scholarly journals Regulatory T cell phenotype and function 4 years after GAD-alum treatment in children with type 1 diabetes

2013 ◽  
Vol 172 (3) ◽  
pp. 394-402 ◽  
Author(s):  
M. Pihl ◽  
L. Åkerman ◽  
S. Axelsson ◽  
M. Chéramy ◽  
M. Hjorth ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Phenotype ◽  
Alum Treatment ◽  
And Function

scholarly journals 1,25-Dihydroxyvitamin D3 and Its Analog TX527 Promote a Stable Regulatory T Cell Phenotype in T Cells from Type 1 Diabetes Patients

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e109194 ◽  
Author(s):  
Tom L. Van Belle ◽  
An-Sofie Vanherwegen ◽  
Dorien Feyaerts ◽  
Pierre De Clercq ◽  
Annemieke Verstuyf ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Phenotype ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Diabetes Patients

scholarly journals Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes

Diabetes ◽  
2015 ◽  
Vol 64 (11) ◽  
pp. 3891-3902 ◽  
Author(s):  
Jennie H.M. Yang ◽  
Antony J. Cutler ◽  
Ricardo C. Ferreira ◽  
James L. Reading ◽  
Nicholas J. Cooper ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Natural Variation ◽  
Interleukin 2 ◽  
Cell Frequency ◽  
And Function

scholarly journals Sex differences in autoimmunity could be associated with altered regulatory T cell phenotype and lipoprotein metabolism

2019 ◽  
Author(s):  
George A Robinson ◽  
Kirsty E Waddington ◽  
Marsilio Adriani ◽  
Anna Radziszewska ◽  
Hannah Peckham ◽  
...  
Keyword(s):  
Sex Differences ◽  
T Cell ◽  
Regulatory T Cell ◽  
Immune Cell ◽  
Pubertal Development ◽  
Cell Subset ◽  
Cell Phenotype ◽  
Healthy Adolescent ◽  
Treg Frequency ◽  
And Function

ABSTRACTMale and female immune responses are known to differ resulting in an increased prevalence of autoimmunity in women. Here sex differences in T-cell subset frequency and function during adolescence were examined in healthy donors and patients with the autoimmune disease juvenile (J)SLE; onset of JSLE commonly occurs during puberty suggesting a strong hormonal influence. Healthy adolescent males had increased regulatory T-cell (Treg) frequency, and increased Treg suppressive capacity and IL-4 production compared to healthy adolescent females. The T-helper 2-like profile in male Tregs was associated with increased expression of GATA3 which correlated significantly with elevated Treg plasma membrane glycosphingolipid expression. Differential Treg phenotype was associated with unique serum metabolomic profiles in males compared to female adolescents. Notably, very low density lipoprotein (VLDL) metabolomic signatures correlated positively with activated Tregs in males but with resting Tregs in females. Consistently, only VLDL isolated from male serum was able to induce increased Treg IL-4 production and glycosphingolipid expression following in cultured cells. Remarkably, gender differences in Treg frequency, phenotype and function and serum metabolomic profiles were lost in adolescents with JSLE. This work provides evidence that a combination of pubertal development, immune cell defects and dyslipidemia may contribute to JSLE pathogenesis.

scholarly journals Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

PLoS Medicine ◽  
2016 ◽  
Vol 13 (10) ◽  
pp. e1002139 ◽  
Author(s):  
John A. Todd ◽  
Marina Evangelou ◽  
Antony J. Cutler ◽  
Marcin L. Pekalski ◽  
Neil M. Walker ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Single Dose ◽  
T Cell ◽  
Regulatory T Cell ◽  
Interleukin 2 ◽  
T Cell Responses ◽  
Dose Finding ◽  
Open Label ◽  
Cell Responses

scholarly journals Extracellular HMGB1 exacerbates autoimmune progression and recurrence of type 1 diabetes by impairing regulatory T cell stability

Diabetologia ◽  
2020 ◽  
Vol 63 (5) ◽  
pp. 987-1001
Author(s):  
Jing Zhang ◽  
Longmin Chen ◽  
Faxi Wang ◽  
Yuan Zou ◽  
Jingyi Li ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Stability

scholarly journals Reply to “Tolerogenic insulin peptide therapy precipitates type 1 diabetes”

2017 ◽  
Vol 214 (7) ◽  
pp. 2157-2159
Author(s):  
Carolin Daniel ◽  
Benno Weigmann ◽  
Harald von Boehmer
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Preventive Effect ◽  
Peptide Therapy ◽  
Cell Conversion

In this issue of JEM, Bergman et al. (https://doi.org/10.1084/jem.20160471) challenge the data published in our previous JEM paper on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Here, we provide a response to these data and suggest that appropriate subimmunogenic conditions are required to induce Foxp3+ regulatory T cell conversion.

scholarly journals A Mimic of Viral Double-Stranded RNA Triggers Fulminant Type 1 Diabetes-like Syndrome in Regulatory T Cell-Deficient Autoimmune Diabetic Mouse

2011 ◽  
Vol 187 (10) ◽  
pp. 4947-4953 ◽  
Author(s):  
Ai Tada ◽  
Akira Shimada ◽  
Taketo Yamada ◽  
Yoichi Oikawa ◽  
Yoshifumi Yamada ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Diabetic Mouse ◽  
Fulminant Type 1 Diabetes ◽  
Double Stranded Rna ◽  
Fulminant Type

Treatment of type 1 diabetes by regulatory T‐cell infusion via regulating the expression of inflammatory cytokines

2019 ◽  
Vol 120 (12) ◽  
pp. 19338-19344 ◽  
Author(s):  
Guofeng Wang ◽  
Yongxin Yan ◽  
Ning Xu ◽  
Dong Yin ◽  
Yuan Hui
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Inflammatory Cytokines ◽  
Regulatory T Cell
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