scholarly journals White Matter Integrity Disruptions Associated With Cognitive Impairments in Type 2 Diabetic Patients

Diabetes ◽  
2014 ◽  
Vol 63 (11) ◽  
pp. 3596-3605 ◽  
Author(s):  
Junying Zhang ◽  
Yunxia Wang ◽  
Jun Wang ◽  
Xiaoqing Zhou ◽  
Ni Shu ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Impairments ◽  
White Matter Integrity ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Plasma NT-proBNP and white matter hyperintensities in type 2 diabetic patients

2012 ◽  
Vol 11 (1) ◽  
pp. 119 ◽  
Author(s):  
Henrik Reinhard ◽  
Ellen Garde ◽  
Arnold Skimminge ◽  
Per Åkeson ◽  
Thomas Ramsøy ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Effects of Metformin on the Cerebral Metabolic Changes in Type 2 Diabetic Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Yung-Cheng Huang ◽  
Chien-Chin Hsu ◽  
Wei-Che Lin ◽  
Tang-Kai Yin ◽  
Chi-Wei Huang ◽  
...  
Keyword(s):  
White Matter ◽  
Cerebral Metabolism ◽  
Statistical Parametric Mapping ◽  
Metabolic Changes ◽  
Parahippocampal Gyrus ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Fdg Uptake ◽  
Type 2 Diabetic

Metformin, a widely used antidiabetic drug, has numerous effects on human metabolism. Based on emerging cellular, animal, and epidemiological studies, we hypothesized that metformin leads to cerebral metabolic changes in diabetic patients. To explore metabolism-influenced foci of brain, we used 2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography for type 2 diabetic patients taking metformin (MET,n=18), withdrawing from metformin (wdMET,n=13), and not taking metformin (noMET,n=9). Compared with the noMET group, statistical parametric mapping showed that the MET group had clusters with significantly higher metabolism in right temporal, right frontal, and left occipital lobe white matter and lower metabolism in the left parahippocampal gyrus, left fusiform gyrus, and ventromedial prefrontal cortex. In volume of interest (VOI-) based group comparisons, the normalized FDG uptake values of both hypermetabolic and hypometabolic clusters were significantly different between groups. The VOI-based correlation analysis across the MET and wdMET groups showed a significant negative correlation between normalized FDG uptake values of hypermetabolic clusters and metformin withdrawal durations and a positive but nonsignificant correlation in the turn of hypometabolic clusters. Conclusively, metformin affects cerebral metabolism in some white matter and semantic memory related sites in patients with type 2 diabetes.

Micro-structural white matter abnormalities in type 2 diabetic patients: a DTI study using TBSS analysis

2016 ◽  
Vol 58 (12) ◽  
pp. 1209-1216 ◽  
Author(s):  
Xin Tan ◽  
Peng Fang ◽  
Jie An ◽  
Huan Lin ◽  
Yi Liang ◽  
...  
Keyword(s):  
White Matter ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
White Matter Abnormalities ◽  
Type 2 Diabetic

scholarly journals Sensorimotor and pain‐related alterations of the gray matter and white matter in Type 2 diabetic patients with peripheral neuropathy

2019 ◽  
Vol 41 (3) ◽  
pp. 710-725 ◽  
Author(s):  
Youming Zhang ◽  
Minli Qu ◽  
Xiaoping Yi ◽  
Pei Zhuo ◽  
Jingyi Tang ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
White Matter ◽  
Gray Matter ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic
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