scholarly journals A New Home for Pancreatic Islet Transplants: The Bone Marrow

Diabetes ◽  
2013 ◽  
Vol 62 (10) ◽  
pp. 3333-3335 ◽  
Author(s):  
A. Pileggi ◽  
C. Ricordi
Keyword(s):  
Bone Marrow ◽  
Pancreatic Islet ◽  
Islet Transplants

Promotion of pancreatic islet allograft survival by intrathymic transplantation of bone marrow

Diabetes ◽  
1992 ◽  
Vol 41 (6) ◽  
pp. 771-775 ◽  
Author(s):  
A. M. Posselt ◽  
J. S. Odorico ◽  
C. F. Barker ◽  
A. Naji
Keyword(s):  
Bone Marrow ◽  
Pancreatic Islet ◽  
Allograft Survival ◽  
Islet Allograft ◽  
Pancreatic Islet Allograft

scholarly journals Autologous Pancreatic Islet Transplantation in Human Bone Marrow. Diabetes 2013;62:3523-3531

Diabetes ◽  
2013 ◽  
Vol 63 (1) ◽  
pp. 377-377
Author(s):  
P. Maffi ◽  
G. Balzano ◽  
M. Ponzoni ◽  
R. Nano ◽  
V. Sordi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Pancreatic Islet Transplantation

The Bone Marrow as a Potential Receptor Site for Pancreatic Islet Grafts

2008 ◽  
Vol 39 (1) ◽  
pp. 139-141 ◽  
Author(s):  
Anastasio Salazar-Bañuelos ◽  
James Wright ◽  
David Sigalet ◽  
Luis Benítez-Bribiesca
Keyword(s):  
Bone Marrow ◽  
Pancreatic Islet ◽  
Receptor Site

scholarly journals Factors Influencing Quantification of in Vivo Bioluminescence Imaging: Application to Assessment of Pancreatic Islet Transplants

2004 ◽  
Vol 3 (4) ◽  
pp. 153535002004041 ◽  
Author(s):  
John Virostko ◽  
Zhongyi Chen ◽  
Michael Fowler ◽  
Greg Poffenberger ◽  
Alvin C. Powers ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Bioluminescence Imaging ◽  
Factors Influencing ◽  
Imaging Application ◽  
In Vivo Bioluminescence Imaging ◽  
Islet Transplants

scholarly journals Culture on a native bone marrow‐derived extracellular matrix restores the pancreatic islet basement membrane, preserves islet function, and attenuates islet immunogenicity

2020 ◽  
Vol 34 (6) ◽  
pp. 8044-8056
Author(s):  
Hanzhou Wang ◽  
Shengxian Li ◽  
Qiuxia Dai ◽  
Aaron Gonzalez ◽  
Olivia N. Tran ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Extracellular Matrix ◽  
Basement Membrane ◽  
Pancreatic Islet ◽  
Islet Function ◽  
Native Bone

scholarly journals Differentiation of mesenchymal stem cells derived from human bone marrow and subcutaneous adipose tissue into pancreatic islet-like clusters in vitro

2013 ◽  
Vol 18 (1) ◽  
Author(s):  
Dhanasekaran Marappagounder ◽  
Indumathi Somasundaram ◽  
Sudarsanam Dorairaj ◽  
Rajkumar Sankaran
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Pancreatic Islet ◽  
Subcutaneous Adipose Tissue ◽  
Lineage Differentiation ◽  
Wide Range ◽  
Subcutaneous Adipose

AbstractAlthough stem cells are present in various adult tissues and body fluids, bone marrow has been the most popular source of stem cells for treatment of a wide range of diseases. Recent results for stem cells from adipose tissue have put it in a position to compete for being the leading therapeutic source. The major advantage of these stem cells over their counterparts is their amazing proliferative and differentiation potency. However, their pancreatic lineage transdifferentiation competence was not compared to that for bone marrow-derived stem cells. This study aims to identify an efficient source for transdifferentiation into pancreatic islet-like clusters, which would increase potential application in curative diabetic therapy. The results reveal that mesenchymal stem cells (MSC) derived from bone marrow and subcutaneous adipose tissue can differentiate into pancreatic islet-like clusters, as evidenced by their islet-like morphology, positive dithizone staining and expression of genes such as Nestin, PDX1, Isl 1, Ngn 3, Pax 4 and Insulin. The pancreatic lineage differentiation was further corroborated by positive results in the glucose challenge assay. However, the results indicate that bone marrow-derived MSCs are superior to those from subcutaneous adipose tissue in terms of differentiation into pancreatic islet-like clusters. In conclusion, bone marrow-derived MSC might serve as a better alternative in the treatment of diabetes mellitus than those from adipose tissue.

Peripheral mobilization of recipient bone marrow-derived endothelial progenitor cells enhances pancreatic islet revascularization and engraftment after intraportal transplantation

Surgery ◽  
2003 ◽  
Vol 134 (2) ◽  
pp. 390-398 ◽  
Author(s):  
Juan L. Contreras ◽  
Cheryl A. Smyth ◽  
Christopher Eckstein ◽  
Guadalupe Bilbao ◽  
J.Anthony Thompson ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Pancreatic Islet ◽  
Endothelial Progenitor

scholarly journals Multilayered nanocoatings incorporating superparamagnetic nanoparticles for tracking of pancreatic islet transplants with magnetic resonance imaging

2013 ◽  
Vol 49 (65) ◽  
pp. 7255 ◽  
Author(s):  
Yang Wang ◽  
Cristina Blanco-Andujar ◽  
Zheng-liang Zhi ◽  
Po-Wah So ◽  
Nguyen Thi Kim Thanh ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Pancreatic Islet ◽  
Superparamagnetic Nanoparticles ◽  
Resonance Imaging ◽  
Islet Transplants
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