scholarly journals Sensorimotor and pain‐related alterations of the gray matter and white matter in Type 2 diabetic patients with peripheral neuropathy

2019 ◽  
Vol 41 (3) ◽  
pp. 710-725 ◽  
Author(s):  
Youming Zhang ◽  
Minli Qu ◽  
Xiaoping Yi ◽  
Pei Zhuo ◽  
Jingyi Tang ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
White Matter ◽  
Gray Matter ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

577-P: Increased Symptoms of Peripheral Neuropathy and Depression in Insulin-Treated Type 2 Diabetic Patients Are Associated with Reduced BDNF Serum Protein Levels and Val66Met-SNP

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 577-P
Author(s):  
AMIR BASHKIN ◽  
AKRAM SAFADI ◽  
BELLA GROSS ◽  
NETANEL A. HOROWITZ ◽  
RIVKA SHARON ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Serum Protein ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Protein Levels ◽  
Type 2 Diabetic

scholarly journals White Matter Integrity Disruptions Associated With Cognitive Impairments in Type 2 Diabetic Patients

Diabetes ◽  
2014 ◽  
Vol 63 (11) ◽  
pp. 3596-3605 ◽  
Author(s):  
Junying Zhang ◽  
Yunxia Wang ◽  
Jun Wang ◽  
Xiaoqing Zhou ◽  
Ni Shu ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Impairments ◽  
White Matter Integrity ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Plasma NT-proBNP and white matter hyperintensities in type 2 diabetic patients

2012 ◽  
Vol 11 (1) ◽  
pp. 119 ◽  
Author(s):  
Henrik Reinhard ◽  
Ellen Garde ◽  
Arnold Skimminge ◽  
Per Åkeson ◽  
Thomas Ramsøy ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Comparison of Cross Sectional Areas of Median Nerve in Type 2 Diabetic Patients with Peripheral Neuropathy with Healthy Adult Subjects Measured by 2 D-B Mode High Resolution Ultrasonography

2017 ◽  
Vol 8 (1) ◽  
pp. 47-51
Author(s):  
Md Towhidur Rahman ◽  
AS Mohiuddin ◽  
Md Mofazzal Sharif ◽  
Jafreen Sultana ◽  
Fahmida Yeshmine ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Median Nerve ◽  
Healthy Adult ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
The Mean ◽  
The Difference ◽  
Type 2 Diabetic

Background: Patients with diabetic peripheral neuropathy (DPN) have distal, symmetrical form of the disorder characterized by numbness, burning feet, pins-and-needles sensations and lightning pain. This study was designed to find out the difference between 2 Dimentional (D)-Brightness (B) mode high resolution ultrasonographically measured cross sectional areas of median nerve in type 2 diabetic patients with peripheral neuropathy and those of non-diabetic healthy adult subjects.Methods: This case-control study was done on 180 subjects aged 27-67 years in the department of Radiology and Imaging, BIRDEM from January 2012 to December 2013. Out of them 90 diabetic patients with peripheral neuropathy diagnosed electrophysiologically by nerve conduction study (NCS) were considered study group and age, sex and weight compatible 90 healthy subjects were considered as control group. Measurement of cross sectional areas of median nerve was performed first by the investigator himself purposefully, consecutively and subsequently confirmed by a radiologist in the department of Radiology and Imaging, BIRDEM, who did not know the subjects’ condition to eliminate bias. The major axis, minor axis and the cross sectional areas (CSA) of the median nerve were measured at the carpal tunnel.Results: In this study, the mean cross sectional areas (mm2) of median nerve healthy subjects was 7.78±1.00 mm2 and in diabetic patients with peripheral neuropathy was 13.67±2.97 mm2. The difference mean CSA of median nerve of diabetic subjects with peripheral neuropathy and control subjects were statistically significant (p<0.05) in unpaired ‘t’ test.Conclusion: This study showed that there is a significant difference between the cross sectional areas of median nerve in diabetic subjects with peripheral neuropathy and healthy adult subjects. The mean cross sectional areas of median nerve were increased in diabetic patients with peripheral neuropathy compared to control group.Birdem Med J 2018; 8(1): 47-51

scholarly journals Effects of Metformin on the Cerebral Metabolic Changes in Type 2 Diabetic Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Yung-Cheng Huang ◽  
Chien-Chin Hsu ◽  
Wei-Che Lin ◽  
Tang-Kai Yin ◽  
Chi-Wei Huang ◽  
...  
Keyword(s):  
White Matter ◽  
Cerebral Metabolism ◽  
Statistical Parametric Mapping ◽  
Metabolic Changes ◽  
Parahippocampal Gyrus ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Fdg Uptake ◽  
Type 2 Diabetic

Metformin, a widely used antidiabetic drug, has numerous effects on human metabolism. Based on emerging cellular, animal, and epidemiological studies, we hypothesized that metformin leads to cerebral metabolic changes in diabetic patients. To explore metabolism-influenced foci of brain, we used 2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography for type 2 diabetic patients taking metformin (MET,n=18), withdrawing from metformin (wdMET,n=13), and not taking metformin (noMET,n=9). Compared with the noMET group, statistical parametric mapping showed that the MET group had clusters with significantly higher metabolism in right temporal, right frontal, and left occipital lobe white matter and lower metabolism in the left parahippocampal gyrus, left fusiform gyrus, and ventromedial prefrontal cortex. In volume of interest (VOI-) based group comparisons, the normalized FDG uptake values of both hypermetabolic and hypometabolic clusters were significantly different between groups. The VOI-based correlation analysis across the MET and wdMET groups showed a significant negative correlation between normalized FDG uptake values of hypermetabolic clusters and metformin withdrawal durations and a positive but nonsignificant correlation in the turn of hypometabolic clusters. Conclusively, metformin affects cerebral metabolism in some white matter and semantic memory related sites in patients with type 2 diabetes.

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