journals Serum Estrogens and Estrogen Metabolites and Endometrial Cancer Risk among Postmenopausal Women

2016 ◽  
Vol 25 (7) ◽  
pp. 1081-1089 ◽  
Author(s):  
Louise A. Brinton ◽  
Britton Trabert ◽  
Garnet L. Anderson ◽  
Roni T. Falk ◽  
Ashley S. Felix ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Estrogen Metabolites ◽  
Endometrial Cancer Risk

Abstract 2652: Metabolomics biomarkers for endometrial cancer and its recurrence after surgery in postmenopausal women

2018 ◽  
Author(s):  
Yannick Audet-Delage ◽  
Lyne Villeneuve ◽  
Jean Grégoire ◽  
Marie Plante ◽  
Chantal Guillemette
Keyword(s):  
Endometrial Cancer ◽  
Postmenopausal Women

scholarly journals Proliferation in Postmenopausal Endometrial Polyps—A Potential for Malignant Transformation

Medicina ◽  
2019 ◽  
Vol 55 (9) ◽  
pp. 543 ◽  
Author(s):  
Adomaitienė ◽  
Nadišauskienė ◽  
Nickkho-Amiry ◽  
Čižauskas ◽  
Palubinskienė ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Postmenopausal Women ◽  
Malignant Transformation ◽  
Hot Spot ◽  
Control Group ◽  
Ki 67 ◽  
Endometrial Polyps ◽  
Significant Difference ◽  
Immunohistochemical Studies ◽  
Asymptomatic Women

Background and objectives: Endometrial polyps in asymptomatic postmenopausal women are often incidentally found, yet only 1.51% of them are malignant. Their potential for malignant transformation has not been adequately addressed. The aim of this study was to investigate the proliferation within endometrial polyps as one of the indicators of their malignization potential in asymptomatic postmenopausal women. Materials and Methods: Immunohistochemical studies of Ki-67 were performed. Cases included 52 benign postmenopausal polyps, 19 endometrioid carcinoma with coexisting benign polyps, 12 polyps with foci of carcinoma and 4 cases of polyps, which later developed carcinoma. The control group included 31 atrophic endometria and 32 benign premenopausal polyps. Ki-67 was scored in either 10 or 20 “hot spot” fields, as percentage of positively stained cells. Results: The median epithelial Ki-67 score in postmenopausal benign polyps (4.7%) was significantly higher than in atrophic endometria (2.41%, p < 0.0001) and significantly lower than in premenopausal benign polyps (11.4%, p = 0.003) and endometrial cancer (8.3%, p < 0.0001). Where endometrial polyps were found in association with endometrial carcinoma, Ki-67 was significantly higher in cancer (p < 0.0001). No significant difference was found between Ki-67 scores of cancer focus and of the polyps tissue itself, respectively 2.8% and 4.55%, p = 0.37. Ki-67 expression, where polyps were resected and women later developed cancer, was not significantly different (p = 0.199). Conclusion: Polyps from asymptomatic postmenopausal women showed significantly more proliferation in both epithelial and stromal components than inactive atrophic endometria but less than premenopausal benign polyps and/or endometrial cancer. Benign postmenopausal endometrial polyps exhibit low proliferative activity, suggesting low malignant potential and may not require resection in asymptomatic women.

scholarly journals Estrogen replacement and skeletal muscle: mechanisms and population health

2013 ◽  
Vol 115 (5) ◽  
pp. 569-578 ◽  
Author(s):  
Peter M. Tiidus ◽  
Dawn A. Lowe ◽  
Marybeth Brown
Keyword(s):  
Skeletal Muscle ◽  
Postmenopausal Women ◽  
Muscle Mass ◽  
Enhanced Recovery ◽  
Rapid Onset ◽  
Metabolic Dysfunction ◽  
Skeletal Muscle Function ◽  
Strong Argument ◽  
Beneficial Effects ◽  
Health Related

There is a growing body of information supporting the beneficial effects of estrogen and estrogen-based hormone therapy (HT) on maintenance and enhancement of muscle mass, strength, and connective tissue. These effects are also evident in enhanced recovery from muscle atrophy or damage and have significant implications particularly for the muscular health of postmenopausal women. Evidence suggests that HT will also help maintain or increase muscle mass, improve postatrophy muscle recovery, and enhance muscle strength in aged females. This is important because this population, in particular, is at risk for a rapid onset of frailty. The potential benefits of estrogen and HT relative to skeletal muscle function and composition combined with other health-related enhancements associated with reduced risk of cardiovascular events, overall mortality, and metabolic dysfunction, as well as enhanced cognition and bone health cumulate in a strong argument for more widespread and prolonged consideration of HT if started proximal to menopausal onset in most women. Earlier reports of increased health risks with HT use in postmenopausal women has led to a decline in HT use. However, recent reevaluation regarding the health effects of HT indicates a general lack of risks and a number of significant health benefits of HT use when initiated at the onset of menopause. Although further research is still needed to fully delineate its mechanisms of action, the general use of HT by postmenopausal women, to enhance muscle mass and strength, as well as overall health, with initiation soon after the onset of menopause should be considered.

Endometrial Cancer in Postmenopausal Women Using Estradiol–Progestin Therapy

2009 ◽  
Vol 114 (6) ◽  
pp. 1197-1204 ◽  
Author(s):  
Susanna Jaakkola ◽  
Heli Lyytinen ◽  
Eero Pukkala ◽  
Olavi Ylikorkala
Keyword(s):  
Endometrial Cancer ◽  
Postmenopausal Women ◽  
Progestin Therapy
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