scholarly journals Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians

Diabetes ◽  
2009 ◽  
Vol 58 (11) ◽  
pp. 2703-2708 ◽  
Author(s):  
J. C. Chambers ◽  
W. Zhang ◽  
D. Zabaneh ◽  
J. Sehmi ◽  
P. Jain ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variation ◽  
Plasma Glucose ◽  
Common Genetic Variation ◽  
Melatonin Receptor ◽  
Increased Risk

scholarly journals Neuregulin-4 is associated with plasma glucose and increased risk of type 2 diabetes mellitus

2019 ◽  
Author(s):  
Mehmet Z. Kocak ◽  
Gulali Aktas ◽  
Edip Erkus ◽  
Ozgur M. Yis ◽  
Tuba T. Duman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Plasma Glucose ◽  
Increased Risk ◽  
Neuregulin 4

Genetic variation within the ANGPTL4 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus

Metabolism ◽  
2008 ◽  
Vol 57 (5) ◽  
pp. 637-643 ◽  
Author(s):  
Harald Staiger ◽  
Fausto Machicao ◽  
Roman Werner ◽  
Alke Guirguis ◽  
Melanie Weisser ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Genetic Variation ◽  
Metabolic Traits ◽  
Increased Risk

scholarly journals Association of serum creatinine levels and risk of type 2 diabetes mellitus in Korea: a case control study

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Do Kyeong Song ◽  
Young Sun Hong ◽  
Yeon-Ah Sung ◽  
Hyejin Lee
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Type 2 Diabetes Mellitus ◽  
Serum Creatinine ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Increased Risk

Abstract Background Reduced skeletal muscle has been suggested as a potential risk factor for type 2 diabetes mellitus (T2DM). Serum creatinine is the primary metabolite of creatine in skeletal muscle. Therefore, low serum creatinine levels may be associated with an increased risk of T2DM. We aimed to evaluate the association between serum creatinine levels and the risk of T2DM in Korea. Methods We analyzed a total of 264,832 nondiabetic adults older than 40 years of age who had undergone a national health examination at least once from 2009 to 2015 in the Korean National Health Insurance Service Cohort. Hazard ratios for T2DM were calculated. Results In men, serum creatinine levels and the risk for T2DM showed an inverse J-shaped association. This association was confirmed after adjustment for age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), and fasting plasma glucose. In women, there was a trend that serum creatinine levels were inversely associated with the risk of T2DM among those with serum creatinine below 1.1 mg/dl. However, serum creatinine levels were not significantly associated with the risk of T2DM after adjustment for age, BMI, SBP, DBP, and fasting plasma glucose. Conclusions Reduced levels of serum creatinine were significantly associated with an increased risk of T2DM in men with creatinine below 1.20 mg/dl. There was a trend that decreased levels of serum creatinine were associated with an increased risk of T2DM among women with serum creatinine below 1.1 mg/dl, although this result was not statistically significant.

Genetic variation within the NR1H2 gene encoding liver X receptor β associates with insulin secretion in subjects at increased risk for type 2 diabetes

2010 ◽  
Vol 89 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Caroline Ketterer ◽  
Karsten Müssig ◽  
Fausto Machicao ◽  
Norbert Stefan ◽  
Andreas Fritsche ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variation ◽  
Insulin Secretion ◽  
Liver X Receptor ◽  
Gene Encoding ◽  
Increased Risk

scholarly journals Contribution of Common Genetic Variation to the Risk of Type 2 Diabetes in the Mexican Mestizo Population

Diabetes ◽  
2012 ◽  
Vol 61 (12) ◽  
pp. 3314-3321 ◽  
Author(s):  
M. A. Gamboa-Melendez ◽  
A. Huerta-Chagoya ◽  
H. Moreno-Macias ◽  
P. Vazquez-Cardenas ◽  
M. L. Ordonez-Sanchez ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variation ◽  
Common Genetic Variation ◽  
Mexican Mestizo ◽  
Mexican Mestizo Population
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