scholarly journals Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes

Diabetes ◽  
2015 ◽  
Vol 64 (11) ◽  
pp. 3891-3902 ◽  
Author(s):  
Jennie H.M. Yang ◽  
Antony J. Cutler ◽  
Ricardo C. Ferreira ◽  
James L. Reading ◽  
Nicholas J. Cooper ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Natural Variation ◽  
Interleukin 2 ◽  
Cell Frequency ◽  
And Function

scholarly journals Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

PLoS Medicine ◽  
2016 ◽  
Vol 13 (10) ◽  
pp. e1002139 ◽  
Author(s):  
John A. Todd ◽  
Marina Evangelou ◽  
Antony J. Cutler ◽  
Marcin L. Pekalski ◽  
Neil M. Walker ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Single Dose ◽  
T Cell ◽  
Regulatory T Cell ◽  
Interleukin 2 ◽  
T Cell Responses ◽  
Dose Finding ◽  
Open Label ◽  
Cell Responses

scholarly journals Regulatory T cell phenotype and function 4 years after GAD-alum treatment in children with type 1 diabetes

2013 ◽  
Vol 172 (3) ◽  
pp. 394-402 ◽  
Author(s):  
M. Pihl ◽  
L. Åkerman ◽  
S. Axelsson ◽  
M. Chéramy ◽  
M. Hjorth ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Phenotype ◽  
Alum Treatment ◽  
And Function

scholarly journals Extracellular HMGB1 exacerbates autoimmune progression and recurrence of type 1 diabetes by impairing regulatory T cell stability

Diabetologia ◽  
2020 ◽  
Vol 63 (5) ◽  
pp. 987-1001
Author(s):  
Jing Zhang ◽  
Longmin Chen ◽  
Faxi Wang ◽  
Yuan Zou ◽  
Jingyi Li ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Stability

scholarly journals Reply to “Tolerogenic insulin peptide therapy precipitates type 1 diabetes”

2017 ◽  
Vol 214 (7) ◽  
pp. 2157-2159
Author(s):  
Carolin Daniel ◽  
Benno Weigmann ◽  
Harald von Boehmer
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Preventive Effect ◽  
Peptide Therapy ◽  
Cell Conversion

In this issue of JEM, Bergman et al. (https://doi.org/10.1084/jem.20160471) challenge the data published in our previous JEM paper on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Here, we provide a response to these data and suggest that appropriate subimmunogenic conditions are required to induce Foxp3+ regulatory T cell conversion.

scholarly journals A Mimic of Viral Double-Stranded RNA Triggers Fulminant Type 1 Diabetes-like Syndrome in Regulatory T Cell-Deficient Autoimmune Diabetic Mouse

2011 ◽  
Vol 187 (10) ◽  
pp. 4947-4953 ◽  
Author(s):  
Ai Tada ◽  
Akira Shimada ◽  
Taketo Yamada ◽  
Yoichi Oikawa ◽  
Yoshifumi Yamada ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Diabetic Mouse ◽  
Fulminant Type 1 Diabetes ◽  
Double Stranded Rna ◽  
Fulminant Type

Treatment of type 1 diabetes by regulatory T‐cell infusion via regulating the expression of inflammatory cytokines

2019 ◽  
Vol 120 (12) ◽  
pp. 19338-19344 ◽  
Author(s):  
Guofeng Wang ◽  
Yongxin Yan ◽  
Ning Xu ◽  
Dong Yin ◽  
Yuan Hui
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Inflammatory Cytokines ◽  
Regulatory T Cell
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