scholarly journals Early Detection of Nerve Fiber Loss by Corneal Confocal Microscopy and Skin Biopsy in Recently Diagnosed Type 2 Diabetes

Diabetes ◽  
2014 ◽  
Vol 63 (7) ◽  
pp. 2454-2463 ◽  
Author(s):  
D. Ziegler ◽  
N. Papanas ◽  
A. Zhivov ◽  
S. Allgeier ◽  
K. Winter ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Confocal Microscopy ◽  
Early Detection ◽  
Skin Biopsy ◽  
Nerve Fiber ◽  
Corneal Confocal Microscopy

scholarly journals Small Nerve Fiber Damage and Langerhans Cells in Type 1 and Type 2 Diabetes and LADA Measured by Corneal Confocal Microscopy

2021 ◽  
Vol 62 (6) ◽  
pp. 5
Author(s):  
Luca D'Onofrio ◽  
Alise Kalteniece ◽  
Maryam Ferdousi ◽  
Shazli Azmi ◽  
Ioannis N. Petropoulos ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Confocal Microscopy ◽  
Nerve Fiber ◽  
Langerhans Cells ◽  
Fiber Damage ◽  
Corneal Confocal Microscopy ◽  
Small Nerve

scholarly journals Corneal Confocal Microscopy in the Diagnosis of Small Fiber Neuropathy: Faster, Easier, and More Efficient Than Skin Biopsy?

2021 ◽  
Vol 29 (1) ◽  
pp. 1-8
Author(s):  
Mariia V. Lukashenko ◽  
Natalia Y. Gavrilova ◽  
Anna V. Bregovskaya ◽  
Lidiia A. Soprun ◽  
Leonid P. Churilov ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Skin Biopsy ◽  
Nerve Fiber ◽  
Small Fiber Neuropathy ◽  
Fiber Damage ◽  
Advantages And Disadvantages ◽  
Small Fiber ◽  
Corneal Confocal Microscopy ◽  
Common Causes ◽  
Small Nerve

Chronic pain may affect 30–50% of the world’s population and an important cause is small fiber neuropathy (SFN). Recent research suggests that autoimmune diseases may be one of the most common causes of small nerve fiber damage. There is low awareness of SFN among patients and clinicians and it is difficult to diagnose as routine electrophysiological methods only detect large fiber abnormalities, and specialized small fiber tests, like skin biopsy and quantitative sensory testing, are not routinely available. Corneal confocal microscopy (CCM) is a rapid, non-invasive, reproducible method for quantifying small nerve fiber degeneration and regeneration, and could be an important tool for diagnosing SFN. This review considers the advantages and disadvantages of CCM and highlights the evolution of this technique from a research tool to a diagnostic test for small fiber damage, which can be a valuable contribution to the study and management of autoimmune disease.

Corneal confocal microscopy as a tool for detecting diabetic polyneuropathy in a cohort with screen-detected type 2 diabetes: ADDITION-Denmark

2018 ◽  
Vol 32 (12) ◽  
pp. 1153-1159 ◽  
Author(s):  
Signe T. Andersen ◽  
Kasper Grosen ◽  
Hatice Tankisi ◽  
Morten Charles ◽  
Niels T. Andersen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Confocal Microscopy ◽  
Diabetic Polyneuropathy ◽  
Corneal Confocal Microscopy

scholarly journals Corneal Confocal Microscopy Identifies Small-Fiber Neuropathy in Subjects With Impaired Glucose Tolerance Who Develop Type 2 Diabetes

Diabetes Care ◽  
2015 ◽  
Vol 38 (8) ◽  
pp. 1502-1508 ◽  
Author(s):  
Shazli Azmi ◽  
Maryam Ferdousi ◽  
Ioannis N. Petropoulos ◽  
Georgios Ponirakis ◽  
Uazman Alam ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Confocal Microscopy ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Small Fiber Neuropathy ◽  
Small Fiber ◽  
Corneal Confocal Microscopy ◽  
Develop Type

scholarly journals Diagnosis of Neuropathy and Risk Factors for Corneal Nerve Loss in Type 1 and Type 2 Diabetes: A Corneal Confocal Microscopy Study

Diabetes Care ◽  
2020 ◽  
Vol 44 (1) ◽  
pp. 150-156
Author(s):  
Maryam Ferdousi ◽  
Alise Kalteniece ◽  
Shazli Azmi ◽  
Ioannis N. Petropoulos ◽  
Georgios Ponirakis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Confocal Microscopy ◽  
Microscopy Study ◽  
Corneal Confocal Microscopy ◽  
Corneal Nerve

Relationship between corneal confocal microscopy and markers of peripheral nerve structure and function in Type 2 diabetes

2019 ◽  
Vol 37 (2) ◽  
pp. 326-334 ◽  
Author(s):  
A. Yan ◽  
T. Issar ◽  
S. S. Tummanapalli ◽  
M. Markoulli ◽  
N. C. G. Kwai ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Confocal Microscopy ◽  
Peripheral Nerve ◽  
Structure And Function ◽  
Nerve Structure ◽  
Corneal Confocal Microscopy ◽  
And Function

scholarly journals In vivo corneal confocal microscopy and optical coherence tomography on eyes of participants with type 2 diabetes mellitus and obese participants without diabetes

2021 ◽  
Author(s):  
Noémi Tóth ◽  
David M. Silver ◽  
Szabolcs Balla ◽  
Miklós Káplár ◽  
Adrienne Csutak
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Optical Coherence Tomography ◽  
Type 2 Diabetes Mellitus ◽  
Confocal Microscopy ◽  
Nerve Fibers ◽  
Corneal Confocal Microscopy ◽  
Corneal Nerve

Abstract Purposes To examine corneal nerve and retinal nerve characteristics of participants with type 2 diabetes mellitus (T2DM) compared with obese participants without diabetes to discover potential nerve vulnerabilities. Methods All participants underwent a complete medical examination including a physical examination and blood sample tests. The ophthalmologic examination included best-corrected visual acuity, intraocular pressure, Schirmer test, tear film breakup time, slit-lamp examination, dilated fundus photography, in vivo corneal confocal microscopy (IVCCM), and optical coherence tomography (OCT). Results The study cohort consisted of 83 eyes of 83 individuals: a group of 44 participants with T2DM, and a control group of 39 obese participants with no history of diabetes. Comparing measurements on the two groups, participants with T2DM had lower values with statistical significance for retinal nerve fiber layer (RNFL) nasal superior thickness (p = 0.010) and three corneal nerve (CN) parameters: fiber length (p = 0.025), total branch density (p = 0.013), and fiber area (p = 0.009). There was a borderline significant difference in CN fiber width (p = 0.051) and RNFL nasal inferior thickness (p = 0.056). No other significant differences were observed in the IVCCM and OCT parameters. No statistically significant correlation was found between CN and RNFL parameters. Conclusions Progression from a pre-diabetic obese state to a T2DM condition might entail a loss or diminishment of certain corneal nerve fibers or retinal nerve fibers, but not necessarily a loss of both corneal and retinal nerve fibers simultaneously. Using IVCCM and OCT together enables monitoring of both corneal and retinal health of the eye.

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