scholarly journals Low-Affinity Major Histocompatibility Complex-Binding Peptides in Type 1 Diabetes

Diabetes ◽  
2008 ◽  
Vol 57 (7) ◽  
pp. 1788-1789 ◽  
Author(s):  
E. A. James ◽  
W. W. Kwok
Keyword(s):  
Type 1 Diabetes ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility ◽  
Major Histocompatibility Complex Binding ◽  
Histocompatibility Complex ◽  
Binding Peptides

scholarly journals The Use of Peptide-Major-Histocompatibility-Complex Multimers in Type 1 Diabetes Mellitus

2012 ◽  
Vol 6 (3) ◽  
pp. 515-524 ◽  
Author(s):  
Greg S. Gojanovich ◽  
Sabrina L. Murray ◽  
Adam S. Buntzman ◽  
Ellen F. Young ◽  
Benjamin G. Vincent ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Major Histocompatibility Complex ◽  
Type 1 Diabetes Mellitus ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

scholarly journals Making the Most of Major Histocompatibility Complex Molecule Multimers: Applications in Type 1 Diabetes

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Greg S. Gojanovich ◽  
Paul R. Hess
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Major Histocompatibility Complex ◽  
T Cell ◽  
T Lymphocytes ◽  
T Cell Subsets ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Pancreatic Islets Of Langerhans

Classical major histocompatibility complex (MHC) class I and II molecules present peptides to cognate T-cell receptors on the surface of T lymphocytes. The specificity with which T cells recognize peptide-MHC (pMHC) complexes has allowed for the utilization of recombinant, multimeric pMHC ligands for the study of minute antigen-specific T-cell populations. In type 1 diabetes (T1D), CD8+ cytotoxic T lymphocytes, in conjunction with CD4+ T helper cells, destroy the insulin-producingβcells within the pancreatic islets of Langerhans. Due to the importance of T cells in the progression of T1D, the ability to monitor and therapeutically target diabetogenic clonotypes of T cells provides a critical tool that could result in the amelioration of the disease. By administering pMHC multimers coupled to fluorophores, nanoparticles, or toxic moieties, researchers have demonstrated the ability to enumerate, track, and delete diabetogenic T-cell clonotypes that are, at least in part, responsible for insulitis; some studies even delay or prevent diabetes onset in the murine model of T1D. This paper will provide a brief overview of pMHC multimer usage in defining the role T-cell subsets play in T1D etiology and the therapeutic potential of pMHC for antigen-specific identification and modulation of diabetogenic T cells.

scholarly journals Association of Major Histocompatibility Complex Class 1 Chain-Related Gene A Dimorphism with Type 1 Diabetes and Latent Autoimmune Diabetes in Adults in the Algerian Population

2012 ◽  
Vol 19 (4) ◽  
pp. 557-561 ◽  
Author(s):  
Rachida Raache ◽  
Khadidja Belanteur ◽  
Habiba Amroun ◽  
Amel Benyahia ◽  
Amel Heniche ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Autoimmune Diabetes ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Related Gene ◽  
Latent Autoimmune Diabetes ◽  
Histocompatibility Complex

ABSTRACTMajor histocompatibility complex class I chain-related gene A (MICA-129) dimorphism was investigated in 73 autoimmune diabetes patients (type 1 diabetes and latent autoimmune diabetes in adults) and 75 controls from Algeria. Only MICA-129 Val allele and MICA-129 Val/Val genotype frequencies were higher among patients than in the control group. Statistical analysis of the estimated extended HLA-DR-DQ-MICA haplotypes shown that individual effects of MICA alleles on HLA-DQ2-DR3-MICA-129 Val/Val and HLA-DQ8-DR4-MICA-129 Val/Val haplotypes were significantly higher in patients than in the control groups. These preliminary data might suggest a relevant role of MICA-129 Val/Val single nucleotide polymorphism (weak/weak binders of NKG2D receptor) in the pathogenesis of T1D and LADA.

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