scholarly journals Taking Aim at Islet Hormones With GLP-1: Is Insulin or Glucagon the Better Target?

Diabetes ◽  
2010 ◽  
Vol 59 (7) ◽  
pp. 1572-1574 ◽  
Author(s):  
D. A. D'Alessio
Keyword(s):  
Islet Hormones

Distribution of Islet Hormones in Human Adult Pancreatic Ducts

Digestion ◽  
2015 ◽  
Vol 91 (2) ◽  
pp. 174-179 ◽  
Author(s):  
Rong Li ◽  
Lan Yu ◽  
Xiaoxi Zhang ◽  
Xia Zhou ◽  
Min Wang ◽  
...  
Keyword(s):  
Pancreatic Ducts ◽  
Human Adult ◽  
Islet Hormones

Influence of Pancreatic Duct Occlusion on Islet Hormones in Peripheral and Portal Plasma and in the Pancreas of the Mini-Pig

1985 ◽  
Vol 17 (1) ◽  
pp. 17-24 ◽  
Author(s):  
P.O. Schwille ◽  
W. Engelhardt ◽  
H. Volkholz ◽  
C. Gebhardt ◽  
H. ZimgïbV ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Pancreatic Duct Occlusion ◽  
Islet Hormones ◽  
Duct Occlusion ◽  
Portal Plasma

Biosynthesis of pancreatic islet hormones

Hepatology ◽  
1987 ◽  
Vol 7 (S1) ◽  
pp. 36S-41S ◽  
Author(s):  
Richard H. Goodman ◽  
Andrew Leiter ◽  
Malcolm J. Low ◽  
Marc R. Montminy ◽  
Toshihiko Tsukada ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Islet Hormones

Incretin and islet hormonal responses to fat and protein ingestion in healthy men

2008 ◽  
Vol 295 (4) ◽  
pp. E779-E784 ◽  
Author(s):  
Richard D. Carr ◽  
Marianne O. Larsen ◽  
Maria Sörhede Winzell ◽  
Katarina Jelic ◽  
Ola Lindgren ◽  
...  
Keyword(s):  
Hormone Secretion ◽  
Plain Water ◽  
Islet Function ◽  
Carbohydrate Ingestion ◽  
Healthy Men ◽  
Dipeptidyl Peptidase 4 ◽  
Water Ingestion ◽  
Islet Hormones ◽  
Protein Ingestion ◽  
Islet Hormone

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) regulate islet function after carbohydrate ingestion. Whether incretin hormones are of importance for islet function after ingestion of noncarbohydrate macronutrients is not known. This study therefore examined integrated incretin and islet hormone responses to ingestion of pure fat (oleic acid; 0.88 g/kg) or protein (milk and egg protein; 2 g/kg) over 5 h in healthy men, aged 20–25 yr ( n = 12); plain water ingestion served as control. Both intact (active) and total GLP-1 and GIP levels were determined as was plasma activity of dipeptidyl peptidase-4 (DPP-4). Following water ingestion, glucose, insulin, glucagon, GLP-1, and GIP levels and DPP-4 activity were stable during the 5-h study period. Both fat and protein ingestion increased insulin, glucagon, GIP, and GLP-1 levels without affecting glucose levels or DPP-4 activity. The GLP-1 responses were similar after protein and fat, whereas the early (30 min) GIP response was higher after protein than after fat ingestion ( P < 0.001). This was associated with sevenfold higher insulin and glucagon responses compared with fat ingestion (both P < 0.001). After protein, the early GIP, but not GLP-1, responses correlated to insulin ( r2= 0.86; P = 0.0001) but not glucagon responses. In contrast, after fat ingestion, GLP-1 and GIP did not correlate to islet hormones. We conclude that, whereas protein and fat release both incretin and islet hormones, the early GIP secretion after protein ingestion may be of primary importance to islet hormone secretion.

scholarly journals Interaction of Islet Hormones with Cholecystokinin Octapeptide-Evoked Secretory Responses in the Isolated Pancreas of Normal and Diabetic Rats

1999 ◽  
Vol 84 (2) ◽  
pp. 299-318 ◽  
Author(s):  
Jaipaul Singh ◽  
Ernest Adeghate ◽  
Gines M. Salido ◽  
Jose A. Pariente ◽  
Maria D. Yago ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Cholecystokinin Octapeptide ◽  
Islet Hormones ◽  
Isolated Pancreas
Sign in / Sign up

Export Citation Format

Share Document