scholarly journals Contribution of Common Genetic Variation to the Risk of Type 2 Diabetes in the Mexican Mestizo Population

Diabetes ◽  
2012 ◽  
Vol 61 (12) ◽  
pp. 3314-3321 ◽  
Author(s):  
M. A. Gamboa-Melendez ◽  
A. Huerta-Chagoya ◽  
H. Moreno-Macias ◽  
P. Vazquez-Cardenas ◽  
M. L. Ordonez-Sanchez ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variation ◽  
Common Genetic Variation ◽  
Mexican Mestizo ◽  
Mexican Mestizo Population

scholarly journals Evolution of type 2 diabetes and carbohydrate intolerance following bariatric surgery in a Mexican mestizo population

2017 ◽  
Vol 85 (2) ◽  
pp. 135-142
Author(s):  
Eva Ramírez-Avilés ◽  
Omar Espinosa-González ◽  
Mónica Amado-Galván ◽  
Hernán Maydón-González ◽  
Elisa Sepúlveda-Guerrero ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Mexican Mestizo ◽  
Carbohydrate Intolerance ◽  
Mexican Mestizo Population

scholarly journals Identification of genetic variants in pharmacogenetic genes associated with type 2 diabetes in a Mexican-Mestizo population

2017 ◽  
Vol 7 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Nidia Samara Rodríguez-Rivera ◽  
Patricia Cuautle-Rodríguez ◽  
Fernando Castillo-Nájera ◽  
Juan Arcadio Molina-Guarneros
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variants ◽  
Mexican Mestizo ◽  
Mexican Mestizo Population

scholarly journals Association of Common Genetic Variation in TheFOXO1Gene with β-Cell Dysfunction, Impaired Glucose Tolerance, And Type 2 Diabetes

2009 ◽  
Vol 23 (2) ◽  
pp. 278-279
Author(s):  
Karsten Müssig ◽  
Harald Staiger ◽  
Fausto Machicao ◽  
Alena Stančáková ◽  
Johanna Kuusisto ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variation ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Common Genetic Variation ◽  
Β Cell ◽  
Cell Dysfunction

Pharmacogenetic Evaluation of Metformin and Sulphonylurea Response in Mexican Mestizos with Type 2 Diabetes

2020 ◽  
Vol 21 (4) ◽  
pp. 291-300
Author(s):  
Menjivar Marta ◽  
Katy Sánchez-Pozos ◽  
Joel Jaimes-Santoyo ◽  
Jazmin Monroy-Escutia ◽  
Carolina Rivera- Santiago ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Mexican Mestizo ◽  
Significant Difference ◽  
Clinical Consequences ◽  
Mexican Mestizos ◽  
Oral Hypoglycemic Drugs ◽  
The Impact ◽  
Mexican Mestizo Population

Background: In Mexico, approximately 25% of patients with type 2 diabetes (T2D) have adequate glycemic control. Polymorphisms in pharmacogenetic genes have been shown to have clinical consequences resulting in drug toxicity or therapeutic inefficacy. Objective: The study aimed to evaluate the impact of variants in genes known to be involved in response to oral hypoglycemic drugs, such as CYP2C9, OCT, MATE, ABCA1 and C11orf65, in the Mexican Mestizo population of T2D patients. Methods: In this study, 265 patients with T2D were enrolled from the Hospital Juárez de México, Mexico City. Genotyping was performed by TaqMan® assays. SNP-SNP interactions were analyzed using the multifactor dimensionality reduction (MDR) method. Results: Carriers of the del allele of rs72552763 could achieve better glycemic control than noncarriers. There was a significant difference in plasma glucose and HbA1c levels among rs622342 genotypes. The results suggested an SNP-SNP interaction between rs72552763 and rs622342 OCT1 and rs12943590 MATE2. Conclusion: The interaction between rs72552763 and rs622342 in OCT1, and rs12943590 in MATE2 suggested an important role of these polymorphisms in metformin response in T2D Mexican Mestizo population.

scholarly journals Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure

Diabetologia ◽  
2014 ◽  
Vol 57 (7) ◽  
pp. 1382-1390 ◽  
Author(s):  
Yunhua L. Muller ◽  
Paolo Piaggi ◽  
Duncan Hoffman ◽  
Ke Huang ◽  
Brittany Gene ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variation ◽  
Energy Expenditure ◽  
Carbohydrate Oxidation ◽  
Common Genetic Variation ◽  
Glucokinase Gene

scholarly journals Association of Common Genetic Variation in theFOXO1Gene with β-Cell Dysfunction, Impaired Glucose Tolerance, and Type 2 Diabetes

2009 ◽  
Vol 94 (4) ◽  
pp. 1353-1360 ◽  
Author(s):  
Karsten Müssig ◽  
Harald Staiger ◽  
Fausto Machicao ◽  
Alena Stančáková ◽  
Johanna Kuusisto ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variation ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Common Genetic Variation ◽  
Β Cell ◽  
Cell Dysfunction

scholarly journals Genetic Variation in Adiponectin Receptor 1 and Adiponectin Receptor 2 Is Associated With Type 2 Diabetes in the Old Order Amish

Diabetes ◽  
2005 ◽  
Vol 54 (7) ◽  
pp. 2245-2250 ◽  
Author(s):  
C. M. Damcott ◽  
S. H. Ott ◽  
T. I. Pollin ◽  
L. J. Reinhart ◽  
J. Wang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variation ◽  
Adiponectin Receptor ◽  
Old Order Amish ◽  
Adiponectin Receptor 1 ◽  
Old Order ◽  
Adiponectin Receptor 2

scholarly journals Genetic variation in TCF7L2 rs7903146 correlating with peripheral arterial disease in long-standing type 2 diabetes

2019 ◽  
Vol 17 (1) ◽  
pp. 147916411988847 ◽  
Author(s):  
Eu Jeong Ku ◽  
Gun Woo Won ◽  
Yong Hee Lee ◽  
Dong-Hwa Lee ◽  
Hyun Jeong Jeon ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variation ◽  
Confidence Interval ◽  
Peripheral Arterial Disease ◽  
Odds Ratio ◽  
Arterial Disease ◽  
Multivariate Logistic Regression Model ◽  
Peripheral Arterial ◽  
Tcf7l2 Rs7903146

Aim: The aim of this study was to investigate the association between the transcription factor 7-like 2 gene ( TCF7L2) rs7903146 polymorphism and peripheral arterial disease in type 2 diabetes. Methods: In total, 1818 Korean type 2 diabetes patients were enrolled from January 2013 to December 2017. Subjects were categorized into two groups according to their duration of type 2 diabetes: long (⩾10 years, n = 771) and short (<10 years, n = 1047) durations. A multivariate logistic regression model was used for assuming an additive effect on peripheral arterial disease for the presence of a variant allele in TCF7L2 rs7903146. Results: The frequency of the minor T-allele was 7.6% ( n = 139), and this allele was significantly associated with a 2.6-fold higher risk of peripheral arterial disease (odds ratio = 2.595, 95% confidence interval = 1.177–5.722, p = 0.018) in patients exhibiting a long duration of type 2 diabetes (⩾10 years). This result was significant after adjusting for age, sex, body mass index, familial history of diabetes, smoking, duration of diabetes and laboratory measurements, which included glycated haemoglobin, fasting plasma glucose and lipid profiles. In patients with diabetes < 10 years, there was no significant association between TCF7L2 rs7903146 and peripheral arterial disease (odds ratio = 1.233, 95% confidence interval = 0.492–3.093, p = 0.655). Conclusion: Our results provide evidence that genetic variation in TCF7L2 rs7903146 could increase risk for peripheral arterial disease in patients exhibiting long-standing type 2 diabetes.

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