scholarly journals Associations of Steroid Sex Hormones and Sex Hormone–Binding Globulin With the Risk of Type 2 Diabetes in Women: A Population-Based Cohort Study and Meta-analysis

Diabetes ◽  
2016 ◽  
Vol 66 (3) ◽  
pp. 577-586 ◽  
Author(s):  
Taulant Muka ◽  
Jana Nano ◽  
Loes Jaspers ◽  
Cindy Meun ◽  
Wichor M. Bramer ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Sex Hormones ◽  
Meta Analysis ◽  
Population Based ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Steroid Sex Hormones

Combined effects of sex hormone-binding globulin and sex hormones on risk of incident type 2 diabetes

2015 ◽  
Vol 8 (4) ◽  
pp. 508-515 ◽  
Author(s):  
Jinbo Hu ◽  
Aiping Zhang ◽  
Shumin Yang ◽  
Yue Wang ◽  
Richa Goswami ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Sex Hormones ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Combined Effects ◽  
Hormone Binding ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals The association of sex hormone-binding globulin with mortality is mediated by age and testosterone in men with type 2 diabetes

Andrology ◽  
2018 ◽  
Vol 6 (6) ◽  
pp. 846-853 ◽  
Author(s):  
S. Ramachandran ◽  
R. C. Strange ◽  
A. A. Fryer ◽  
F. Saad ◽  
G. I. Hackett
Keyword(s):  
Type 2 Diabetes ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

scholarly journals Low testosterone and sex hormone-binding globulin levels and high estradiol levels are independent predictors of type 2 diabetes in men

2010 ◽  
Vol 162 (4) ◽  
pp. 747-754 ◽  
Author(s):  
Torkel Vikan ◽  
Henrik Schirmer ◽  
Inger Njølstad ◽  
Johan Svartberg
Keyword(s):  
Type 2 Diabetes ◽  
Waist Circumference ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding ◽  
Adjusted Risk ◽  
The Third ◽  
Increased Risk

ObjectiveTo study the impact of endogenous sex hormone levels in community-dwelling men on later risk for type 2 diabetes.DesignPopulation-based prospective cohort study.MethodsFor the analyses, 1454 men who participated in the fourth Tromsø study (1994–1995) were used. Cases of diabetes were retrieved and validated until 31.12.05 following a detailed protocol. The prospective association between sex hormones and diabetes was examined using Cox proportional hazard regression analysis, allowing for multivariate adjustments.ResultsThere was a significantly lowered multi-adjusted risk for later diabetes with higher normal total testosterone levels, both linearly per s.d. increase (hazard ratio (HR) 0.71, confidence interval (CI) 0.54–0.92) and in the higher quartiles of total testosterone than in the lowest quartiles (HR 0.53, CI 0.33–0.84). A reduced multi-adjusted risk for incident diabetes was also found for men with higher sex hormone-binding globulin (SHBG) levels, both linearly per s.d. increase (HR 0.55, CI 0.39–0.79) and when comparing the third (HR 0.38, CI 0.18–0.81) and the fourth quartile (HR 0.37, CI 0.17–0.82) to the lowest quartile. The associations with total testosterone and SHBG were no longer significant after inclusion of waist circumference to the multivariate models. Estradiol (E2) was positively associated with incident diabetes after multivariate adjustments including waist circumference when comparing the second (HR 0.49, CI 0.26–0.93) and the third (HR 0.51, CI 0.27–0.96) quartile to the highest quartile.ConclusionMen with higher E2 levels had an increased risk of later diabetes independent of obesity, while men with lower total testosterone and SHBG had an increased risk of diabetes that appeared to be dependent on obesity.

scholarly journals Association of sex hormone-binding globulin and free testosterone with mortality in men with type 2 diabetes mellitus

2016 ◽  
Vol 174 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Aye N Tint ◽  
Rudolf Hoermann ◽  
Henry Wong ◽  
Elif I Ekinci ◽  
Richard J MacIsaac ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Inverse Association ◽  
Hormone Binding ◽  
All Cause Mortality

ObjectiveLow circulating testosterone levels have been associated with increased mortality in men. We hypothesized that the prognostic role of testosterone in men with type 2 diabetes mellitus (T2DM) is influenced by its carrier protein sex hormone-binding globulin (SHBG).DesignWe conducted a prospective cohort study at a tertiary referral centre.MethodsIn total, 531 men with T2DM presenting to a diabetes clinic in 2004–2005 were followed prospectively until death, or July 31, 2014, and a survival analysis was performed. The main outcome measure was all cause mortality.ResultsOver a mean (s.d.) follow up of 7.6 years (2.6) 175 men (33%) died. In Cox proportional hazard models both higher SHBG (Hazard Ratio (HR) 1.012 (95% CI 1.002–1.022), P=0.02) and lower calculated free testosterone (cFT) (HR 0.995 (95% CI 0.993–0.998), P=0.001) were risk factors for all cause mortality independently of age, BMI, presence of macro- and microvascular disease, duration of T2DM, hemoglobin, renal function, insulin use, C-reactive protein and homeostatic model of insulin resistance. By contrast, the inverse association of total testosterone (TT) with mortality weakened after these adjustments (P=0.11). SHBG remained associated with mortality (P<0.001) both if substituted for or added to TT in the multivariable model. In the fully adjusted model, an increase of SHBG by 17.3 nmol/l (1 s.d.) increased mortality by 22% and a decrease in cFT by 81 pmol/l (1 s.d.) increased mortality by 45%.ConclusionsThe association of SHBG with mortality in men with T2DM is novel. Whether SHBG acts via regulation of testosterone, has intrinsic biological roles, or is a marker of poor health requires further study.

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