Sennoside A Improves Mitochondrial Function of Large Intestine in Diet-Induced Obese Mice to Preserve GLP-1 Expression through Induction of Short-Chain Fatty Acids

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1995-P
Author(s):  
JIAMEI LE ◽  
JIANPING YE ◽  
YONGNING SUN
Keyword(s):  
Fatty Acids ◽  
Large Intestine ◽  
Mitochondrial Function ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Obese Mice ◽  
Chain Fatty Acids

scholarly journals Short chain fatty acids in human large intestine, portal, hepatic and venous blood.

Gut ◽  
1987 ◽  
Vol 28 (10) ◽  
pp. 1221-1227 ◽  
Author(s):  
J H Cummings ◽  
E W Pomare ◽  
W J Branch ◽  
C P Naylor ◽  
G T Macfarlane
Keyword(s):  
Fatty Acids ◽  
Large Intestine ◽  
Venous Blood ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Human Large Intestine ◽  
Chain Fatty Acids

scholarly journals Weaning and the Weanling Diet Influence the Villous Height and Crypt Depth in the Small Intestine of Pigs and Alter the Concentrations of Short-Chain Fatty Acids in the Large Intestine and Blood

1998 ◽  
Vol 128 (6) ◽  
pp. 947-953 ◽  
Author(s):  
Hetty M. G. van Beers-Schreurs ◽  
Marius J. A. Nabuurs ◽  
Liebe Vellenga, ◽  
Hilda J. Kalsbeek-van der Valk ◽  
Theo Wensing ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Small Intestine ◽  
Large Intestine ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Crypt Depth ◽  
Villous Height ◽  
Chain Fatty Acids

scholarly journals MP33-09 GUT MICROBIOTA-DERIVED SHORT-CHAIN FATTY ACIDS PROMOTE PROSTATE CANCER GROWTH VIA IGF-1 SIGNALING IN OBESE MICE

2021 ◽  
Vol 206 (Supplement 3) ◽  
Author(s):  
Makoto Matsushita ◽  
Kazutoshi Fujita ◽  
Takuji Hayashi ◽  
Hisako Kayama ◽  
Daisuke Motooka ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Gut Microbiota ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Cancer Growth ◽  
Obese Mice ◽  
Chain Fatty Acids

scholarly journals Gut Microbiota and Host Metabolism: What Relationship

2017 ◽  
Vol 106 (4) ◽  
pp. 352-356 ◽  
Author(s):  
Gilles Mithieux
Keyword(s):  
Fatty Acids ◽  
Gut Microbiota ◽  
Metabolic Diseases ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Global Changes ◽  
Microbiota Composition ◽  
Obese Mice ◽  
Host Metabolism ◽  
Chain Fatty Acids

A large number of genomic studies have reported associations between the gut microbiota composition and metabolic diseases such as obesity or type 2 diabetes. This led to the widespread idea that a causal relationship could exist between intestinal microbiota and metabolic diseases. At odds with this idea, some compelling studies reported that global changes in microbiota composition have no effect on the host metabolism in obese mice or humans. However, specific bacteria are able to confer host metabolic benefits, such as Akkermansia muciniphila or Prevotella copri, when they are given by gavage in obese mice. A crucial link by which gut bacteria communicate with the host mucosa is based on metabolites or low-molecular-weight compounds. Among them, short-chain fatty acids produced from the fermentation of dietary fibers initiate beneficial effects on the host metabolism via the activation of intestinal gluconeogenesis (a mucosal function exerting antidiabetic and antiobesity effects through the activation of gut-brain neural circuits). However, fermentation of short-chain fatty acids is a function that is widespread among the main bacterial phyla and thus weakly depends on microbiota composition. Therefore, even if some bacteria may confer on the host metabolic benefits, the causal role of microbiota in metabolic diseases is not established.

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